7PUO
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![BU of 7puo by Molmil](/molmil-images/mine/7puo) | Structure of a fused 4-OT variant engineered for asymmetric Michael addition reactions | Descriptor: | 2-hydroxymuconate tautomerase,Chains: A,B,C,D,E,F,2-hydroxymuconate tautomerase, CHLORIDE ION, GLYCEROL | Authors: | Rozeboom, H.J, Thunnissen, A.M.W.H, Poelarends, G.J. | Deposit date: | 2021-09-30 | Release date: | 2022-01-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C-C Bond-Forming Enzyme. Angew.Chem.Int.Ed.Engl., 61, 2022
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1S0Y
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![BU of 1s0y by Molmil](/molmil-images/mine/1s0y) | The structure of trans-3-chloroacrylic acid dehalogenase, covalently inactivated by the mechanism-based inhibitor 3-bromopropiolate at 2.3 Angstrom resolution | Descriptor: | MALONIC ACID, alpha-subunit of trans-3-chloroacrylic acid dehalogenase, beta-subunit of trans-3-chloroacrylic acid dehalogenase | Authors: | de Jong, R.M, Brugman, W, Poelarends, G.J, Whitman, C.P, Dijkstra, B.W. | Deposit date: | 2004-01-05 | Release date: | 2004-02-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The X-ray structure of trans-3-chloroacrylic acid dehalogenase reveals a novel hydration mechanism in the tautomerase superfamily J.Biol.Chem., 279, 2004
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4X1C
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![BU of 4x1c by Molmil](/molmil-images/mine/4x1c) | |
7M59
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![BU of 7m59 by Molmil](/molmil-images/mine/7m59) | |
6OGM
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![BU of 6ogm by Molmil](/molmil-images/mine/6ogm) | Crystal structure of apo unFused 4-OT | Descriptor: | 4-oxalocrotonate tautomerase, GLYCEROL | Authors: | Medellin, B.P, Whitman, C.P, Zhang, Y.J. | Deposit date: | 2019-04-03 | Release date: | 2020-02-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.865 Å) | Cite: | Structural, Kinetic, and Mechanistic Analysis of an Asymmetric 4-Oxalocrotonate Tautomerase Trimer. Biochemistry, 58, 2019
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7XUY
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![BU of 7xuy by Molmil](/molmil-images/mine/7xuy) | |
2FM7
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![BU of 2fm7 by Molmil](/molmil-images/mine/2fm7) | |
1BJP
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![BU of 1bjp by Molmil](/molmil-images/mine/1bjp) | CRYSTAL STRUCTURE OF 4-OXALOCROTONATE TAUTOMERASE INACTIVATED BY 2-OXO-3-PENTYNOATE AT 2.4 ANGSTROMS RESOLUTION | Descriptor: | 2-OXO-3-PENTENOIC ACID, 4-OXALOCROTONATE TAUTOMERASE | Authors: | Taylor, A.B, Czerwinski, R.M, Johnson Junior, W.H, Whitman, C.P, Hackert, M.L. | Deposit date: | 1998-06-26 | Release date: | 1998-12-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of 4-oxalocrotonate tautomerase inactivated by 2-oxo-3-pentynoate at 2.4 A resolution: analysis and implications for the mechanism of inactivation and catalysis. Biochemistry, 37, 1998
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1OTF
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![BU of 1otf by Molmil](/molmil-images/mine/1otf) | 4-OXALOCROTONATE TAUTOMERASE-TRICLINIC CRYSTAL FORM | Descriptor: | 4-OXALOCROTONATE TAUTOMERASE | Authors: | Subramanya, H.S, Roper, D.I, Dauter, Z, Dodson, E.J, Davies, G.J, Wilson, K.S, Wigley, D.B. | Deposit date: | 1995-11-09 | Release date: | 1996-04-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases. Biochemistry, 35, 1996
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4X19
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![BU of 4x19 by Molmil](/molmil-images/mine/4x19) | |
3RY0
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![BU of 3ry0 by Molmil](/molmil-images/mine/3ry0) | Crystal structure of TomN, a 4-Oxalocrotonate Tautomerase homologue in Tomaymycin biosynthetic pathway | Descriptor: | Putative tautomerase | Authors: | Zhang, Y, Yan, W.P, Li, W.Z, Whitman, C.P. | Deposit date: | 2011-05-10 | Release date: | 2011-08-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Kinetic, Crystallographic, and Mechanistic Characterization of TomN: Elucidation of a Function for a 4-Oxalocrotonate Tautomerase Homologue in the Tomaymycin Biosynthetic Pathway. Biochemistry, 50, 2011
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5TIG
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![BU of 5tig by Molmil](/molmil-images/mine/5tig) | |
5CLO
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![BU of 5clo by Molmil](/molmil-images/mine/5clo) | |
5CLN
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![BU of 5cln by Molmil](/molmil-images/mine/5cln) | |
6FPS
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![BU of 6fps by Molmil](/molmil-images/mine/6fps) | |
4FDX
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![BU of 4fdx by Molmil](/molmil-images/mine/4fdx) | |
4FAZ
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![BU of 4faz by Molmil](/molmil-images/mine/4faz) | |
6VVR
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![BU of 6vvr by Molmil](/molmil-images/mine/6vvr) | |
6BGN
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![BU of 6bgn by Molmil](/molmil-images/mine/6bgn) | Crystal Structure of 4-Oxalocrotonate Tautomerase After Incubation with 5-Fluoro-2-hydroxy-2,4-pentadienoate | Descriptor: | 2-hydroxymuconate tautomerase, 5-fluoranyl-2-oxidanylidene-pentanoic acid, GLYCEROL, ... | Authors: | Zhang, Y, Li, W, Stack, T. | Deposit date: | 2017-10-29 | Release date: | 2018-02-21 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Inactivation of 4-Oxalocrotonate Tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates. Biochemistry, 57, 2018
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2X4K
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![BU of 2x4k by Molmil](/molmil-images/mine/2x4k) | Crystal structure of SAR1376, a putative 4-oxalocrotonate tautomerase from the methicillin-resistant Staphylococcus aureus (MRSA) | Descriptor: | 4-OXALOCROTONATE TAUTOMERASE, ACETATE ION, PHOSPHATE ION, ... | Authors: | Oke, M, Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, White, M.F, Naismith, J.H. | Deposit date: | 2010-02-01 | Release date: | 2010-07-21 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | The Scottish Structural Proteomics Facility: Targets, Methods and Outputs. J.Struct.Funct.Genomics, 11, 2010
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5UNQ
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![BU of 5unq by Molmil](/molmil-images/mine/5unq) | |
6GHW
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![BU of 6ghw by Molmil](/molmil-images/mine/6ghw) | Substituting the prolines of 4-oxalocrotonate tautomerase with non-canonical analogue (2S)-3,4-dehydroproline | Descriptor: | 2-hydroxymuconate tautomerase, CALCIUM ION | Authors: | Pavkov-Keller, T, Lukesch, M.S, Wiltschi, B, Gruber, K. | Deposit date: | 2018-05-09 | Release date: | 2019-03-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Substituting the catalytic proline of 4-oxalocrotonate tautomerase with non-canonical analogues reveals a finely tuned catalytic system. Sci Rep, 9, 2019
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6VVW
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6BLM
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![BU of 6blm by Molmil](/molmil-images/mine/6blm) | |
3ABF
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![BU of 3abf by Molmil](/molmil-images/mine/3abf) | |