PDB: 99158 resultsInfo pagesStatus searchChemie searchBIRD

---

2AN5	Structure of human PNMT complexed with S-adenosyl-homocysteine and an inhibitor, trans-(1S,2S)-2-amino-1-tetralol Descriptor: PHOSPHATE ION, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ... Authors: Gee, C.L, Tyndall, J.D.A, Grunewald, G.L, Wu, Q, McLeish, M.J, Martin, J.L. Deposit date: 2005-08-11 Release date: 2006-03-14 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis Biochemistry, 44, 2005
4IEY	Cys-persulfenate bound Cysteine Dioxygenase at pH 7.0 in the presence of Cys, home-source structure Descriptor: Cysteine dioxygenase type 1, FE (II) ION, S-HYDROPEROXYCYSTEINE Authors: Driggers, C.M, Cooley, R.B, Karplus, P.A. Deposit date: 2012-12-13 Release date: 2013-06-26 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Cysteine Dioxygenase Structures from pH4 to 9: Consistent Cys-Persulfenate Formation at Intermediate pH and a Cys-Bound Enzyme at Higher pH. J.Mol.Biol., 425, 2013
6MWK	Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) Burkholderia pseudomallei in complex with ligand HGN-0883 Descriptor: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 4-amino-N-(6-methoxypyrimidin-4-yl)benzene-1-sulfonamide, DIMETHYL SULFOXIDE, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-10-29 Release date: 2019-11-06 Last modified: 2025-04-09 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Analysis of Burkholderia pseudomallei IspF in complex with sulfapyridine, sulfamonomethoxine, ethoxzolamide and acetazolamide Acta Crystallogr.,Sect.F, 81, 2025
3QI6	Crystal Structure of Cystathionine gamma-synthase MetB (Cgs) from Mycobacterium ulcerans Agy99 Descriptor: 1,2-ETHANEDIOL, Cystathionine gamma-synthase MetB (Cgs), GLYCEROL, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-01-26 Release date: 2011-03-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Structure of the cystathionine [gamma]-synthase MetB from Mycobacterium ulcerans Acta Crystallogr.,Sect.F, 67, 2011
1KVX	CARBOXYLIC ESTER HYDROLASE, SINGLE MUTANT D99A OF BOVINE PANCREATIC PLA2, 1.9 A ORTHORHOMBIC FORM Descriptor: CALCIUM ION, PHOSPHOLIPASE A2 Authors: Sundaralingam, M. Deposit date: 1998-04-28 Release date: 1998-11-18 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structures of the catalytic site mutants D99A and H48Q and the calcium-loop mutant D49E of phospholipase A2. Acta Crystallogr.,Sect.D, 55, 1999
6MWI	Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) Burkholderia pseudomallei in complex with ligand HGN-0456 Descriptor: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 6-ethoxy-1,3-benzothiazole-2-sulfonamide, ACETATE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-10-29 Release date: 2019-11-06 Last modified: 2025-04-09 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Analysis of Burkholderia pseudomallei IspF in complex with sulfapyridine, sulfamonomethoxine, ethoxzolamide and acetazolamide Acta Crystallogr.,Sect.F, 81, 2025
3WJY	Orotidine 5'-monophosphate decarboxylase K72A mutant from M. thermoautotrophicus complexed with 6-amino-UMP Descriptor: 6-AMINOURIDINE 5'-MONOPHOSPHATE, GLYCEROL, Orotidine 5'-phosphate decarboxylase Authors: Fujihashi, M, Pai, E.F, Miki, K. Deposit date: 2013-10-17 Release date: 2013-12-04 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase. J.Am.Chem.Soc., 135, 2013
4QOC	crystal structure of compound 16 bound to MDM2(17-111), {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2-(PYRROLIDIN-1-YLSULFONYL)ETHYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID Descriptor: E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-(pyrrolidin-1-ylsulfonyl)ethyl]-3-methyl-2-oxopiperidin-3-yl}acetic acid Authors: Huang, X. Deposit date: 2014-06-19 Release date: 2015-05-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction. Bioorg.Med.Chem.Lett., 24, 2014
3OKN	Crystal structure of S25-39 in complex with Kdo(2.4)Kdo(2.4)Kdo Descriptor: 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-prop-2-en-1-yl 3-deoxy-alpha-D-manno-oct-2-ulopyranosidonic acid, S25-39 Fab (IgG1k) heavy chain, S25-39 Fab (IgG1k) light chain, ... Authors: Blackler, R.J, Evans, S.V. Deposit date: 2010-08-25 Release date: 2011-04-06 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.15 Å) Cite: A Common NH53K Mutation in the Combining Site of Antibodies Raised against Chlamydial LPS Glycoconjugates Significantly Increases Avidity. Biochemistry, 50, 2011
4RDX	Structure of histidinyl-tRNA synthetase in complex with tRNA(His) Descriptor: ADENOSINE MONOPHOSPHATE, HISTIDINE, Histidine--tRNA ligase, ... Authors: Xie, W, Tian, Q, Wang, C. Deposit date: 2014-09-20 Release date: 2015-03-25 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural basis for recognition of G-1-containing tRNA by histidyl-tRNA synthetase Nucleic Acids Res., 43, 2015
1UGN	Crystal structure of LIR1.02, one of the alleles of LIR1 Descriptor: Leukocyte immunoglobulin-like receptor 1 Authors: Shiroishi, M, Rasubala, L, Kuroki, K, Amano, K, Tsuchiya, N, Tokunaga, K, Kohda, D, Maenaka, K. Deposit date: 2003-06-17 Release date: 2004-08-10 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. Hum.Mol.Genet., 14, 2005
3TTK	Crystal structure of apo-SpuD Descriptor: Polyamine transport protein Authors: Wu, D.H, Lim, S.C, Song, H.W. Deposit date: 2011-09-14 Release date: 2012-03-28 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.97 Å) Cite: Structural Basis of Substrate Binding Specificity Revealed by the Crystal Structures of Polyamine Receptors SpuD and SpuE from Pseudomonas aeruginosa J.Mol.Biol., 416, 2012
4RR6	N-terminal editing domain of threonyl-tRNA synthetase from Aeropyrum pernix with L-Ser3AA (snapshot 1) Descriptor: Probable threonine--tRNA ligase 2, SERINE-3'-AMINOADENOSINE Authors: Ahmad, S, Muthukumar, S, Yerabham, A.S.K, Kamarthapu, V, Sankaranarayanan, R. Deposit date: 2014-11-06 Release date: 2015-07-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Specificity and catalysis hardwired at the RNA-protein interface in a translational proofreading enzyme. Nat Commun, 6, 2015
4RRQ	K121M mutant of N-terminal editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi with L-Ser3AA Descriptor: SERINE-3'-AMINOADENOSINE, Threonine--tRNA ligase Authors: Hussain, T, Kamarthapu, V, Sankaranarayanan, R. Deposit date: 2014-11-06 Release date: 2015-07-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Specificity and catalysis hardwired at the RNA-protein interface in a translational proofreading enzyme. Nat Commun, 6, 2015
2OAX	Crystal structure of the S810L mutant mineralocorticoid receptor associated with SC9420 Descriptor: Mineralocorticoid receptor, SPIRONOLACTONE Authors: Huyet, J, Pinon, G.M, Fay, M.R, Rafestin-Oblin, M.E, Fagart, J. Deposit date: 2006-12-18 Release date: 2007-08-14 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Structural basis of spirolactone recognition by the mineralocorticoid receptor Mol.Pharmacol., 72, 2007
1L1F	Structure of human glutamate dehydrogenase-apo form Descriptor: Glutamate Dehydrogenase 1 Authors: Smith, T.J, Schmidt, T, Fang, J, Wu, J, Siuzdak, G, Stanley, C.A. Deposit date: 2002-02-15 Release date: 2002-03-06 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The structure of apo human glutamate dehydrogenase details subunit communication and allostery. J.Mol.Biol., 318, 2002
1DRE	DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) Descriptor: DIHYDROFOLATE REDUCTASE, METHOTREXATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Sawaya, M.R, Kraut, J. Deposit date: 1996-11-28 Release date: 1997-03-12 Last modified: 2024-12-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
2DVP	Structure of NTPase from Pyroccous horikoshii Descriptor: Hypothetical protein PH1917 Authors: Lokanath, N.K, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-07-31 Release date: 2007-09-04 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structures of dimeric nonstandard nucleotide triphosphate pyrophosphatase from Pyrococcus horikoshii OT3: functional significance of interprotomer conformational changes J.Mol.Biol., 375, 2008
5EXL	FACTOR XIA IN COMPLEX WITH THE INHIBITOR 4-(aminomethyl)-~{N}-[(1~{S})-1-[4-(3-oxidanyl-1~{H}-indazol-5-yl)pyridin-2-yl]-2-phenyl-ethyl]cyclohexane-1-carboxamide Descriptor: 1,2-ETHANEDIOL, 4-(aminomethyl)-~{N}-[(1~{S})-1-[4-(3-oxidanyl-1~{H}-indazol-5-yl)pyridin-2-yl]-2-phenyl-ethyl]cyclohexane-1-carboxamide, Coagulation factor XIa light chain, ... Authors: Wei, A. Deposit date: 2015-11-23 Release date: 2016-04-13 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group Bioorg.Med.Chem., 24, 2016
6UJB	Integrin alpha-v beta-8 in complex with the Fabs C6D4 and 11D12v2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C6D4 heavy chain Fab, ... Authors: Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L. Deposit date: 2019-10-02 Release date: 2020-02-05 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (3.51 Å) Cite: Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta. Cell, 180, 2020
6CD9	GID4 in complex with a peptide Descriptor: Glucose-induced degradation protein 4 homolog, Tetrapeptide PSRW, UNKNOWN ATOM OR ION Authors: Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2018-02-08 Release date: 2018-03-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. Nat. Chem. Biol., 14, 2018
3R8D	Activation of the Human Nuclear Xenobiotic Receptor PXR by the Reverse Transcriptase-Targeted Anti-HIV Drug PNU-142721 Descriptor: 6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANYL)-PYRIMIDIN-4-YLAMINE, Nuclear receptor subfamily 1 group I member 2 Authors: Cheng, Y, Redinbo, M.R. Deposit date: 2011-03-23 Release date: 2011-08-17 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Protein Sci., 20, 2011
1EN7	ENDONUCLEASE VII (ENDOVII) FROM PHAGE T4 Descriptor: CALCIUM ION, RECOMBINATION ENDONUCLEASE VII, ZINC ION Authors: Raaijmakers, H, Vix, O, Toro, I, Suck, D. Deposit date: 1999-02-07 Release date: 2000-02-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.4 Å) Cite: X-ray structure of T4 endonuclease VII: a DNA junction resolvase with a novel fold and unusual domain-swapped dimer architecture. EMBO J., 18, 1999
5EXM	FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl ~{N}-[4-[2-[(1~{S})-1-[[4-(aminomethyl)cyclohexyl]carbonylamino]-2-phenyl-ethyl]pyridin-4-yl]phenyl]carbamate Descriptor: 1,2-ETHANEDIOL, Coagulation factor XIa light chain, SULFATE ION, ... Authors: Wei, A. Deposit date: 2015-11-23 Release date: 2016-04-13 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group Bioorg.Med.Chem., 24, 2016
2KXD	The structure of SH3-F2 Descriptor: 11-mer peptide,Spectrin alpha chain, non-erythrocytic 1,Spectrin alpha chain, non-erythrocytic 1 Authors: Kutyshenko, V.P, Gushchina, L.V, Khristoforov, V.S, Prokhorov, D.A, Timchenko, M.A, Kudrevatykh, I.u.A, Fedyukina, D.V, Filimonov, V.V. Deposit date: 2010-04-30 Release date: 2011-04-20 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: NMR structure and dynamics of the chimeric protein SH3-F2 Mol.Biol.(Engl.Transl.), 44, 2010

<1025102610271028102910301031103210331034103510361037103810391040>