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6JSZ
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BU of 6jsz by Molmil
BACE2 xaperone complex with N-{3-[(5R)-3-amino-5-methyl-9,9-dioxo-2,9lambda6-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide
Descriptor: Beta-secretase 2, CHLORIDE ION, N-[3-[(5R)-3-azanyl-5-methyl-9,9-bis(oxidanylidene)-2,9$l^{6}-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluoranyl-phenyl]-5-(fluoranylmethoxy)pyrazine-2-carboxamide, ...
Authors:Fujimoto, K, Matsuoka, E, Asada, N, Tadano, G, Yamamoto, T, Nakahara, K, Fuchino, K, Ito, H, Kanegawa, N, Moechars, D, Gijsen, H.J.M, Kusakabe, K.I.
Deposit date:2019-04-08
Release date:2019-08-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Structure-Based Design of Selective beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2.
J.Med.Chem., 62, 2019
6JT4
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BU of 6jt4 by Molmil
Crystal Structure of BACE1 in complex with N-{3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide
Descriptor: Beta-secretase 1, GLYCEROL, IODIDE ION, ...
Authors:Anan, K, Iso, Y, Oguma, T, Nakahara, K, Suzuki, S, Yamamoto, T, Matsuoka, E, Ito, H, Sakaguchi, G, Ando, S, Morimoto, K, Kanegawa, N, Kido, Y, Kawachi, T, Fukushima, T, Teisman, A, Urmaliya, V, Dhuyvetter, D, Borghys, H, Austin, N, Bergh, A.V.D, Verboven, P, Bischoff, F, Gijsen, H.J.M, Yamano, Y, Kusakabe, K.I.
Deposit date:2019-04-08
Release date:2020-01-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Trifluoromethyl Dihydrothiazine-Based beta-Secretase (BACE1) Inhibitors with Robust Central beta-Amyloid Reduction and Minimal Covalent Binding Burden.
Chemmedchem, 14, 2019
6JSN
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BU of 6jsn by Molmil
Crystal Structure of BACE1 in complex with N-{3-[(5R)-3-amino-5-methyl-9,9-dioxo-2,9lambda6-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide
Descriptor: Beta-secretase 1, GLYCEROL, IODIDE ION, ...
Authors:Fujimoto, K, Matsuoka, E, Asada, N, Tadano, G, Yamamoto, T, Nakahara, K, Fuchino, K, Ito, H, Kanegawa, N, Moechars, D, Gijsen, H.J.M, Kusakabe, K.I.
Deposit date:2019-04-08
Release date:2019-08-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Based Design of Selective beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2.
J.Med.Chem., 62, 2019
6ZZ2
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BU of 6zz2 by Molmil
Cocktail experiment E: fragments 52, 58, and 63 at 90 mM concentration in complex with Endothiapepsin
Descriptor: DIMETHYL SULFOXIDE, Endothiapepsin, GLYCEROL, ...
Authors:Hassaan, E, Klebe, G, Heine, A, Schiebel, J, Koester, H.
Deposit date:2020-08-03
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.14885437 Å)
Cite:Cocktail experiment E: fragments 52, 58, and 63 at 90 mM concentration in complex with Endothiapepsin
To Be Published
8CIK
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BU of 8cik by Molmil
Altai wapiti (Cervus elaphus sibiricus) chymosin at 2.2 A resolution
Descriptor: Chymosin, GLYCEROL
Authors:Diusenova, S.E, Shevtsov, M.B, Borshchevskiy, V.I, Belenkaya, S.V, Kolybalov, D.S, Arkhipov, S.G, Volosnikova, E.A, Elchaninov, V.V, Shcherbakov, D.N.
Deposit date:2023-02-09
Release date:2023-03-08
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Altai wapiti (Cervus elaphus sibiricus) chymosin at 2.2 A resolution
To Be Published
7ADG
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BU of 7adg by Molmil
Cocktail experiment G: fragments 216 and 338 at 90 mM concentration in complex with Endothiapepsin
Descriptor: 2-(1H-imidazol-1-yl)-N-(trans-4-methylcyclohexyl)acetamide, ACETATE ION, DIMETHYL SULFOXIDE, ...
Authors:Hassaan, E, Klebe, G, Heine, A, Schiebel, J, Koester, H.
Deposit date:2020-09-14
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.0794636 Å)
Cite:Comparison of Cocktail Screening in X-Ray Crystallography vs NMR
To Be Published
6KUC
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BU of 6kuc by Molmil
Crystal structure of Plasmodium falciparum histo-aspartic protease (HAP) zymogen (Form 2)
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, HAP protein
Authors:Rathore, I, Mishra, V, Bhaumik, P.
Deposit date:2019-08-31
Release date:2020-05-27
Last modified:2021-02-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway.
Febs J., 288, 2021
6KUD
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BU of 6kud by Molmil
Crystal structure of Plasmodium falciparum histo-aspartic protease (HAP) zymogen (Form 3)
Descriptor: GLYCEROL, HAP protein
Authors:Rathore, I, Mishra, V, Bhaumik, P.
Deposit date:2019-08-31
Release date:2020-05-27
Last modified:2021-02-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway.
Febs J., 288, 2021
6KUB
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BU of 6kub by Molmil
Crystal structure of Plasmodium falciparum histo-aspartic protease (HAP) zymogen (Form 1)
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, HAP protein
Authors:Rathore, I, Mishra, V, Bhaumik, P.
Deposit date:2019-08-31
Release date:2020-05-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway.
Febs J., 288, 2021
8C6P
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BU of 8c6p by Molmil
Fragment screening hit I bound to endothiapepsin
Descriptor: 4-[(2-azanyl-4-methyl-1,3-thiazol-5-yl)methyl]benzenecarbonitrile, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C6Q
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BU of 8c6q by Molmil
Fragment screening hit II bound to endothiapepsin
Descriptor: 3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)aniline, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C71
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BU of 8c71 by Molmil
Pyrrolidine fragment 5b bound to endothiapepsin
Descriptor: (3~{R},4~{R})-4-(3,4-dihydro-1~{H}-isoquinolin-2-yl)pyrrolidin-3-ol, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C70
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BU of 8c70 by Molmil
Pyrrolidine fragment 1 bound to endothiapepsin
Descriptor: (3~{R},4~{R})-4-[4-[(5-bromanylpyridin-3-yl)oxymethyl]-1,2,3-triazol-1-yl]pyrrolidin-3-ol, Endothiapepsin
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C72
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BU of 8c72 by Molmil
Pyrrolidine fragment 10b bound to endothiapepsin
Descriptor: (3~{S},4~{S})-4-(4-pyridin-2-yl-1,2,3-triazol-1-yl)piperidin-3-ol, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C74
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BU of 8c74 by Molmil
Pyrrolidine fragment 10d bound to endothiapepsin
Descriptor: (3~{R},4~{R})-4-[4-[(4-azanylphenoxy)methyl]-1,2,3-triazol-1-yl]pyrrolidin-3-ol, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C6S
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BU of 8c6s by Molmil
Fragment screening hit III bound to endothiapepsin
Descriptor: 4-(1,4-diazepan-1-ylsulfonyl)isoquinoline, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
8C6T
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BU of 8c6t by Molmil
Fragment screening hit IV bound to endothiapepsin
Descriptor: 1-[3,5-bis(chloranyl)phenoxy]propan-2-amine, Endothiapepsin, GLYCEROL
Authors:Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D.
Deposit date:2023-01-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library.
J.Med.Chem., 66, 2023
7AGB
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BU of 7agb by Molmil
Protease Sapp1p from Candida parapsilosis in complex with KB70
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, Candidapepsin, ...
Authors:Dostal, J, Heidingsfeld, O, Brynda, J.
Deposit date:2020-09-22
Release date:2021-04-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis .
J Enzyme Inhib Med Chem, 36, 2021
7AGE
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BU of 7age by Molmil
Protease Sapp1p from Candida parapsilosis in complex with KB32
Descriptor: Candidapepsin, DI(HYDROXYETHYL)ETHER, Pepstatin
Authors:Dostal, J, Heidingsfeld, O, Brynda, J.
Deposit date:2020-09-22
Release date:2021-04-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis .
J Enzyme Inhib Med Chem, 36, 2021
7AGD
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BU of 7agd by Molmil
Protease Sapp1p from Candida parapsilosis in complex with KB75
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Candidapepsin, DI(HYDROXYETHYL)ETHER, ...
Authors:Dostal, J, Heidingsfeld, O, Brynda, J.
Deposit date:2020-09-22
Release date:2021-04-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis .
J Enzyme Inhib Med Chem, 36, 2021
7AGC
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BU of 7agc by Molmil
Protease Sapp1p from Candida parapsilosis in complex with KB74
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Candidapepsin, DI(HYDROXYETHYL)ETHER, ...
Authors:Dostal, J, Heidingsfeld, O, Brynda, J.
Deposit date:2020-09-22
Release date:2021-04-21
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis .
J Enzyme Inhib Med Chem, 36, 2021
7B1P
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BU of 7b1p by Molmil
Crystal Structure of Human BACE-1 in Complex with Compound 38a (NB-854)
Descriptor: Beta-secretase 1, ~{N}-[3-[(3~{R},6~{R})-5-azanyl-3,6-dimethyl-6-(trifluoromethyl)-2~{H}-1,4-oxazin-3-yl]phenyl]-5-bromanyl-pyridine-2-carboxamide
Authors:Rondeau, J.M, Wirth, E.
Deposit date:2020-11-25
Release date:2021-04-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Synthesis of the Potent, Selective, and Efficacious beta-Secretase (BACE1) Inhibitor NB-360.
J.Med.Chem., 64, 2021
7B1Q
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BU of 7b1q by Molmil
Crystal Structure of Human BACE-1 in Complex with Compound NB-360 (compound 54)
Descriptor: Beta-secretase 1, ~{N}-[3-[(3~{R},6~{R})-5-azanyl-3,6-dimethyl-6-(trifluoromethyl)-2~{H}-1,4-oxazin-3-yl]-4-fluoranyl-phenyl]-5-cyano-3-methyl-pyridine-2-carboxamide
Authors:Rondeau, J.M, Wirth, E.
Deposit date:2020-11-25
Release date:2021-04-28
Last modified:2021-05-05
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Synthesis of the Potent, Selective, and Efficacious beta-Secretase (BACE1) Inhibitor NB-360.
J.Med.Chem., 64, 2021
7B1E
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BU of 7b1e by Molmil
BACE1 IN COMPLEX WITH compound 3 (NB-641)
Descriptor: Beta-secretase 1, ~{N}-[3-[(4~{S})-2-azanyl-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]phenyl]-5-bromanyl-pyridine-2-carboxamide
Authors:Rondeau, J.M, Wirth, E.
Deposit date:2020-11-24
Release date:2021-04-28
Last modified:2021-05-05
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Synthesis of the Potent, Selective, and Efficacious beta-Secretase (BACE1) Inhibitor NB-360.
J.Med.Chem., 64, 2021
2WEC
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BU of 2wec by Molmil
ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE INHIBITOR: METHYL(2S)-[1-(((N-(1-NAPHTHALENEACETYL))-L-VALYL)AMINOMETHYL)HYDROXY PHOSPHINYLOXY]-3-PHENYLPROPANOATE, SODIUM SALT
Descriptor: METHYL (2S)-[1-((N-(NAPHTHALENEACETYL))-L-VALYL)AMINOMETHYL)HYDROXYPHOSPHINYLOXY]-3-PHENYL PROPANOATE, PENICILLOPEPSIN, SULFATE ION, ...
Authors:Ding, J, Fraser, M.E, James, M.N.G.
Deposit date:1998-02-03
Release date:1998-05-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Macrocyclic Inhibitors of Penicillopepsin. II. X-Ray Crystallographic Analyses of Penicillopepsin Complexed with a P3-P1 Macrocyclic Peptidyl Inhibitor and with its Two Acyclic Analogues
J.Am.Chem.Soc., 120, 1998

221716

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