9H0F
 
 | | SARS-CoV-2 Mpro in complex with a silicon-containing inhibitor | | Descriptor: | 3C-like proteinase nsp5, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Andrews-Clark, T.C, Laczi, D, Schoenbauer, S, Brewitz, L, Schofield, C.J, Walsh, M. | | Deposit date: | 2024-10-08 | | Release date: | 2025-06-11 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Silaproline-bearing nirmatrelvir derivatives are potent inhibitors of the SARS-CoV-2 main protease highlighting the value of silicon-derivatives in structure-activity-relationship studies.
Eur J Med Chem, 291, 2025
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