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Crystal structure of the E. coli ribosome bound to CEM-101
Descriptor: (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-{4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl}-4-ethyl-7-fluoro-11-methoxy-3a ,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside, 16S rRNA, 23S rRNA, ...
Authors:Dunkle, J.A, Zhang, W, Cate, J.H.D, Mankin, A.S.
Deposit date:2014-11-12
Release date:2014-12-24
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.
Antimicrob. Agents Chemother., 54, 2010

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