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PDB: 1 results

7O2I
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BU of 7o2i by Molmil
METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM2457
Descriptor: DIMETHYL SULFOXIDE, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, ...
Authors:Pilka, E.S, Blackaby, W, Hardick, D, Harper, C, Hewstone, D, Ridgill, M, Rotty, B, Rausch, O.
Deposit date:2021-03-30
Release date:2021-04-14
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Nature, 593, 2021

238582

数据于2025-07-09公开中

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