4YD2
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![BU of 4yd2 by Molmil](/molmil-images/mine/4yd2) | Nicked complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate | Descriptor: | CHLORIDE ION, DNA (5'-D(*CP*GP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*CP*GP*TP*AP*T)-3'), ... | Authors: | Moon, A.F, Gosavi, R.A, Kunkel, T.A, Pedersen, L.C, Bebenek, K. | Deposit date: | 2015-02-20 | Release date: | 2015-08-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.471 Å) | Cite: | Creative template-dependent synthesis by human polymerase mu. Proc.Natl.Acad.Sci.USA, 112, 2015
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4YCX
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![BU of 4ycx by Molmil](/molmil-images/mine/4ycx) | Binary complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate | Descriptor: | DNA (5'-D(*CP*GP*GP*CP*AP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), DNA (5'-D(P*GP*CP*CP*G)-3'), ... | Authors: | Moon, A.F, Gosavi, R.A, Kunkel, T.A, Pedersen, L.C, Bebenek, K. | Deposit date: | 2015-02-20 | Release date: | 2015-08-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Creative template-dependent synthesis by human polymerase mu. Proc.Natl.Acad.Sci.USA, 112, 2015
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7NVV
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![BU of 7nvv by Molmil](/molmil-images/mine/7nvv) | XPB-containing part of TFIIH in a post-translocated state (with ADP-BeF3) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, General transcription and DNA repair factor IIH helicase subunit XPB, ... | Authors: | Aibara, S, Schilbach, S, Cramer, P. | Deposit date: | 2021-03-16 | Release date: | 2021-05-05 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structures of mammalian RNA polymerase II pre-initiation complexes. Nature, 594, 2021
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4KBJ
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![BU of 4kbj by Molmil](/molmil-images/mine/4kbj) | |
8GZR
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![BU of 8gzr by Molmil](/molmil-images/mine/8gzr) | Cryo-EM structure of the the NS5-NS3 RNA-elongation complex | Descriptor: | CYTIDINE-5'-DIPHOSPHATE, Genome polyprotein, MANGANESE (II) ION, ... | Authors: | Osawa, T, Ehara, H, Sekine, S. | Deposit date: | 2022-09-27 | Release date: | 2023-08-02 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structures of dengue virus RNA replicase complexes. Mol.Cell, 83, 2023
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6L4R
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![BU of 6l4r by Molmil](/molmil-images/mine/6l4r) | Crystal structure of Enterovirus D68 RdRp | Descriptor: | RdRp | Authors: | Wang, M.L, Li, L, Zhang, Y, Chen, Y.P, Su, D. | Deposit date: | 2019-10-21 | Release date: | 2020-06-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.147 Å) | Cite: | Structure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel. J.Struct.Biol., 211, 2020
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3H59
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![BU of 3h59 by Molmil](/molmil-images/mine/3h59) | Hepatitis C virus polymerase NS5B with thiazine inhibitor 2 | Descriptor: | N-{3-[(5S)-5-(1,1-dimethylpropyl)-1-(4-fluoro-3-methylbenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase | Authors: | Harris, S.F, Ghate, M. | Deposit date: | 2009-04-21 | Release date: | 2009-09-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids Bioorg.Med.Chem.Lett., 19, 2009
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7ELH
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![BU of 7elh by Molmil](/molmil-images/mine/7elh) | |
3CO9
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![BU of 3co9 by Molmil](/molmil-images/mine/3co9) | Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor | Descriptor: | N-{3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyrrolo[1,2-b]pyridazin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7 -yl}methanesulfonamide, RNA-directed RNA polymerase | Authors: | Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. | Deposit date: | 2008-03-27 | Release date: | 2009-02-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 18, 2008
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6WIC
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![BU of 6wic by Molmil](/molmil-images/mine/6wic) | Pre-catalytic quaternary complex of human Polymerase Mu on a complementary DNA double-strand break substrate | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Kaminski, A.M, Kunkel, T.A, Pedersen, L.C, Bebenek, K. | Deposit date: | 2020-04-09 | Release date: | 2020-10-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural snapshots of human DNA polymerase mu engaged on a DNA double-strand break. Nat Commun, 11, 2020
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6WID
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![BU of 6wid by Molmil](/molmil-images/mine/6wid) | Nucleotide incorporation intermediate into quaternary complex of human Polymerase Mu on a complementary DNA double-strand break substrate | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Kaminski, A.M, Kunkel, T.A, Pedersen, L.C, Bebenek, K. | Deposit date: | 2020-04-09 | Release date: | 2020-10-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural snapshots of human DNA polymerase mu engaged on a DNA double-strand break. Nat Commun, 11, 2020
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4IZ0
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![BU of 4iz0 by Molmil](/molmil-images/mine/4iz0) | Crystal structure of HCV NS5B polymerase in complex with 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide | Descriptor: | 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide, RNA-directed RNA polymerase | Authors: | Coulombe, R. | Deposit date: | 2013-01-29 | Release date: | 2013-04-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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7X6S
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![BU of 7x6s by Molmil](/molmil-images/mine/7x6s) | |
3CVK
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![BU of 3cvk by Molmil](/molmil-images/mine/3cvk) | Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor | Descriptor: | N-{3-[1-(3,3-Dimethyl-butyl)-4-hydroxy-2-oxo-1,2,4a,5,6,7-hexahydro-pyrrolo[1,2-b]pyridazin-3-yl]-1,1-dioxo-1,2-dihydro -1lambda6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide, RNA-directed RNA polymerase | Authors: | Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. | Deposit date: | 2008-04-18 | Release date: | 2009-04-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 18, 2008
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7DXX
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![BU of 7dxx by Molmil](/molmil-images/mine/7dxx) | |
7DXZ
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![BU of 7dxz by Molmil](/molmil-images/mine/7dxz) | |
7DWW
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![BU of 7dww by Molmil](/molmil-images/mine/7dww) | Crystal structure of the computationally designed msDPBB_sym2 protein | Descriptor: | msDPBB_sym2 protein | Authors: | Yagi, S, Schiex, T, Vucinic, J, Barbe, S, Simoncini, D, Tagami, S. | Deposit date: | 2021-01-18 | Release date: | 2021-09-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
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7DXW
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![BU of 7dxw by Molmil](/molmil-images/mine/7dxw) | |
7DXR
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![BU of 7dxr by Molmil](/molmil-images/mine/7dxr) | Crystal structure of the mk2h peptide homodimer. | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, SULFATE ION, mk2h protein | Authors: | Yagi, S, Tagami, S. | Deposit date: | 2021-01-20 | Release date: | 2021-09-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
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7DXT
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![BU of 7dxt by Molmil](/molmil-images/mine/7dxt) | |
7DYC
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![BU of 7dyc by Molmil](/molmil-images/mine/7dyc) | |
7DXV
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![BU of 7dxv by Molmil](/molmil-images/mine/7dxv) | |
7DXU
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![BU of 7dxu by Molmil](/molmil-images/mine/7dxu) | |
7DXY
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![BU of 7dxy by Molmil](/molmil-images/mine/7dxy) | |
6YJ6
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![BU of 6yj6 by Molmil](/molmil-images/mine/6yj6) | Structure of the TFIIIC subcomplex tauA | Descriptor: | Transcription factor tau 131 kDa subunit, Transcription factor tau 55 kDa subunit, Transcription factor tau 95 kDa subunit,Transcription factor tau 95 kDa subunit | Authors: | Vorlaender, M.K, Muller, C.W. | Deposit date: | 2020-04-02 | Release date: | 2020-09-16 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of the TFIIIC subcomplex tau A provides insights into RNA polymerase III pre-initiation complex formation. Nat Commun, 11, 2020
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