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7S6M
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BU of 7s6m by Molmil
Human PARP1 deltaV687-E688 bound to a DNA double strand break.
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*CP*G)-3'), ...
Authors:Rouleau-Turcotte, E, Pascal, J.M.
Deposit date:2021-09-14
Release date:2022-06-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
Mol.Cell, 82, 2022
8C7O
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BU of 8c7o by Molmil
Unliganded transcriptional pleiotropic repressor CodY from Staphylococcus aureus
Descriptor: ACETATE ION, Global transcriptional regulator CodY, SULFATE ION
Authors:Hainzl, T, Sauer-Eriksson, A.E.
Deposit date:2023-01-16
Release date:2023-06-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural insights into CodY activation and DNA recognition.
Nucleic Acids Res., 51, 2023
7E5W
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BU of 7e5w by Molmil
The structure of CcpA from Staphylococcus aureus
Descriptor: Catabolite control protein A, SULFATE ION
Authors:Yu, G, Wei, X.
Deposit date:2021-02-20
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Regulation of DNA-binding activity of the Staphylococcus aureus catabolite control protein A by copper (II)-mediated oxidation.
J.Biol.Chem., 298, 2022
6LTP
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BU of 6ltp by Molmil
Crystal structure of Cas12i2 binary complex
Descriptor: Cas12i2, crRNA (56-mer RNA)
Authors:Huang, X, Sun, W, Cheng, Z, Chen, M, Li, X, Wang, J, Sheng, G, Gong, W, Wang, Y.
Deposit date:2020-01-23
Release date:2020-10-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2.
Nat Commun, 11, 2020
2MAM
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BU of 2mam by Molmil
Solution structure of the interdigitated double Tudor domain of RBBP1
Descriptor: AT-rich interactive domain-containing protein 4A
Authors:Gong, W, Feng, Y.
Deposit date:2013-07-15
Release date:2014-01-15
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Retinoblastoma-binding protein 1 has an interdigitated double Tudor domain with DNA binding activity.
J.Biol.Chem., 289, 2014
5FTC
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BU of 5ftc by Molmil
Crystal structure of Pif1 helicase from Bacteroides in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, TPR DOMAIN PROTEIN
Authors:Chen, W.-F, Dai, Y.-X, Duan, X.-L, Liu, N.-N, Shi, W, Li, M, Dou, S.-X, Li, N, Dong, Y.-H, Rety, S, Xi, X.-G.
Deposit date:2016-01-12
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.269 Å)
Cite:Crystal Structures of the Bspif1 Helicase Reveal that a Major Movement of the 2B SH3 Domain is Required for DNA Unwinding
Nucleic Acids Res., 44, 2016
3FGH
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BU of 3fgh by Molmil
Human mitochondrial transcription factor A box B
Descriptor: CADMIUM ION, CHLORIDE ION, SODIUM ION, ...
Authors:Gangelhoff, T.A, Mungalachetty, P, Nix, J, Churchill, M.E.A.
Deposit date:2008-12-06
Release date:2009-04-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural analysis and DNA binding of the HMG domains of the human mitochondrial transcription factor A
Nucleic Acids Res., 37, 2009
5FTD
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BU of 5ftd by Molmil
Crystal structure of Pif1 helicase from Bacteroides apo form
Descriptor: PHOSPHATE ION, TPR DOMAIN PROTEIN
Authors:Chen, W.-F, Dai, Y.-X, Duan, X.-L, Liu, N.-N, Shi, W, Li, M, Dou, S.-X, Li, N, Dong, Y.-H, Rety, S, Xi, X.-G.
Deposit date:2016-01-12
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.695 Å)
Cite:Crystal Structures of the Bspif1 Helicase Reveal that a Major Movement of the 2B SH3 Domain is Required for DNA Unwinding
Nucleic Acids Res., 44, 2016
5FTF
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BU of 5ftf by Molmil
Crystal structure of Pif1 helicase from Bacteroides double mutant L95C-I339C
Descriptor: ADENOSINE-5'-DIPHOSPHATE, TPR DOMAIN PROTEIN
Authors:Chen, W.-F, Dai, Y.-X, Duan, X.-L, Liu, N.-N, Shi, W, Li, M, Dou, S.-X, Li, N, Dong, Y.-H, Rety, S, Xi, X.-G.
Deposit date:2016-01-13
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.412 Å)
Cite:Crystal Structures of the Bspif1 Helicase Reveal that a Major Movement of the 2B SH3 Domain is Required for DNA Unwinding
Nucleic Acids Res., 44, 2016
6G6J
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BU of 6g6j by Molmil
The crystal structures of Human MYC:MAX bHLHZip complex
Descriptor: Myc proto-oncogene protein, Protein max, SULFATE ION
Authors:Allen, M.D, Zinzalla, G.
Deposit date:2018-04-01
Release date:2019-04-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA.
Biochemistry, 58, 2019
7P3F
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BU of 7p3f by Molmil
Streptomyces coelicolor dATP/ATP-loaded NrdR in complex with its cognate DNA
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (50-MER), ...
Authors:Martinez-Carranza, M, Stenmark, P.
Deposit date:2021-07-07
Release date:2022-05-11
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases.
Nat Commun, 13, 2022
6G6K
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BU of 6g6k by Molmil
The crystal structures of Human MYC:MAX bHLHZip complex
Descriptor: CHLORIDE ION, Myc proto-oncogene protein, Protein max
Authors:Allen, M.D, Zinzalla, G.
Deposit date:2018-04-01
Release date:2019-04-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA.
Biochemistry, 58, 2019
3MUJ
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BU of 3muj by Molmil
Early B-cell factor 3 (EBF3) IPT/TIG and dimerization helices
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Transcription factor COE3
Authors:Siponen, M.I, Lehtio, L, Arrowsmith, C.H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Karlberg, T, Kotenyova, T, Moche, M, Nordlund, P, Nyman, T, Persson, C, Schueler, H, Schutz, P, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Wisniewska, M, Berglund, H, Structural Genomics Consortium (SGC)
Deposit date:2010-05-03
Release date:2010-06-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif.
J.Biol.Chem., 285, 2010
6G6L
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BU of 6g6l by Molmil
The crystal structures of Human MYC:MAX bHLHZip complex
Descriptor: Myc proto-oncogene protein, Protein max, SULFATE ION
Authors:Allen, M.D, Zinzalla, G.
Deposit date:2018-04-01
Release date:2019-04-10
Last modified:2023-04-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA.
Biochemistry, 58, 2019
4G0V
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BU of 4g0v by Molmil
Human topoisomerase iibeta in complex with DNA and mitoxantrone
Descriptor: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.548 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
5FTB
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BU of 5ftb by Molmil
Crystal structure of Pif1 helicase from Bacteroides in complex with AMPPNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, POTASSIUM ION, ...
Authors:Chen, W.-F, Dai, Y.-X, Duan, X.-L, Liu, N.-N, Shi, W, Li, M, Dou, S.-X, Li, N, Dong, Y.-H, Rety, S, Xi, X.-G.
Deposit date:2016-01-12
Release date:2016-02-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Crystal Structures of the Bspif1 Helicase Reveal that a Major Movement of the 2B SH3 Domain is Required for DNA Unwinding
Nucleic Acids Res., 44, 2016
7D11
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BU of 7d11 by Molmil
Solution structure of a WKRY DNA-binding domain
Descriptor: WRKY transcription factor 1, ZINC ION
Authors:Li, Q.W, Hu, Y.F, Jin, C.W.
Deposit date:2020-09-12
Release date:2021-09-15
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structure of a WKRY DNA-binding domain
To Be Published
1D1M
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BU of 1d1m by Molmil
CRYSTAL STRUCTURE OF CRO K56-[DGEVK]-F58W MUTANT
Descriptor: LAMBDA CRO REPRESSOR
Authors:Rupert, P.B, Mollah, A.K, Mossing, M.C, Matthews, B.W.
Deposit date:1999-09-17
Release date:1999-09-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The structural basis for enhanced stability and reduced DNA binding seen in engineered second-generation Cro monomers and dimers.
J.Mol.Biol., 296, 2000
4K8F
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BU of 4k8f by Molmil
Structure of the heme domain of CooA from Rhodospirillum rubrum
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, Transcriptional regulator, Crp/Fnr family
Authors:Kuchinskas, M, Li, H, Poulos, T.L.
Deposit date:2013-04-18
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The role of the DNA-binding domains in CooA activation.
Biochemistry, 45, 2006
6M9K
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BU of 6m9k by Molmil
Crystal structure of lambda exonuclease in complex with the Red beta C-terminal domain
Descriptor: Exonuclease, Recombination protein bet, SULFATE ION
Authors:Bell, C.E, Caldwell, B.J.
Deposit date:2018-08-23
Release date:2019-01-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Red beta C-terminal domain in complex with lambda Exonuclease reveals an unexpected homology with lambda Orf and an interaction with Escherichia coli single stranded DNA binding protein.
Nucleic Acids Res., 47, 2019
7KLF
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BU of 7klf by Molmil
Ternary structure of Dpo4 bound to G in the template base paired with incoming dCTP
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*TP*AP*AP*CP*GP*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ...
Authors:Koag, M.-C, Lee, S.
Deposit date:2020-10-30
Release date:2021-11-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structure of human DNA polymerase beta complexed with 8OA in the template base paired with incoming non-hydrolyzable ATP
To Be Published
7KLE
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BU of 7kle by Molmil
Ternary structure of Dpo4 bound to N7mG in the template base paired with incoming dCTP
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*TP*AP*AP*CP*(FMG)P*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ...
Authors:Koag, M.-C, Lee, S.
Deposit date:2020-10-30
Release date:2021-11-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.003 Å)
Cite:Structure of human DNA polymerase beta complexed with 8OA in the template base paired with incoming non-hydrolyzable ATP
To Be Published
5OFN
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BU of 5ofn by Molmil
Crystal structure of the heterotrimeric PriSLX primase from S. solfataricus.
Descriptor: DNA primase large subunit PriL,PriL-X fusion protein, DNA primase small subunit PriS, ZINC ION
Authors:Pellegrini, L, Holzer, S.
Deposit date:2017-07-11
Release date:2017-11-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster.
Nat Commun, 8, 2017
6WAF
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BU of 6waf by Molmil
Crystal Structure of SmcR N55I from Vibrio vulnificus
Descriptor: LuxR family transcriptional regulator, SULFATE ION
Authors:Newman, J.D, Russell, M.M, Gonzalez-Gutierrez, G, van Kessel, J.C.
Deposit date:2020-03-25
Release date:2020-06-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.381 Å)
Cite:The DNA binding domain of the Vibrio vulnificus SmcR transcription factor is flexible and binds diverse DNA sequences.
Nucleic Acids Res., 49, 2021
6WAH
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BU of 6wah by Molmil
Crystal Structure of SmcR L139R from Vibrio vulnificus
Descriptor: 1,2-ETHANEDIOL, LuxR family transcriptional regulator, SULFATE ION
Authors:Newman, J.D, Russell, M.M, Gonzalez-Gutierrez, G, van Kessel, J.C.
Deposit date:2020-03-25
Release date:2020-06-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The DNA binding domain of the Vibrio vulnificus SmcR transcription factor is flexible and binds diverse DNA sequences.
Nucleic Acids Res., 49, 2021

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