PDB: 238582 件ウェブページステータス検索Chemie searchBIRD

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3K3A	Crystal Structure of B/Perth Neuraminidase D197E mutant in complex with Oseltamivir 分子名称: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Oakley, A.J, McKimm-Breschkin, J.L. 登録日 2009-10-02 公開日 2010-09-01 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses. J.Med.Chem., 2010
3S5F	Crystal structure of human frataxin variant W155F 分子名称: Frataxin, mitochondrial, MAGNESIUM ION 著者 Tsai, C.-L, Bridwell-Rabb, J, Barondeau, D.P. 登録日 2011-05-23 公開日 2011-06-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Friedreich's Ataxia Variants I154F and W155R Diminish Frataxin-Based Activation of the Iron-Sulfur Cluster Assembly Complex. Biochemistry, 50, 2011
4UUT	Crystal structure of the Ultrabithorax protein 分子名称: CHLORIDE ION, HOMEOTIC PROTEIN ULTRABITHORAX, SULFATE ION 著者 Foos, N, Mate, M.J, Ortiz-Lombardia, M. 登録日 2014-07-31 公開日 2015-02-18 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A Flexible Extension of the Drosophila Ultrabithorax Homeodomain Defines a Novel Hox/Pbc Interaction Mode. Structure, 23, 2015
4UUO	Apo Trichomonas vaginalis malate dehydrogenase 分子名称: CYTOSOLIC MALATE DEHYDROGENASE 著者 Steindel, P.A, Chen, E.H, Theobald, D.L. 登録日 2014-07-29 公開日 2015-08-12 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.842 Å) 主引用文献 Gradual Neofunctionalization in the Convergent Evolution of Trichomonad Lactate and Malate Dehydrogenases. Protein Sci., 25, 2016
4UU2	Ferulic acid decarboxylase from Enterobacter sp., single mutant 分子名称: FERULIC ACID DECARBOXYLASE, GLYCINE, PHOSPHATE ION, ... 著者 Hromic, A, Pavkov-Keller, T, Steinkellner, G, Lyskowski, A, Wuensch, C, Gross, J, Fuchs, M, Fauland, K, Glueck, S.M, Faber, K, Gruber, K. 登録日 2014-07-24 公開日 2015-06-10 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Regioselective Enzymatic Beta-Carboxylation of Para-Hydroxy-Styrene Derivatives Catalyzed by Phenolic Acid Decarboxylases. Adv. Synth. Catal., 357, 2015
4UWK	Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors 分子名称: (2S)-1-[(5-chloro-2-thienyl)methyl]-8-[(3R,5R)-3,5-dimethylmorpholin-4-yl]-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one, GLYCEROL, PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3, ... 著者 Pasquier, B, El-Ahmad, Y, Filoche-Romme, B, Dureuil, C, Fassy, F, Abecassis, P.Y, Mathieu, M, Bertrand, T, Benard, T, Barriere, C, ElBatti, S, Letallec, J.P, Sonnefraud, V, Brollo, M, Delbarre, L, Loyau, V, Pilorge, F, Bertin, L, Richepin, P, Arigon, J, Labrosse, J.R, Clement, J, Durand, F, Combet, R, Perraut, P, Leroy, V, Gay, F, Lefrancois, D, Bretin, F, Marquette, J.P, Michot, N, Caron, A, Castell, C, Schio, L, McCort, G, Goulaouic, H, Garcia-Echeverria, C, Ronan, B. 登録日 2014-08-12 公開日 2014-11-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxo-Butyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors. J.Med.Chem., 58, 2015
3S74	The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase 分子名称: 1-benzothiophene-2-sulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Snyder, P.W, Heroux, A, Whitesides, G.W. 登録日 2011-05-26 公開日 2011-10-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase. Proc.Natl.Acad.Sci.USA, 108, 2011
4V17	Structure of a novel carbohydrate binding module from glycoside hydrolase family 5 glucanase from Ruminococcus flavefaciens FD-1 分子名称: CARBOHYDRATE BINDING MODULE 著者 Venditto, I, Centeno, M.S.J, Ferreira, L.M.A, Fontes, C.M.G.A, Najmudin, S. 登録日 2014-09-25 公開日 2016-01-20 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Complexity of the Ruminococcus Flavefaciens Cellulosome Reflects an Expansion in Glycan Recognition. Proc.Natl.Acad.Sci.USA, 113, 2016
4V0W	The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-669) 分子名称: MANGANESE (II) ION, PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15B, SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT 著者 Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J. 登録日 2014-09-18 公開日 2015-03-25 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases. Elife, 4, 2015
3SGV	Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1290 分子名称: 2-{[3-(3,4-dimethylphenoxy)phenyl]carbamoyl}-4-nitrobenzoic acid, Undecaprenyl pyrophosphate synthase 著者 Cao, R, Liu, Y.-L, Oldfield, E. 登録日 2011-06-15 公開日 2012-12-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Antibacterial drug leads targeting isoprenoid biosynthesis. Proc.Natl.Acad.Sci.USA, 110, 2013
4UWL	Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors 分子名称: (8S)-2-[(3R)-3-methylmorpholin-4-yl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one, PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3, SULFATE ION 著者 Pasquier, B, El-Ahmad, Y, Filoche-Romme, B, Dureuil, C, Fassy, F, Abecassis, P.Y, Mathieu, M, Bertrand, T, Benard, T, Barriere, C, ElBatti, S, Letallec, J.P, Sonnefraud, V, Brollo, M, Delbarre, L, Loyau, V, Pilorge, F, Bertin, L, Richepin, P, Arigon, J, Labrosse, J.R, Clement, J, Durand, F, Combet, R, Perraut, P, Leroy, V, Gay, F, Lefrancois, D, Bretin, F, Marquette, J.P, Michot, N, Caron, A, Castell, C, Schio, L, McCort, G, Goulaouic, H, Garcia-Echeverria, C, Ronan, B. 登録日 2014-08-12 公開日 2014-11-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxo-Butyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors. J.Med.Chem., 58, 2015
4UWH	Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors 分子名称: (8S)-9-[(2R)-2-hydroxy-2-phenylethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one, PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3, SODIUM ION 著者 Pasquier, B, El-Ahmad, Y, Filoche-Romme, B, Dureuil, C, Fassy, F, Abecassis, P.Y, Mathieu, M, Bertrand, T, Benard, T, Barriere, C, ElBatti, S, Letallec, J.P, Sonnefraud, V, Brollo, M, Delbarre, L, Loyau, V, Pilorge, F, Bertin, L, Richepin, P, Arigon, J, Labrosse, J.R, Clement, J, Durand, F, Combet, R, Perraut, P, Leroy, V, Gay, F, Lefrancois, D, Bretin, F, Marquette, J.P, Michot, N, Caron, A, Castell, C, Schio, L, McCort, G, Goulaouic, H, Garcia-Echeverria, C, Ronan, B. 登録日 2014-08-12 公開日 2014-11-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxo-Butyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors. J.Med.Chem., 58, 2015
4UYJ	Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation 分子名称: SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN, SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN, SRP RNA 著者 Bousset, L, Mary, C, Brooks, M.A, Scherrer, A, Strub, K, Cusack, S. 登録日 2014-09-01 公開日 2014-11-05 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Crystal Structure of a Signal Recognition Particle Alu Domain in the Elongation Arrest Conformation. RNA, 20, 2014
4UTI	XenA - oxidized - Y183F variant in complex with coumarin 分子名称: COUMARIN, FLAVIN MONONUCLEOTIDE, NADH:flavin oxidoreductase, ... 著者 Werther, T, Dobbek, H. 登録日 2014-07-21 公開日 2015-08-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.099 Å) 主引用文献 Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase Nat Commun, 8, 2017
4UYI	Crystal structure of the BTB domain of human SLX4 (BTBD12) 分子名称: STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4 著者 Pinkas, D.M, Sanvitale, C.E, Strain-Damerell, C, Fairhead, M, Wang, D, Tallant, C, Cooper, C.D.O, Sorrell, F.J, Kopec, J, Chaikuad, A, Fitzpatrick, F, Pike, A.C.W, Hozjan, V, Ying, Z, Roos, A.K, Savitsky, P, Bradley, A, Nowak, R, Filippakopoulos, P, Krojer, T, Burgess-Brown, N.A, Marsden, B.D, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. 登録日 2014-09-01 公開日 2014-10-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Crystal Structure of the Btb Domain of Human Slx4 (Btbd12) To be Published
4UY3	Cytoplasmic domain of bacterial cell division protein ezra 分子名称: SEPTATION RING FORMATION REGULATOR EZRA 著者 Cleverley, R.M, Barrett, J.R, Basle, A, Khai-Bui, N, Hewitt, L, Solovyova, A, Xu, Z, Daniela, R.A, Dixon, N.E, Harry, E.J, Oakley, A.J, Vollmer, W, Lewis, R.J. 登録日 2014-08-28 公開日 2014-10-22 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure and Function of a Spectrin-Like Regulator of Bacterial Cytokinesis. Nat.Commun., 5, 2014
3K7L	Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Atragin, CALCIUM ION, ... 著者 Guan, H.H, Wu, W.G, Chen, C.J. 登録日 2009-10-13 公開日 2010-03-02 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins J.Struct.Biol., 169, 2010
4UXH	Leishmania major Thymidine Kinase in complex with AP5dT 分子名称: P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, THYMIDINE KINASE, ZINC ION 著者 Timm, J, Bosch-Navarrete, C, Recio, E, Nettleship, J.E, Rada, H, Gonzalez-Pacanowska, D, Wilson, K.S. 登録日 2014-08-22 公開日 2015-05-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and Kinetic Characterization of Thymidine Kinase from Leishmania Major. Plos Negl Trop Dis, 9, 2015
3S8D	Crystal Structure of RipA from Yersinia pestis 分子名称: Coenzyme A transferase 著者 Torres, R, Goulding, C.W. 登録日 2011-05-27 公開日 2012-01-18 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis. Plos One, 6, 2011
4UZH	SAR156497 an exquisitely selective inhibitor of Aurora kinases 分子名称: (4S)-4-(2-fluorophenyl)-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b][1,7]naphthyridin-5-one, AURORA 2 KINASE DOMAIN 著者 Pouzieux, S, Maignan, S, Crenne, J.Y. 登録日 2014-09-05 公開日 2014-11-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Sar156497 an Exquisitely Selective Inhibitor of Aurora Kinases. J.Med.Chem., 58, 2015
4UZZ	Crystal structure of the TtIFT52-46 complex 分子名称: INTRAFLAGELLAR TRANSPORT COMPLEX B PROTEIN 46 CARBOXY-TERMINAL PROTEIN, INTRAFLAGELLAR TRANSPORTER-LIKE PROTEIN 著者 Braeuer, P, Taschner, M, Lorentzen, E. 登録日 2014-09-09 公開日 2014-11-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.318 Å) 主引用文献 Crystal Structures of Ift70/52 and Ift52/46 Provide Insight Into Intraflagellar Transport B Core Complex Assembly. J.Cell Biol., 207, 2014
3SIY	Crystal structure of a DUF1989 family protein (TM1040_0329) from SILICIBACTER SP. TM1040 at 1.35 A resolution 分子名称: CHLORIDE ION, DUF1989 family protein, MAGNESIUM ION, ... 著者 Joint Center for Structural Genomics (JCSG) 登録日 2011-06-20 公開日 2011-07-13 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Crystal structure of a DUF1989 family protein (TM1040_0329) from SILICIBACTER SP. TM1040 at 1.35 A resolution To be published
4V36	The structure of L-PGS from Bacillus licheniformis 分子名称: 2,6-DIAMINO-HEXANOIC ACID AMIDE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, LYSYL-TRNA-DEPENDENT L-YSYL-PHOSPHATIDYLGYCEROL SYNTHASE 著者 Krausze, J, Hebecker, S, Heinz, D.W, Moser, J. 登録日 2014-10-16 公開日 2015-08-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structures of Two Bacterial Resistance Factors Mediating tRNA-Dependent Aminoacylation of Phosphatidylglycerol with Lysine or Alanine. Proc.Natl.Acad.Sci.USA, 112, 2015
4V03	MinD cell division protein, Aquifex aeolicus 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, SITE-DETERMINING PROTEIN 著者 Trambaiolo, D, Lowe, J. 登録日 2014-09-10 公開日 2015-01-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mincd Cell Division Proteins Form Alternating Copolymeric Cytomotive Filaments. Nat.Commun., 5, 2014
3S9W	Crystal structure of Staphylococcal nuclease variant Delta+PHS M98G bound to Ca2+ and thymidine-5',3'-diphosphate at cryogenic temperature 分子名称: CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease 著者 Doctrow, B.M, Schlessman, J.L, Garcia-Moreno E, B, Heroux, A. 登録日 2011-06-02 公開日 2011-06-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Staphylococcal nuclease variant Delta+PHS M98G bound to Ca2+ and thymidine-5',3'-diphosphate at cryogenic temperature To be Published

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