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6TNZ	Human polymerase delta-FEN1-PCNA toolbelt Descriptor: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ... Authors: Lancey, C, Hamdan, S.M, De Biasio, A. Deposit date: 2019-12-10 Release date: 2019-12-18 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (4.05 Å) Cite: Structure of the processive human Pol delta holoenzyme. Nat Commun, 11, 2020
6V8P	Structure of DNA Polymerase Zeta (Apo) Descriptor: DNA polymerase delta small subunit, DNA polymerase delta subunit 3, DNA polymerase zeta catalytic subunit, ... Authors: Malik, R, Gomez-Llorente, Y, Ubarretxena-Belandia, I, Aggarwal, A.K. Deposit date: 2019-12-11 Release date: 2020-08-19 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structure and mechanism of B-family DNA polymerase zeta specialized for translesion DNA synthesis. Nat.Struct.Mol.Biol., 27, 2020
7LXD	Structure of yeast DNA Polymerase Zeta (apo) Descriptor: DNA polymerase delta small subunit, DNA polymerase delta subunit 3, DNA polymerase zeta catalytic subunit, ... Authors: Truong, C.D, Craig, T.A, Cui, G, Botuyan, M.V, Serkasevich, R.A, Chan, K.-Y, Mer, G, Chiu, P.-L, Kumar, R. Deposit date: 2021-03-03 Release date: 2021-06-30 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.11 Å) Cite: Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta. J.Biol.Chem., 297, 2021
7OPL	CryoEM structure of DNA Polymerase alpha - primase bound to SARS CoV nsp1 Descriptor: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ... Authors: Kilkenny, M.L, Pellegrini, L. Deposit date: 2021-06-01 Release date: 2021-11-10 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (4.12 Å) Cite: Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase alpha-primase. Protein Sci., 31, 2022
6S2E	Cryo-EM structure of Ctf18-1-8 in complex with the catalytic domain of DNA polymerase epsilon Descriptor: Chromosome transmission fidelity protein 18, Chromosome transmission fidelity protein 8, DNA polymerase epsilon catalytic subunit A, ... Authors: Grabarczyk, D.B, Song, B. Deposit date: 2019-06-20 Release date: 2020-07-08 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Ctf18-RFC and DNA Pol ε form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication. Nucleic Acids Res., 48, 2020
7UY7	Tetrahymena CST with Polymerase alpha-Primase Descriptor: DNA polymerase, Telomerase associated protein p50, Telomerase-associated protein of 19 kDa, ... Authors: He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J. Deposit date: 2022-05-06 Release date: 2022-07-13 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase. Nature, 608, 2022
8KG8	Yeast replisome in state II Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... Authors: Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. Deposit date: 2023-08-17 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (4.23 Å) Cite: Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
8D0K	Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template - PRIM2C advanced PIC Descriptor: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... Authors: He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C. Deposit date: 2022-05-26 Release date: 2022-06-22 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (4.27 Å) Cite: Structures of the human CST-Pol alpha-primase complex bound to telomere templates. Nature, 608, 2022
6S1M	Human polymerase delta holoenzyme Conformer 1 Descriptor: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ... Authors: Lancey, C, Hamdan, S.M, De Biasio, A. Deposit date: 2019-06-19 Release date: 2019-12-25 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (4.27 Å) Cite: Structure of the processive human Pol delta holoenzyme. Nat Commun, 11, 2020
8G9O	Complete DNA elongation subcomplex of Xenopus laevis DNA polymerase alpha-primase Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA primase large subunit, ... Authors: Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. Deposit date: 2023-02-21 Release date: 2023-04-12 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 31, 2024
7UY8	Tetrahymena Polymerase alpha-Primase Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... Authors: He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J. Deposit date: 2022-05-06 Release date: 2022-07-13 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase. Nature, 608, 2022
8KG9	Yeast replisome in state III Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... Authors: Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. Deposit date: 2023-08-17 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (4.52 Å) Cite: Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
8FOH	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the RNA synthesis state Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... Authors: Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. Deposit date: 2022-12-30 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
7U5C	Cryo-EM structure of human CST bound to DNA polymerase alpha-primase in a recruitment state Descriptor: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... Authors: Cai, S.W, Zinder, J.C, Svetlov, V, Bush, M.W, Nudler, E, Walz, T, de Lange, T. Deposit date: 2022-03-02 Release date: 2022-05-18 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Cryo-EM structure of the human CST-Pol alpha /primase complex in a recruitment state. Nat.Struct.Mol.Biol., 29, 2022
8B9C	S. cerevisiae pol alpha - replisome complex Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... Authors: Jones, M.L, Yeeles, J.T.P. Deposit date: 2022-10-05 Release date: 2023-08-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
8FOJ	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the post RNA handoff state Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... Authors: Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. Deposit date: 2022-12-30 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
6S1N	Human polymerase delta holoenzyme Conformer 2 Descriptor: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ... Authors: Lancey, C, Hamdan, S.M, De Biasio, A. Deposit date: 2019-06-19 Release date: 2019-12-25 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (4.86 Å) Cite: Structure of the processive human Pol delta holoenzyme. Nat Commun, 11, 2020
8FOE	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex bound to a template DNA Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... Authors: Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. Deposit date: 2022-12-30 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (5.6 Å) Cite: Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
6S2F	Cryo-EM structure of Ctf18-1-8 in complex with the catalytic domain of DNA polymerase epsilon (Class 2) Descriptor: Chromosome transmission fidelity protein 18, Chromosome transmission fidelity protein 8, DNA polymerase epsilon catalytic subunit A, ... Authors: Grabarczyk, D.B, Song, B. Deposit date: 2019-06-20 Release date: 2020-07-08 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: Ctf18-RFC and DNA Pol ε form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication. Nucleic Acids Res., 48, 2020
6S1O	Human polymerase delta holoenzyme Conformer 3 Descriptor: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ... Authors: Lancey, C, Hamdan, S.M, De Biasio, A. Deposit date: 2019-06-19 Release date: 2019-12-25 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (8.1 Å) Cite: Structure of the processive human Pol delta holoenzyme. Nat Commun, 11, 2020
8V5N	Tetramer core subcomplex (conformation 2) of Xenopus laevis DNA polymerase alpha-primase Descriptor: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ... Authors: Mullins, E.A, Chazin, W.J, Eichman, B.F. Deposit date: 2023-11-30 Release date: 2023-12-20 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (8.56 Å) Cite: A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 31, 2024
8V5O	Tetramer core subcomplex (conformation 3) of Xenopus laevis DNA polymerase alpha-primase Descriptor: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ... Authors: Mullins, E.A, Chazin, W.J, Eichman, B.F. Deposit date: 2023-11-30 Release date: 2023-12-20 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (8.99 Å) Cite: A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 31, 2024
8V5M	Tetramer core subcomplex (conformation 1) of Xenopus laevis DNA polymerase alpha-primase Descriptor: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ... Authors: Mullins, E.A, Chazin, W.J, Eichman, B.F. Deposit date: 2023-11-30 Release date: 2023-12-20 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (9.22 Å) Cite: A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 31, 2024
8V6J	DNA elongation complex (configuration 2) of Xenopus laevis DNA polymerase alpha-primase Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, ... Authors: Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. Deposit date: 2023-12-01 Release date: 2023-12-20 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (11.11 Å) Cite: A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 31, 2024
8V6H	DNA initiation complex (configuration 2) of Xenopus laevis DNA polymerase alpha-primase Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, ... Authors: Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. Deposit date: 2023-12-01 Release date: 2023-12-20 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (11.11 Å) Cite: A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 31, 2024

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