2OFU
 
 | | x-ray crystal structure of 2-aminopyrimidine carbamate 43 bound to Lck | | Descriptor: | 2,6-DIMETHYLPHENYL 2-(3,5-DIMETHOXY-4-(3-(4-METHYLPIPERAZIN-1-YL)PROPOXY)PHENYLAMINO)PYRIMIDIN- 4-YL(2,4-DIMETHOXYPHENYL)CARBAMATE, Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION | | Authors: | Huang, X. | | Deposit date: | 2007-01-04 | | Release date: | 2007-02-27 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity
J.Med.Chem., 49, 2006
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8T3B
 | | Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure I | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Zhao, Y, Li, H. | | Deposit date: | 2023-06-07 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (3.08 Å) | | Cite: | Regulation of Translation by Ribosome RNA 2'-O-Methylation
To be Published
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3RDA
 | | Human Cyclophilin D Complexed with a Fragment | | Descriptor: | 3-methyl-1,2-oxazol-5-amine, Peptidyl-prolyl cis-trans isomerase F, mitochondrial | | Authors: | Colliandre, L, Ahmed-Belkacem, H, Bessin, Y, Pawlotsky, J.M, Guichou, J.F. | | Deposit date: | 2011-04-01 | | Release date: | 2012-03-21 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.07 Å) | | Cite: | Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Nat Commun, 7, 2016
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8T30
 | | Hypomethylated yeast 80S bound with cycloheximide, unmodified U2921, mid rotated | | Descriptor: | 18S rRNA, 25S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | | Authors: | Zhao, Y, Li, H. | | Deposit date: | 2023-06-07 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Regulation of Translation by Ribosome RNA 2'-O-Methylation
To be published
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3ZY6
 | | Crystal structure of POFUT1 in complex with GDP-fucose (crystal-form-II) | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE-BETA-L-FUCOPYRANOSE, PUTATIVE GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1 | | Authors: | Lira-Navarrete, E, Valero-Gonzalez, J, Villanueva, R, Martinez-Julvez, M, Tejero, T, Merino, P, Panjikar, S, Hurtado-Guerrero, R. | | Deposit date: | 2011-08-17 | | Release date: | 2011-09-14 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Structural Insights Into the Mechanism of Protein O-Fucosylation.
Plos One, 6, 2011
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3R1X
 | | Crystal structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae | | Descriptor: | 2-oxo-3-deoxygalactonate kinase, FORMIC ACID, GLYCEROL | | Authors: | Michalska, K, Cuff, M.E, Tesar, C, Feldmann, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2011-03-11 | | Release date: | 2011-04-13 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.093 Å) | | Cite: | Structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae.
Acta Crystallogr.,Sect.D, 67, 2011
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9C5V
 | | Cryo EM structure of a DCAF2:degrader:BRD4 ternary complex | | Descriptor: | Bromodomain-containing protein 4, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, ... | | Authors: | McMahon, E.J, Wang, W. | | Deposit date: | 2024-06-06 | | Release date: | 2025-10-01 | | Last modified: | 2025-10-15 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | Structural basis for DCAF2 as a novel E3 ligase for PROTAC-mediated targeted protein degradation.
Structure, 2025
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5EIR
 | | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | | Descriptor: | Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E, SULFATE ION, ... | | Authors: | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | | Deposit date: | 2015-10-30 | | Release date: | 2016-09-07 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.
Eur.J.Med.Chem., 124, 2016
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3F2O
 | | Crystal Structure of human splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1) in complex with a 20-residue VASA peptide | | Descriptor: | 20-mer peptide from ATP-dependent RNA helicase vasa, SPRY domain-containing SOCS box protein 1 | | Authors: | Filippakopoulos, P, Sharpe, T, Keates, T, Murray, J.W, Savitsky, P, Roos, A, Pike, A.C.W, Von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Bullock, A, Structural Genomics Consortium (SGC) | | Deposit date: | 2008-10-30 | | Release date: | 2008-12-09 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
J.Mol.Biol., 401, 2010
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5VC6
 | | crystal structure of human WEE1 kinase domain in complex with PHA-848125 | | Descriptor: | 1,2-ETHANEDIOL, N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE, Wee1-like protein kinase | | Authors: | Zhu, J.-Y, Schonbrunn, E. | | Deposit date: | 2017-03-31 | | Release date: | 2017-08-23 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.
J. Med. Chem., 60, 2017
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8T3E
 | | Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure IV | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Zhao, Y, Li, H. | | Deposit date: | 2023-06-07 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Structures of Hypopseudouridylated Ribosome in IRES-mediated Translation Initiation
To be Published
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7FPK
 | | PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P10E03 from the F2X-Universal Library | | Descriptor: | 1-[2-(pyrrolidin-1-yl)pyridin-3-yl]methanamine, A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 | | Authors: | Barthel, T, Wollenhaupt, J, Lima, G.M.A, Wahl, M.C, Weiss, M.S. | | Deposit date: | 2022-08-26 | | Release date: | 2022-11-02 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites.
J.Med.Chem., 65, 2022
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5OS4
 | | Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment | | Descriptor: | (3~{a}~{R},5~{S},7~{a}~{S})-5-phenyl-3~{a},4,5,6,7,7~{a}-hexahydroisoindole-1,3-dione, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ... | | Authors: | McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R. | | Deposit date: | 2017-08-16 | | Release date: | 2017-11-01 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
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3FMK
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2VR5
 | | Crystal structure of Trex from Sulfolobus Solfataricus in complex with acarbose intermediate and glucose | | Descriptor: | 4-O-(4,6-dideoxy-4-{[(1S,2S,3S,4R,5S)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl]amino}-alpha-D-glucopyranosyl)-beta-D-glucopyranose, GLYCEROL, GLYCOGEN OPERON PROTEIN GLGX, ... | | Authors: | Song, H.-N, Yoon, S.-M, Lee, S.-J, Cha, H.-J, Park, K.-H, Woo, E.-J. | | Deposit date: | 2008-03-26 | | Release date: | 2008-07-29 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Insight Into the Bifunctional Mechanism of the Glycogen-Debranching Enzyme Trex from the Archaeon Sulfolobus Solfataricus.
J.Biol.Chem., 283, 2008
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9YV4
 | | Crystal structure of the human DCAF1 WDR domain in complex with OICR-41109 | | Descriptor: | (4P)-4-(4-chloro-2-fluorophenyl)-N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-cyanoethyl]-5-[(1E)-3-oxo-3-(pyrrolidin-1-yl)prop-1-en-1-yl]-1H-pyrrole-3-carboxamide, DDB1- and CUL4-associated factor 1, SODIUM ION, ... | | Authors: | Kimani, S, Dong, A, Li, Y, Seitova, A, Mamai, A, Al-awar, R, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2025-10-23 | | Release date: | 2025-11-26 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | OICR-41103 as a chemical probe for the DCAF1 WD40 domain
Commun Biol, 8, 2025
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2VUR
 | | Chemical dissection of the link between Streptozotocin, O-GlcNAc and pancreatic cell death | | Descriptor: | 2-deoxy-2-{[(2-hydroxy-1-methylhydrazino)carbonyl]amino}-beta-D-glucopyranose, O-GLCNACASE NAGJ, SULFATE ION | | Authors: | Pathak, S, Dorfmueller, H.C, Borodkin, V.S, van Aalten, D.M.F. | | Deposit date: | 2008-05-29 | | Release date: | 2009-02-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Chemical Dissection of the Link between Streptozotocin, O-Glcnac, and Pancreatic Cell Death.
Chem.Biol., 15, 2008
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3DZV
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8T2X
 | | Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, A-site tRNA, messenger RNA and eIF5A, PRE | | Descriptor: | 18S rRNA, 25S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | | Authors: | Zhao, Y, Li, H. | | Deposit date: | 2023-06-07 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (2.46 Å) | | Cite: | Regulation of Translation by Ribosome RNA 2'-Hydroxyl Methylation
To be published
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8T3F
 | | Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure V | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Zhao, Y, Li, H. | | Deposit date: | 2023-06-07 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Regulation of Translation by Ribosome RNA 2'-O-Methylation
To be Published
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3REW
 | | Crystal structure of an lmp2a-derived peptide bound to human class i mhc hla-a2 | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, CHLORIDE ION, ... | | Authors: | Wood, A, Mohammed, F, Salim, M, Tranter, A, Rickinson, A.B, Moss, P.A.H, Stauss, H.J, Steven, N.M, Willcox, B.E. | | Deposit date: | 2011-04-05 | | Release date: | 2012-01-18 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and energetic evidence for highly peptide-specific tumor antigen targeting via allo-MHC restriction.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3YPI
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8T2Y
 | | Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, PRE | | Descriptor: | 18S rRNA, 25S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | | Authors: | Zhao, Y, Li, H. | | Deposit date: | 2023-06-07 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Regulation of Translation by Ribosome RNA 2'-O-Methylation
To Be Published
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8T3A
 | | Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, sordarin, and hibernating factor Los2 | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Zhao, Y, Li, H. | | Deposit date: | 2023-06-07 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Regulation of Translation by Ribosome RNA 2'-O-Methylation
To be Published
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8T2Z
 | | Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, POST | | Descriptor: | 18S rRNA, 25S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | | Authors: | Zhao, Y, Li, H. | | Deposit date: | 2023-06-07 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Structures of Hypopseudouridylated Ribosome in IRES-mediated Translation
To Be Published
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