7ER6
 
 | | Crystal structure of human Biliverdin IX-beta reductase B | | 分子名称: | Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION | | 著者 | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | 登録日 | 2021-05-06 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ER7
 | | Crystal structure of hyman Biliverdin IX-beta reductase B with Tamibarotene (A80) | | 分子名称: | 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | 登録日 | 2021-05-06 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ERC
 | | Crystal structure of human Biliverdin IX-beta reductase B with Deferasirox (ICL) | | 分子名称: | 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | 登録日 | 2021-05-06 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ERD
 | | Crystal structure of human Biliverdin IX-beta reductase B with Flunixin Meglumin (FMG) | | 分子名称: | 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | 登録日 | 2021-05-06 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ER8
 | | Crystal structure of human Biliverdin IX-beta reductase B with Sulfasalazine (SAS) | | 分子名称: | 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | 登録日 | 2021-05-06 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ERB
 | | Crystal structure of human Biliverdin IX-beta reductase B with Ataluren (PTC) | | 分子名称: | 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | 登録日 | 2021-05-06 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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7ERA
 | | Crystal structure of human Biliverdin IX-beta reductase B with Olsalazine Sodium (OSS) | | 分子名称: | 5-[(E)-(3-carboxy-4-oxidanyl-phenyl)diazenyl]-2-oxidanyl-benzoic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | 登録日 | 2021-05-06 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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5INJ
 | | Crystal Structure of Prenyltransferase PriB Ternary Complex with L-Tryptophan and Dimethylallyl thiolodiphosphate (DMSPP) | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYLALLYL S-THIOLODIPHOSPHATE, Prenyltransferase, ... | | 著者 | Cao, H, Elshahawi, S, Benach, J, Wasserman, S.R, Morisco, L.L, Koss, J.W, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2016-03-07 | | 公開日 | 2016-05-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structure and specificity of a permissive bacterial C-prenyltransferase.
Nat. Chem. Biol., 13, 2017
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1EZU
 | | ECOTIN Y69F, D70P BOUND TO D102N TRYPSIN | | 分子名称: | CALCIUM ION, ECOTIN, TRYPSIN II, ... | | 著者 | Gillmor, S.A, Takeuchi, T, Yang, S.Q, Craik, C.S, Fletterick, R.J. | | 登録日 | 2000-05-11 | | 公開日 | 2000-06-23 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases.
J.Mol.Biol., 299, 2000
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1EZS
 | | CRYSTAL STRUCTURE OF ECOTIN MUTANT M84R, W67A, G68A, Y69A, D70A BOUND TO RAT ANIONIC TRYPSIN II | | 分子名称: | CALCIUM ION, ECOTIN, TRYPSIN II, ... | | 著者 | Gillmor, S.A, Takeuchi, T, Yang, S.Q, Craik, C.S, Fletterick, R.J. | | 登録日 | 2000-05-11 | | 公開日 | 2000-06-23 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases.
J.Mol.Biol., 299, 2000
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4NLJ
 | | Crystal structure of sheep beta-lactoglobulin (space group P1) | | 分子名称: | Beta-lactoglobulin-1/B, SULFATE ION | | 著者 | Loch, J.I, Molenda, M, Kopec, M, Swiatek, S, Lewinski, K. | | 登録日 | 2013-11-14 | | 公開日 | 2014-03-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structure of two crystal forms of sheep beta-lactoglobulin with EF-loop in closed conformation
Biopolymers, 101, 2014
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2AGH
 | | Structural basis for cooperative transcription factor binding to the CBP coactivator | | 分子名称: | Crebbp protein, Myb proto-oncogene protein, Zinc finger protein HRX | | 著者 | De Guzman, R.N, Goto, N.K, Dyson, H.J, Wright, P.E. | | 登録日 | 2005-07-26 | | 公開日 | 2005-11-22 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Basis for Cooperative Transcription Factor Binding to the CBP Coactivator
J.Mol.Biol., 355, 2006
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3UF1
 | | Crystal Structure of Vimentin (fragment 144-251) from Homo sapiens, Northeast Structural Genomics Consortium Target HR4796B | | 分子名称: | Vimentin | | 著者 | Kuzin, A, Abashidze, M, Vorobiev, S.M, Patel, P, Xiao, R, Ciccosanti, C, Shastry, R, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2011-10-31 | | 公開日 | 2011-11-30 | | 最終更新日 | 2013-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | The structure of vimentin linker 1 and rod 1B domains characterized by site-directed spin-labeling electron paramagnetic resonance (SDSL-EPR) and X-ray crystallography.
J.Biol.Chem., 287, 2012
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1CTS
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6ZKJ
 | | Complex I with NADH, open3 | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | | 著者 | Kampjut, D, Sazanov, L.A. | | 登録日 | 2020-06-30 | | 公開日 | 2020-10-07 | | 最終更新日 | 2020-11-11 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | The coupling mechanism of mammalian respiratory complex I.
Science, 370, 2020
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6ZK9
 | | Peripheral domain of open complex I during turnover | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | | 著者 | Kampjut, D, Sazanov, L.A. | | 登録日 | 2020-06-30 | | 公開日 | 2020-10-07 | | 最終更新日 | 2020-11-11 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | The coupling mechanism of mammalian respiratory complex I.
Science, 370, 2020
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6ZKN
 | | Complex I inhibited by rotenone, open3 | | 分子名称: | (2R,6aS,12aS)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrofuro[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-6(6aH)-one, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ... | | 著者 | Kampjut, D, Sazanov, L.A. | | 登録日 | 2020-06-30 | | 公開日 | 2020-10-07 | | 最終更新日 | 2020-11-11 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | The coupling mechanism of mammalian respiratory complex I.
Science, 370, 2020
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4HJV
 | | Crystal structure of E. coli MltE with bound bulgecin and murodipeptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-N-acetyl-beta-muramic acid, 4-O-(4-O-SULFONYL-N-ACETYLGLUCOSAMININYL)-5-METHYLHYDROXY-L-PROLINE-TAURINE, Endo-type membrane-bound lytic murein transglycosylase A, ... | | 著者 | Fibriansah, G, Gliubich, F.I, Thunnissen, A.-M.W.H. | | 登録日 | 2012-10-14 | | 公開日 | 2012-10-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | On the Mechanism of Peptidoglycan Binding and Cleavage by the endo-Specific Lytic Transglycosylase MltE from Escherichia coli.
Biochemistry, 51, 2012
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1YEB
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6ZKC
 | | Complex I during turnover, closed | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | | 著者 | Kampjut, D, Sazanov, L.A. | | 登録日 | 2020-06-30 | | 公開日 | 2020-10-07 | | 最終更新日 | 2020-11-11 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | The coupling mechanism of mammalian respiratory complex I.
Science, 370, 2020
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6ZKR
 | | Native complex I, open3 | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE MONOPHOSPHATE, ... | | 著者 | Kampjut, D, Sazanov, L.A. | | 登録日 | 2020-06-30 | | 公開日 | 2020-10-07 | | 最終更新日 | 2020-11-11 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | The coupling mechanism of mammalian respiratory complex I.
Science, 370, 2020
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5WB5
 | | Leishmania IF4E-1 bound to Leishmania 4E-IP1 | | 分子名称: | DI(HYDROXYETHYL)ETHER, Putative eukaryotic translation initiation factor eIF-4E, Uncharacterized protein | | 著者 | Leger-Abraham, M, Meleppattu, S, Arthanari, H, Zinoviev, A, Boeszoermenyi, A, Wagner, G, Shapira, M. | | 登録日 | 2017-06-27 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major.
Nucleic Acids Res., 46, 2018
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5WEM
 | | GluA2 bound to GSG1L in digitonin, state 1 | | 分子名称: | Chimera of Glutamate receptor 2,Germ cell-specific gene 1-like protein | | 著者 | Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. | | 登録日 | 2017-07-10 | | 公開日 | 2017-08-02 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | | 主引用文献 | Channel opening and gating mechanism in AMPA-subtype glutamate receptors.
Nature, 549, 2017
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5S9S
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5S9V
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