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239L	THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT Descriptor: CHLORIDE ION, T4 LYSOZYME Authors: Xu, J, Baase, W.A, Baldwin, E, Matthews, B.W. Deposit date: 1997-10-23 Release date: 1998-03-18 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect. Protein Sci., 7, 1998
250L	THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, T4 LYSOZYME Authors: Xu, J, Baase, W.A, Baldwin, E, Matthews, B.W. Deposit date: 1997-10-22 Release date: 1998-03-18 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect. Protein Sci., 7, 1998
257L	AN ADAPTABLE METAL-BINDING SITE ENGINEERED INTO T4 LYSOZYME Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, PROTEIN (LYSOZYME) Authors: Wray, J.W, Baase, W.A, Ostheimer, G.J, Matthews, B.W. Deposit date: 1999-01-05 Release date: 2000-09-11 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Use of a non-rigid region in T4 lysozyme to design an adaptable metal-binding site. Protein Eng., 13, 2000
213L	PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Vetter, I.R, Baase, W.A, Heinz, D.W, Xiong, J.-P, Snow, S, Matthews, B.W. Deposit date: 1996-09-23 Release date: 1996-12-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme. Protein Sci., 5, 1996
211L	PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME Descriptor: 2-HYDROXYETHYL DISULFIDE, T4 LYSOZYME Authors: Vetter, I.R, Baase, W.A, Heinz, D.W, Xiong, J.-P, Snow, S, Matthews, B.W. Deposit date: 1996-09-23 Release date: 1996-12-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme. Protein Sci., 5, 1996
253L	LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Kuroki, R, Shoichet, B, Weaver, L.H, Matthews, B.W. Deposit date: 1997-11-10 Release date: 1998-01-28 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2 Å) Cite: A relationship between protein stability and protein function. Proc.Natl.Acad.Sci.USA, 92, 1995
219L	PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME Descriptor: 2-HYDROXYETHYL DISULFIDE, T4 LYSOZYME Authors: Vetter, I.R, Baase, W.A, Heinz, D.W, Xiong, J.-P, Snow, S, Matthews, B.W. Deposit date: 1996-09-23 Release date: 1996-12-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme. Protein Sci., 5, 1996
210L	PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME Descriptor: 2-HYDROXYETHYL DISULFIDE, T4 LYSOZYME Authors: Vetter, I.R, Baase, W.A, Heinz, D.W, Xiong, J.-P, Snow, S, Matthews, B.W. Deposit date: 1996-09-23 Release date: 1996-12-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme. Protein Sci., 5, 1996
214L	PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Vetter, I.R, Baase, W.A, Heinz, D.W, Xiong, J.-P, Snow, S, Matthews, B.W. Deposit date: 1996-09-23 Release date: 1996-12-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme. Protein Sci., 5, 1996
218L	PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Vetter, I.R, Baase, W.A, Heinz, D.W, Xiong, J.-P, Snow, S, Matthews, B.W. Deposit date: 1996-09-23 Release date: 1996-12-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme. Protein Sci., 5, 1996
209L	PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Vetter, I.R, Baase, W.A, Heinz, D.W, Xiong, J.-P, Snow, S, Matthews, B.W. Deposit date: 1996-09-23 Release date: 1996-12-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme. Protein Sci., 5, 1996
212L	PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME Descriptor: 2-HYDROXYETHYL DISULFIDE, T4 LYSOZYME Authors: Vetter, I.R, Baase, W.A, Heinz, D.W, Xiong, J.-P, Snow, S, Matthews, B.W. Deposit date: 1996-09-23 Release date: 1996-12-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme. Protein Sci., 5, 1996
255L	HYDROLASE Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Kuroki, R, Shoichet, B, Weaver, L.H, Matthews, B.W. Deposit date: 1997-11-10 Release date: 1998-01-28 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A relationship between protein stability and protein function. Proc.Natl.Acad.Sci.USA, 92, 1995
206L	PHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Blaber, M, Matthews, B.W. Deposit date: 1996-03-19 Release date: 1996-08-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Energetic cost and structural consequences of burying a hydroxyl group within the core of a protein determined from Ala-->Ser and Val-->Thr substitutions in T4 lysozyme. Biochemistry, 32, 1993
215L	PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME Descriptor: 2-HYDROXYETHYL DISULFIDE, T4 LYSOZYME Authors: Vetter, I.R, Baase, W.A, Heinz, D.W, Xiong, J.-P, Snow, S, Matthews, B.W. Deposit date: 1996-09-23 Release date: 1996-12-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme. Protein Sci., 5, 1996
1JTM	Alternative Structures of a Sequence Extended T4 Lysozyme Show that the Highly Conserved Beta-Sheet has Weak Intrinsic Folding Propensity Descriptor: BETA-MERCAPTOETHANOL, LYSOZYME Authors: Sagermann, M, Matthews, B.W. Deposit date: 2001-08-21 Release date: 2002-03-20 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structures of a T4-lysozyme Duplication-extension Mutant Demonstrate that the Highly Conserved beta-Sheet Region has Low Intrinsic Folding Propensity J.Mol.Biol., 316, 2002
1KNI	Stabilizing Disulfide Bridge Mutant of T4 Lysozyme Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Jacobson, R.H, Matsumura, M, Faber, H.R, Matthews, B.W. Deposit date: 2001-12-18 Release date: 2001-12-28 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure of a stabilizing disulfide bridge mutant that closes the active-site cleft of T4 lysozyme. Protein Sci., 1, 1992
1KS3	METHIONINE CORE MUTANT OF T4 LYSOZYME Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Baase, W.A, Mooers, B.H, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.W. Deposit date: 2002-01-10 Release date: 2003-06-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability BIOPHYS.CHEM., 100, 2003
1I6S	T4 LYSOZYME MUTANT C54T/C97A/N101A Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Kovall, R.A, Baldwin, E.P, Matthews, B.W. Deposit date: 2001-03-04 Release date: 2001-05-09 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and thermodynamic analysis of the binding of solvent at internal sites in T4 lysozyme. Protein Sci., 10, 2001
1L63	ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Nicholson, H, Matthews, B.W. Deposit date: 1991-05-06 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme. Biochemistry, 30, 1991
1L80	DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Hurley, J.H, Matthews, B.W. Deposit date: 1991-11-12 Release date: 1993-04-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme. J.Mol.Biol., 224, 1992
1L89	SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Eriksson, A.E, Matthews, B.W. Deposit date: 1992-01-21 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J.Mol.Biol., 229, 1993
1L30	REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY Descriptor: T4 LYSOZYME Authors: Bell, J.A, Dao-Pin, S, Matthews, B.W. Deposit date: 1989-05-01 Release date: 1990-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Replacements of Pro86 in phage T4 lysozyme extend an alpha-helix but do not alter protein stability. Science, 239, 1988
1L36	TOWARD A SIMPLIFICATION OF THE PROTEIN FOLDING PROBLEM: A STABILIZING POLYALANINE ALPHA-HELIX ENGINEERED IN T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Zhang, X.-J, Baase, W.A, Matthews, B.W. Deposit date: 1990-12-26 Release date: 1991-10-15 Last modified: 2022-11-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Toward a simplification of the protein folding problem: a stabilizing polyalanine alpha-helix engineered in T4 lysozyme. Biochemistry, 30, 1991
1L52	STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Daopin, S, Matthews, B.W. Deposit date: 1991-01-28 Release date: 1991-10-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural and thermodynamic analysis of the packing of two alpha-helices in bacteriophage T4 lysozyme. J.Mol.Biol., 221, 1991

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