9BRG
 
 | | Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL055-22 | | Descriptor: | (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-({4-[(furan-2-carbonyl)amino]-3,5-dimethyl-1H-pyrrol-2-yl}methylidene)-2-oxo-3,7-dihydro-2H-indole-5-carboxamide, G protein-coupled receptor kinase 5 | | Authors: | Chen, Y, Tesmer, J.J.G. | | Deposit date: | 2024-05-11 | | Release date: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors.
Eur.J.Med.Chem., 282, 2025
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9BRH
 | | Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL056-21 | | Descriptor: | (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-({4-[(furan-3-carbonyl)amino]-3,5-dimethyl-1H-pyrrol-2-yl}methylidene)-2-oxo-3,7-dihydro-2H-indole-5-carboxamide, G protein-coupled receptor kinase 5 | | Authors: | Chen, Y, Tesmer, J.J.G. | | Deposit date: | 2024-05-11 | | Release date: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (3.69 Å) | | Cite: | Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors.
Eur.J.Med.Chem., 282, 2025
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9BRI
 | | Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL064-22 | | Descriptor: | (3Z)-3-[(3,5-dimethyl-4-{[(2S)-5-oxooxolane-2-carbonyl]amino}-1H-pyrrol-2-yl)methylidene]-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5 | | Authors: | Chen, Y, Tesmer, J.J.G. | | Deposit date: | 2024-05-11 | | Release date: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors.
Eur.J.Med.Chem., 282, 2025
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9BRE
 | | Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL019-21 | | Descriptor: | (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[(4-{[(2S)-2-(furan-2-yl)-2-hydroxyacetyl]amino}-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5 | | Authors: | Chen, Y, Tesmer, J.J.G. | | Deposit date: | 2024-05-11 | | Release date: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors.
Eur.J.Med.Chem., 282, 2025
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9BRJ
 | | Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL093-22 | | Descriptor: | (4S)-N-{5-[(Z)-(5-{[(1R)-1-(4-fluorophenyl)ethyl]carbamoyl}-2-oxo-2,7-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-yl}-2-methylimidazo[1,2-a]pyridine-3-carboxamide, G protein-coupled receptor kinase 5 | | Authors: | Chen, Y, Tesmer, J.J.G. | | Deposit date: | 2024-05-11 | | Release date: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors.
Eur.J.Med.Chem., 282, 2025
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