9I6W
 
 | | 14-3-3sigma binding to the ERa peptide and compound 41 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[4-[3-[(2,6-dimethylphenyl)amino]-6-methyl-imidazo[1,2-a]pyridin-2-yl]-3-fluoranyl-phenyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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9I71
 | | 14-3-3sigma binding to the ERa peptide and compound 19 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[4-[3-[(2-methoxy-6-methyl-phenyl)amino]imidazo[1,2-a]pyridin-2-yl]phenyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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9I6V
 | | 14-3-3sigma binding to the ERa peptide and compound 40 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[4-[3-[(2,6-dimethylphenyl)amino]imidazo[1,2-a]pyridin-2-yl]-3-fluoranyl-phenyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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9I70
 | | 14-3-3sigma binding to the ERa peptide and compound 17 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[4-[3-[(2,6-dimethylphenyl)amino]imidazo[1,2-a]pyridin-2-yl]phenyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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9I73
 | | 14-3-3sigma binding to the ERa peptide and compound 20 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[4-[3-[(2-fluoranyl-6-methyl-phenyl)amino]imidazo[1,2-a]pyridin-2-yl]phenyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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9I6U
 | | 14-3-3sigma binding to the ERa peptide and compound 33 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[4-[3-[(2-chloranyl-6-methyl-phenyl)amino]imidazo[1,2-a]pyridin-2-yl]cyclohexyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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9I6Z
 | | 14-3-3sigma binding to the ERa peptide and compound 2 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[4-[3-[(2-fluorophenyl)methylamino]imidazo[1,2-a]pyridin-2-yl]phenyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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9I6S
 | | 14-3-3sigma binding to the ERa peptide and compound 28 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[4-[3-[(2-chloranyl-6-methyl-phenyl)amino]-6-methyl-imidazo[1,2-a]pyridin-2-yl]phenyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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9I74
 | | 14-3-3sigma binding to the ERa peptide and compound 21 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[4-[3-[(2-chloranyl-6-methyl-phenyl)amino]imidazo[1,2-a]pyridin-2-yl]phenyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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9I6X
 | | 14-3-3sigma binding to the ERa peptide and compound 42 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[4-[6-chloranyl-3-[(2,6-dimethylphenyl)amino]imidazo[1,2-a]pyridin-2-yl]-3-fluoranyl-phenyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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9I72
 | | 14-3-3sigma binding to the ERa peptide and compound 10 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[4-(3-phenylazanylimidazo[1,2-a]pyridin-2-yl)phenyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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9I6Y
 | | 14-3-3sigma binding to the ERa peptide and compound 1 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[4-[3-[(phenylmethyl)amino]imidazo[1,2-a]pyridin-2-yl]phenyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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9I75
 | | 14-3-3sigma binding to the ERa peptide and compound 25 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[4-[3-[(2,6-dimethyl-4-oxidanyl-phenyl)amino]imidazo[1,2-a]pyridin-2-yl]phenyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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9I6T
 | | 14-3-3sigma binding to the ERa peptide and compound 32 | | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[[4-[3-[(2-chloranyl-6-methyl-phenyl)amino]imidazo[1,2-a]pyridin-2-yl]phenyl]methyl]ethanamide, CALCIUM ION, ... | | Authors: | Pennings, M.A.M, Arkin, M.R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Scaffold-hopping for molecular glues targeting the 14-3-3/ER alpha complex.
Nat Commun, 16, 2025
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