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PDB: 1 results

5UOO
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BRD4 bromodomain 2 in complex with CD161
Descriptor: 7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indole, Bromodomain-containing protein 4
Authors:Meagher, J.L, Stuckey, J.A.
Deposit date:2017-02-01
Release date:2017-05-17
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.
J. Med. Chem., 60, 2017

227344

数据于2024-11-13公开中

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