8IJL
| Cyo-EM structure of wildtype non-gastric proton pump in the presence of Na+, AlF and ADP | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... | Authors: | Abe, K. | Deposit date: | 2023-02-27 | Release date: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.62 Å) | Cite: | An unusual conformation from Na + -sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na + -binding. Biochim Biophys Acta Mol Cell Res, 1870, 2023
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8IEM
| Cryo-EM structure of ATP13A2 in the E2P state | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Polyamine-transporting ATPase 13A2, ... | Authors: | Liu, Z.M, Mu, J.Q, Xue, C.Y. | Deposit date: | 2023-02-15 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Conformational cycle of human polyamine transporter ATP13A2. Nat Commun, 14, 2023
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8IEN
| Cryo-EM structure of ATP13A2 in the E2-Pi state | Descriptor: | MAGNESIUM ION, Polyamine-transporting ATPase 13A2, SPERMINE, ... | Authors: | Liu, Z.M, Mu, J.Q, Xue, C.Y. | Deposit date: | 2023-02-15 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Conformational cycle of human polyamine transporter ATP13A2. Nat Commun, 14, 2023
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8IES
| Cryo-EM structure of ATP13A2 in the E1P-ADP state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Polyamine-transporting ATPase 13A2, ... | Authors: | Liu, Z.M, Mu, J.Q, Xue, C.Y. | Deposit date: | 2023-02-15 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Conformational cycle of human polyamine transporter ATP13A2. Nat Commun, 14, 2023
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8IER
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8IEL
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8IEK
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8IEO
| Cryo-EM structure of ATP13A2 in the nominal E1P state | Descriptor: | MAGNESIUM ION, Polyamine-transporting ATPase 13A2, SPERMINE, ... | Authors: | Liu, Z.M, Mu, J.Q, Xue, C.Y. | Deposit date: | 2023-02-15 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | Conformational cycle of human polyamine transporter ATP13A2. Nat Commun, 14, 2023
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8IWT
| hSPCA1 in the early E2P state | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | Deposit date: | 2023-03-31 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
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8IWR
| hSPCA1 in the CaE1-ATP state | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION, ... | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | Deposit date: | 2023-03-31 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
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8IWP
| hSPCA1 in the CaE1 state | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1 | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | Deposit date: | 2023-03-30 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
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8IWW
| hSPCA1 in the CaE1P-ADP state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calcium-transporting ATPase type 2C member 1, ... | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | Deposit date: | 2023-03-31 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
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8IWU
| hSPCA1 in the E2~P state | Descriptor: | Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION, TETRAFLUOROALUMINATE ION | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | Deposit date: | 2023-03-31 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
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8IWS
| hSPCA1 in the CaE2P state | Descriptor: | BERYLLIUM TRIFLUORIDE ION, CALCIUM ION, Calcium-transporting ATPase type 2C member 1, ... | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | Deposit date: | 2023-03-31 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
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8JMN
| Cryo-EM structure of the gastric proton pump with bound DQ-21 | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[4-[[2-[(4-chlorophenyl)methoxy]phenyl]methoxy]phenyl]-N-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Abe, K, Yokoshima, S, Yoshimori, A. | Deposit date: | 2023-06-05 | Release date: | 2023-08-30 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.26 Å) | Cite: | Deep learning driven de novo drug design based on gastric proton pump structures. Commun Biol, 6, 2023
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7D94
| Crystal Structure of the Na+,K+-ATPase in the E2P state with bound one Mg2+ and one Rb+ in the presence of bufalin | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kanai, R, Cornelius, F, Ogawa, H, Motoyama, K, Vilsen, B, Toyoshima, C. | Deposit date: | 2020-10-12 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021
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7DDF
| Crystal structures of Na+,K+-ATPase in complex with beryllium fluoride | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ogawa, H, Cornelius, F, Kanai, R, Motoyama, K, Vilsen, B, Toyoshima, C. | Deposit date: | 2020-10-29 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (4.62 Å) | Cite: | Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021
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7D91
| Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ (P4(3)2(1)2 symmetry) | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kanai, R, Cornelius, F, Ogawa, H, Motoyama, K, Vilsen, B, Toyoshima, C. | Deposit date: | 2020-10-12 | Release date: | 2021-01-27 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021
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7DDL
| Crystal structures of Na+,K+-ATPase in complex with bufalin | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ogawa, H, Cornelius, F, Kanai, R, Motoyama, K, Vilsen, B, Toyoshima, C. | Deposit date: | 2020-10-29 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021
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7D92
| Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ and anthroylouabain (P4(3)2(1)2 symmetry) | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kanai, R, Cornelius, F, Ogawa, H, Motoyama, K, Vilsen, B, Toyoshima, C. | Deposit date: | 2020-10-12 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021
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7DDH
| Crystal structures of Na+,K+-ATPase in complex with digoxin | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ogawa, H, Cornelius, F, Kanai, R, Motoyama, K, Vilsen, B, Toyoshima, C. | Deposit date: | 2020-10-29 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.46 Å) | Cite: | Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021
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8K1L
| Cryo-EM structure of Na+,K+-ATPase alpha2 from Artemia salina in cation-free E2P form | Descriptor: | Na+,K+-ATPase alpha2KK, Na+,K+-ATPase beta2, TETRAFLUOROALUMINATE ION | Authors: | Abe, K, Artigas, P. | Deposit date: | 2023-07-11 | Release date: | 2023-11-29 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities. Proc.Natl.Acad.Sci.USA, 120, 2023
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7D93
| Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ and anthroylouabain (P2(1)2(1)2(1) symmetry) | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kanai, R, Cornelius, F, Ogawa, H, Motoyama, K, Vilsen, B, Toyoshima, C. | Deposit date: | 2020-10-12 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.65 Å) | Cite: | Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021
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7DDI
| Crystal structures of Na+,K+-ATPase in complex with digitoxin | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ogawa, H, Cornelius, F, Kanai, R, Motoyama, K, Vilsen, B, Toyoshima, C. | Deposit date: | 2020-10-29 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.72 Å) | Cite: | Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021
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7DDK
| Crystal structures of Na+,K+-ATPase in complex with rostafuroxin | Descriptor: | (3S,5R,8R,9S,10S,13S,14S,17S)-17-(furan-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ogawa, H, Cornelius, F, Kanai, R, Motoyama, K, Vilsen, B, Toyoshima, C. | Deposit date: | 2020-10-29 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021
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