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181L	SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY Descriptor: 2-HYDROXYETHYL DISULFIDE, BENZENE, CHLORIDE ION, ... Authors: Morton, A, Matthews, B.W. Deposit date: 1995-04-19 Release date: 1995-07-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Specificity of ligand binding in a buried nonpolar cavity of T4 lysozyme: linkage of dynamics and structural plasticity. Biochemistry, 34, 1995
188L	SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, ORTHO-XYLENE, ... Authors: Morton, A, Matthews, B.W. Deposit date: 1995-04-19 Release date: 1995-07-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Specificity of ligand binding in a buried nonpolar cavity of T4 lysozyme: linkage of dynamics and structural plasticity. Biochemistry, 34, 1995
151L	CONSERVATION OF SOLVENT-BINDING SITES IN 10 CRYSTAL FORMS OF T4 LYSOZYME Descriptor: PHOSPHATE ION, T4 LYSOZYME Authors: Zhang, X.-J, Matthews, B.W. Deposit date: 1994-01-25 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Conservation of solvent-binding sites in 10 crystal forms of T4 lysozyme. Protein Sci., 3, 1994
186L	SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, N-BUTYLBENZENE, ... Authors: Morton, A, Matthews, B.W. Deposit date: 1995-04-19 Release date: 1995-07-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Specificity of ligand binding in a buried nonpolar cavity of T4 lysozyme: linkage of dynamics and structural plasticity. Biochemistry, 34, 1995
191L	A HELIX INITIATION SIGNAL IN T4 LYSOZYME IDENTIFIED BY POLYALANINE MUTAGENESIS Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Zhang, X.-J, Matthews, B.W. Deposit date: 1995-06-13 Release date: 1995-09-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A helix initiation signal in T4 lysozyme identified by polyalanine mutagenesis. Biophys.Chem., 101-102, 2002
102L	HOW AMINO-ACID INSERTIONS ARE ALLOWED IN AN ALPHA-HELIX OF T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Heinz, D.W, Matthews, B.W. Deposit date: 1992-09-29 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.74 Å) Cite: How amino-acid insertions are allowed in an alpha-helix of T4 lysozyme. Nature, 361, 1993
1JTM	Alternative Structures of a Sequence Extended T4 Lysozyme Show that the Highly Conserved Beta-Sheet has Weak Intrinsic Folding Propensity Descriptor: BETA-MERCAPTOETHANOL, LYSOZYME Authors: Sagermann, M, Matthews, B.W. Deposit date: 2001-08-21 Release date: 2002-03-20 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structures of a T4-lysozyme Duplication-extension Mutant Demonstrate that the Highly Conserved beta-Sheet Region has Low Intrinsic Folding Propensity J.Mol.Biol., 316, 2002
1KW5	METHIONINE CORE MUTANT OF T4 LYSOZYME Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Baase, W.A, Mooers, B.H, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.W. Deposit date: 2002-01-28 Release date: 2003-06-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability BIOPHYS.CHEM., 100, 2003
1L98	PERTURBATION OF TRP 138 IN T4 LYSOZYME BY MUTATIONS AT GLN 105 USED TO CORRELATE CHANGES IN STRUCTURE, STABILITY, SOLVATION, AND SPECTROSCOPIC PROPERTIES Descriptor: BETA-MERCAPTOETHANOL, T4 LYSOZYME Authors: Pjura, P, Mcintosh, L.P, Wozniak, J.A, Matthews, B.W. Deposit date: 1992-07-13 Release date: 1993-10-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Perturbation of Trp 138 in T4 lysozyme by mutations at Gln 105 used to correlate changes in structure, stability, solvation, and spectroscopic properties. Proteins, 15, 1993
1L00	PERTURBATION OF TRP 138 IN T4 LYSOZYME BY MUTATIONS AT GLN 105 USED TO CORRELATE CHANGES IN STRUCTURE, STABILITY, SOLVATION, AND SPECTROSCOPIC PROPERTIES Descriptor: BETA-MERCAPTOETHANOL, T4 LYSOZYME Authors: Pjura, P, Mcintosh, L.P, Wozniak, J.A, Matthews, B.W. Deposit date: 1992-07-13 Release date: 1993-10-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Perturbation of Trp 138 in T4 lysozyme by mutations at Gln 105 used to correlate changes in structure, stability, solvation, and spectroscopic properties. Proteins, 15, 1993
1L99	PERTURBATION OF TRP 138 IN T4 LYSOZYME BY MUTATIONS AT GLN 105 USED TO CORRELATE CHANGES IN STRUCTURE, STABILITY, SOLVATION, AND SPECTROSCOPIC PROPERTIES Descriptor: BETA-MERCAPTOETHANOL, T4 LYSOZYME Authors: Pjura, P, Mcintosh, L.P, Wozniak, J.A, Matthews, B.W. Deposit date: 1992-07-13 Release date: 1993-10-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Perturbation of Trp 138 in T4 lysozyme by mutations at Gln 105 used to correlate changes in structure, stability, solvation, and spectroscopic properties. Proteins, 15, 1993
1LYE	DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59 Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Bell, J.A, Becktel, W.J, Sauer, U, Baase, W.A, Matthews, B.W. Deposit date: 1992-08-10 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59. Biochemistry, 31, 1992
1L06	CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Dao-Pin, S, Wilson, K, Alber, T, Matthews, B.W. Deposit date: 1988-02-05 Release date: 1988-04-16 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme. Nature, 330, 1987
1L10	STRUCTURAL STUDIES OF MUTANTS OF THE LYSOZYME OF BACTERIOPHAGE T4. THE TEMPERATURE-SENSITIVE MUTANT PROTEIN THR157 (RIGHT ARROW) ILE Descriptor: T4 LYSOZYME Authors: Dao-Pin, S, Wilson, K, Alber, T, Matthews, B.W. Deposit date: 1988-02-05 Release date: 1988-04-16 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural studies of mutants of the lysozyme of bacteriophage T4. The temperature-sensitive mutant protein Thr157----Ile. J.Mol.Biol., 197, 1987
1L15	CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Dao-Pin, S, Alber, T, Matthews, B.W. Deposit date: 1988-02-05 Release date: 1988-04-16 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme. Nature, 330, 1987
1L21	CONTRIBUTIONS OF LEFT-HANDED HELICAL RESIDUES TO THE STRUCTURE AND STABILITY OF BACTERIOPHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Nicholson, H, Matthews, B.W. Deposit date: 1989-05-01 Release date: 1990-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Contributions of left-handed helical residues to the structure and stability of bacteriophage T4 lysozyme. J.Mol.Biol., 210, 1989
1L28	REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY Descriptor: T4 LYSOZYME Authors: Bell, J.A, Dao-Pin, S, Matthews, B.W. Deposit date: 1989-05-01 Release date: 1990-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Replacements of Pro86 in phage T4 lysozyme extend an alpha-helix but do not alter protein stability. Science, 239, 1988
1L40	CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS Descriptor: T4 LYSOZYME Authors: Daopin, S, Matthews, B.W. Deposit date: 1991-01-28 Release date: 1991-10-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis. Biochemistry, 30, 1991
1L47	CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY Descriptor: T4 LYSOZYME Authors: Daopin, S, Matthews, B.W. Deposit date: 1991-01-28 Release date: 1991-10-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability. J.Mol.Biol., 221, 1991
1L50	STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Daopin, S, Matthews, B.W. Deposit date: 1991-01-28 Release date: 1991-10-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural and thermodynamic analysis of the packing of two alpha-helices in bacteriophage T4 lysozyme. J.Mol.Biol., 221, 1991
1L45	CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY Descriptor: T4 LYSOZYME Authors: Daopin, S, Matthews, B.W. Deposit date: 1991-01-28 Release date: 1991-10-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability. J.Mol.Biol., 221, 1991
1L55	ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Nicholson, H, Matthews, B.W. Deposit date: 1991-05-06 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme. Biochemistry, 30, 1991
1L69	MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Zhang, X, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992
1L85	SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Eriksson, A.E, Matthews, B.W. Deposit date: 1992-01-21 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J.Mol.Biol., 229, 1993
1LGU	T4 Lysozyme Mutant L99A/M102Q Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme Authors: Wei, B.Q, Baase, W.A, Weaver, L.H, Matthews, B.W, Shoichet, B.K. Deposit date: 2002-04-16 Release date: 2002-05-08 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A Model Binding Site for Testing Scoring Functions in Molecular Docking J.Mol.Biol., 322, 2002

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