PDB: 1334 件ウェブページステータス検索Chemie searchBIRD

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1CCS	STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Ippolito, J.A, Christianson, D.W. 登録日 1994-12-09 公開日 1995-02-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity. Proc.Natl.Acad.Sci.USA, 92, 1995
1BN4	CARBONIC ANHYDRASE II INHIBITOR 分子名称: CARBONIC ANHYDRASE, MERCURY (II) ION, N-[(4-METHOXYPHENYL)METHYL]2,5-THIOPHENEDESULFONAMIDE, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-31 公開日 1999-05-18 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BN1	CARBONIC ANHYDRASE II INHIBITOR 分子名称: CARBONIC ANHYDRASE, MERCURY (II) ION, THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE), ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-31 公開日 1999-05-18 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNQ	CARBONIC ANHYDRASE II INHIBITOR 分子名称: (R)-4-ETHYLAMINO-3,4-DIHYDRO-2-(2-METHOYLETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-30 公開日 1999-06-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNV	CARBONIC ANHYDRASE II INHIBITOR 分子名称: (S)-3,4-DIHYDRO-2-(3-METHOXYPHENYL)-4-METHYLAMINO-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-30 公開日 1999-02-16 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1CVD	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Ippolito, J.A, Christianson, D.W. 登録日 1994-06-21 公開日 1994-12-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
1CVH	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Ippolito, J.A, Christianson, D.W. 登録日 1994-11-16 公開日 1995-02-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
1CNW	SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS 分子名称: AMINOMETHYLENECARBONYLAMINODI(ETHYLOXY)ETHYLAMINOCARBONYLBENZENESULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... 著者 Boriack, P.A, Christianson, D.W. 登録日 1995-07-21 公開日 1995-11-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants. J.Med.Chem., 38, 1995
1CNB	COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES 分子名称: BETA-MERCAPTOETHANOL, CARBONIC ANHYDRASE II 著者 Ippolito, J.A, Christianson, D.W. 登録日 1994-06-13 公開日 1994-10-15 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
1CNJ	X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE 分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION 著者 Lesburg, C.A, Christianson, D.W. 登録日 1995-04-03 公開日 1995-07-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site J.Am.Chem.Soc., 117, 1995
1CIM	THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS 分子名称: (4S-TRANS)-4-(AMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO (2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, CARBONIC ANHYDRASE II, METHYL MERCURY ION, ... 著者 Smith, G.M, Alexander, R.S, Christianson, D.W, Mckeever, B.M, Ponticello, G.S, Springer, J.P, Randall, W.C, Baldwin, J.J, Habecker, C.N. 登録日 1993-10-20 公開日 1994-01-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors. Protein Sci., 3, 1994
1CVE	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Ippolito, J.A, Christianson, D.W. 登録日 1994-06-21 公開日 1994-11-30 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
1BIC	CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3- 分子名称: BICARBONATE ION, CARBONIC ANHYDRASE II, METHYL MERCURY ION, ... 著者 Xue, Y, Vidgren, J, Svensson, L.A, Liljas, A, Jonsson, B.-H, Lindskog, S. 登録日 1992-09-01 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystallographic analysis of Thr-200-->His human carbonic anhydrase II and its complex with the substrate, HCO3-. Proteins, 15, 1993
1CNC	COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Ippolito, J.A, Christianson, D.W. 登録日 1994-06-13 公開日 1994-10-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
1CVB	STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION 著者 Ippolito, J.A, Christianson, D.W. 登録日 1993-02-04 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II. J.Biol.Chem., 268, 1993
1CNI	X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE 分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION 著者 Lesburg, C.A, Christianson, D.W. 登録日 1995-04-03 公開日 1995-07-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site J.Am.Chem.Soc., 117, 1995
1CVF	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE 分子名称: CARBONIC ANHYDRASE II 著者 Ippolito, J.A, Christianson, D.W. 登録日 1994-06-21 公開日 1994-11-30 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural consequences of redesigning a protein-zinc binding site. Biochemistry, 33, 1994
4N0X	Room temperature crystal structure of human carbonic anhydrase II in complex with thiophene-2-sulfonamide 分子名称: Carbonic anhydrase 2, ZINC ION, thiophene-2-sulfonamide 著者 Fisher, S.Z, Williams, R.F. 登録日 2013-10-02 公開日 2014-01-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Room temperature crystal structure of human carbonic anhydrase II in complex with thiophene-2-sulfonamide To be Published
4MO8	The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide 分子名称: Carbonic anhydrase 2, N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide, ZINC ION 著者 Alterio, V, De Simone, G. 登録日 2013-09-11 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Hypoxia-Targeting Carbonic Anhydrase IX Inhibitors by a New Series of Nitroimidazole-Sulfonamides/Sulfamides/Sulfamates. J.Med.Chem., 56, 2013
4Q08	Crystal structure of chimeric carbonic anhydrase XII with inhibitor 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)sulfanyl]benzenesulfonamide, BICINE, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2014-04-01 公開日 2015-01-28 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.07 Å) 主引用文献 Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. J.Med.Chem., 57, 2014
4PZH	Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide 分子名称: 1,2-ETHANEDIOL, 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2014-03-31 公開日 2015-01-28 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.06 Å) 主引用文献 Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. J.Med.Chem., 57, 2014
4Q0L	Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with inhibitor 分子名称: 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, Carbonic anhydrase 12, ZINC ION 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2014-04-02 公開日 2015-01-28 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. J.Med.Chem., 57, 2014
4Q7W	Crystal structure of 1-hydroxy-6-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II 分子名称: 1-hydroxy-6-methylpyridine-2(1H)-thione, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Martin, D.P, Cohen, S.M. 登録日 2014-04-25 公開日 2015-03-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Exploring the influence of the protein environment on metal-binding pharmacophores. J.Med.Chem., 57, 2014
4MTY	Structure at 1A resolution of a helical aromatic foldamer-protein complex. 分子名称: 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase 2, GLYCEROL, ... 著者 Ogayone, T, Buratto, J, Langlois D'Estaintot, B, Stupfel, M, Granier, T, Gallois, B, Huc, Y. 登録日 2013-09-20 公開日 2013-12-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 a resolution. Angew.Chem.Int.Ed.Engl., 53, 2014
4PYX	Crystal structure of human carbonic anhydrase isozyme II with inhibitor 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)sulfanyl]benzenesulfonamide, Carbonic anhydrase 2, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2014-03-28 公開日 2015-01-28 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. J.Med.Chem., 57, 2014

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