PDB: 22634 resultsInfo pagesStatus searchChemie searchBIRD

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4WYC	Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a thiazole benzamide inhibitor Descriptor: 1,2-ETHANEDIOL, 4-(1H-imidazol-1-yl)benzamide, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, ... Authors: Finzel, B.C, Dai, R, Geders, T.W. Deposit date: 2014-11-17 Release date: 2015-07-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58, 2015
4WZF	Crystal structural basis for Rv0315, an immunostimulatory antigen and pseudo beta-1, 3-glucanase of Mycobacterium tuberculosis Descriptor: 1,2-ETHANEDIOL, 1,3-beta-glucanase, CALCIUM ION Authors: Dong, W.Y, Fu, Z.F, Peng, G.Q. Deposit date: 2014-11-19 Release date: 2015-12-09 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.699 Å) Cite: Crystal structural basis for Rv0315, an immunostimulatory antigen and inactive beta-1,3-glucanase of Mycobacterium tuberculosis. Sci Rep, 5, 2015
1OB2	E. coli elongation factor EF-Tu complexed with the antibiotic kirromycin, a GTP analog, and Phe-tRNA Descriptor: ELONGATION FACTOR TU, KIRROMYCIN, MAGNESIUM ION, ... Authors: Kristensen, O, Nissen, P, Nyborg, J. Deposit date: 2003-01-24 Release date: 2004-05-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Kirromycin Defines a Specific Domain Arrangement of Elongation Factor EF-TU To be Published
4WYD	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase from Mycobacterium tuberculosis complexed with a fragment from DSF screening Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, ... Authors: Dai, R, Finzel, B.C, Geders, T.W. Deposit date: 2014-11-17 Release date: 2015-07-15 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58, 2015
4X0E	Structure of M. tuberculosis nicotinate mono nucleotide adenylyltransferase Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Probable nicotinate-nucleotide adenylyltransferase, SULFATE ION Authors: Zuccola, H.J, Ostermna, A.L. Deposit date: 2014-11-21 Release date: 2015-01-28 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Mycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery. J. Biol. Chem., 290, 2015
8EM5	Mycobacterium thermoresistible MmpS5 Descriptor: DODECAETHYLENE GLYCOL, GLYCEROL, IODIDE ION, ... Authors: Cuthbert, B.J, Goulding, C.W. Deposit date: 2022-09-26 Release date: 2023-09-27 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.95 Å) Cite: The structure of Mycobacterium thermoresistibile MmpS5 reveals a conserved disulfide bond across mycobacteria. Metallomics, 16, 2024
8G08	Cryo-EM structure of SQ31f-bound Mycobacterium smegmatis ATP synthase rotational state 1 (backbone model) Descriptor: 3-[4-(morpholin-4-yl)phenyl]-4-{[(pyridin-2-yl)methyl]amino}cyclobut-3-ene-1,2-dione, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... Authors: Courbon, G.M, Rubinstein, J.L. Deposit date: 2023-01-31 Release date: 2023-02-15 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G09	Cryo-EM structure of SQ31f-bound Mycobacterium smegmatis ATP synthase rotational state 2 (backbone model) Descriptor: 3-[4-(morpholin-4-yl)phenyl]-4-{[(pyridin-2-yl)methyl]amino}cyclobut-3-ene-1,2-dione, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... Authors: Courbon, G.M, Rubinstein, J.L. Deposit date: 2023-01-31 Release date: 2023-02-15 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G0C	Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase rotational state 1 (backbone model) Descriptor: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... Authors: Courbon, G.M, Rubinstein, J.L. Deposit date: 2023-01-31 Release date: 2023-02-15 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G0E	Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase rotational state 3 Descriptor: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... Authors: Courbon, G.M, Rubinstein, J.L. Deposit date: 2023-01-31 Release date: 2023-02-15 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G0A	Cryo-EM structure of SQ31f-bound Mycobacterium smegmatis ATP synthase rotational state 3 Descriptor: 3-[4-(morpholin-4-yl)phenyl]-4-{[(pyridin-2-yl)methyl]amino}cyclobut-3-ene-1,2-dione, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... Authors: Courbon, G.M, Rubinstein, J.L. Deposit date: 2023-01-31 Release date: 2023-02-15 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G0D	Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase rotational state 2 (backbone model) Descriptor: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... Authors: Courbon, G.M, Rubinstein, J.L. Deposit date: 2023-01-31 Release date: 2023-02-15 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G0B	Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase FO region Descriptor: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ATP synthase subunit a, ATP synthase subunit b, ... Authors: Courbon, G.M, Rubinstein, J.L. Deposit date: 2023-01-31 Release date: 2023-02-15 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G07	Cryo-EM structure of SQ31f-bound Mycobacterium smegmatis ATP synthase FO region Descriptor: 3-[4-(morpholin-4-yl)phenyl]-4-{[(pyridin-2-yl)methyl]amino}cyclobut-3-ene-1,2-dione, ATP synthase subunit a, ATP synthase subunit b, ... Authors: Courbon, G.M, Rubinstein, J.L. Deposit date: 2023-01-31 Release date: 2023-02-15 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8D6Y	Structure of the Mycobacterium tuberculosis 20S proteasome bound to the ADP-bound Mpa ATPase Descriptor: AAA ATPase forming ring-shaped complexes, Proteasome subunit alpha, Proteasome subunit beta, ... Authors: Xiao, X, Li, H. Deposit date: 2022-06-06 Release date: 2022-08-03 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (10 Å) Cite: The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation. Msphere, 7, 2022
8D6X	Structure of the Mycobacterium tuberculosis 20S proteasome bound to the ATP-bound Mpa ATPase Descriptor: AAA ATPase forming ring-shaped complexes, Proteasome subunit alpha, Proteasome subunit beta, ... Authors: Xiao, X, Li, H. Deposit date: 2022-06-06 Release date: 2022-08-03 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation. Msphere, 7, 2022
8E74	Mycobacterium tuberculosis RNAP paused elongation complex with NusG transcription factor Descriptor: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Delbeau, M, Darst, S.A, Campbell, E.A. Deposit date: 2022-08-23 Release date: 2023-03-22 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis. Mol.Cell, 83, 2023
8E82	Mycobacterium tuberculosis RNAP elongation complex with NusG transcription factor Descriptor: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Delbeau, M, Darst, S.A, Campbell, E.A. Deposit date: 2022-08-25 Release date: 2023-03-22 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3.03 Å) Cite: Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis. Mol.Cell, 83, 2023
8D6W	Structure of the Mycobacterium tuberculosis 20S proteasome bound to the C-terminal GQYL motif of the ADP-bound Mpa ATPase Descriptor: Proteasome subunit alpha, Proteasome subunit beta, Proteasome-associated ATPase Authors: Xiao, X, Li, H. Deposit date: 2022-06-06 Release date: 2022-08-03 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3 Å) Cite: The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation. Msphere, 7, 2022
8D6V	Structure of the Mycobacterium tuberculosis 20S proteasome bound to the C-terminal GQYL motif of the ATP-bound Mpa ATPase Descriptor: Proteasome subunit alpha, Proteasome subunit beta, Proteasome-associated ATPase Authors: Xiao, X, Li, H. Deposit date: 2022-06-06 Release date: 2022-08-03 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation. Msphere, 7, 2022
8E8M	Mycobacterium tuberculosis RNAP paused elongation complex Descriptor: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Delbeau, M, Darst, S.A, Campbell, E.A. Deposit date: 2022-08-25 Release date: 2023-03-22 Last modified: 2024-10-09 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis. Mol.Cell, 83, 2023
8E95	Mycobacterium tuberculosis RNAP elongation complex Descriptor: DNA (25-MER), DNA (33-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Delbeau, M, Darst, S.A, Campbell, E.A. Deposit date: 2022-08-26 Release date: 2023-03-22 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis. Mol.Cell, 83, 2023
4RRU	Myc3 N-terminal JAZ-binding domain[5-242] from arabidopsis Descriptor: CALCIUM ION, Transcription factor MYC3 Authors: Ke, J, Zhang, F, Zhou, X.E, Brunzelle, J.S, Zhou, M, Xu, H.E, Melcher, K, He, S.Y. Deposit date: 2014-11-06 Release date: 2015-08-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. Nature, 525, 2015
8B9U	Structure of ClpC1 NTD from Mycobacterium tuberculosis Descriptor: (MLE)V(MAA)(E9M)G, ATP-dependent Clp protease ATP-binding subunit ClpC1, FORMIC ACID Authors: Meinhart, A, Hoi, D.M, Clausen, T. Deposit date: 2022-10-10 Release date: 2023-07-05 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival. Cell, 186, 2023
8BTW	Structure of D179N BlaC from Mycobacterium tuberculosis in complex with vaborbactam Descriptor: Beta-lactamase, GLYCEROL, PHOSPHATE ION, ... Authors: Chikunova, A, Bruenle, S, Ubbink, M. Deposit date: 2022-12-02 Release date: 2023-07-05 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Asp179 in the class A beta-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis. Febs J., 290, 2023

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