8XFO
 
 | | Cryo-EM structure of integrin ITGAV, ITGB3 and CYCLO (RGDFK) complex, conformation 2 | | 分子名称: | 2-[(2~{R},5~{R},8~{S},11~{S})-8-(4-azanylbutyl)-11-(3-carbamimidamidopropyl)-3,6,9,12,15-pentakis(oxidanylidene)-5-(phenylmethyl)-1,4,7,10,13-pentazacyclopentadec-2-yl]ethanoic acid, Integrin alpha-V, Integrin beta-3 | | 著者 | Xi, Z. | | 登録日 | 2023-12-14 | | 公開日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cryo-EM structure of integrin ITGAV, ITGB3 and CYCLO (RGDFK) complex, conformation 2
To Be Published
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9CKV
 | | Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Werther, R, Nguyen, A, Estrada Alamo, K.A, Wang, X, Campbell, M.G. | | 登録日 | 2024-07-09 | | 公開日 | 2024-07-17 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | De Novo Design of Integrin alpha 5 beta 1 Modulating Proteins to Enhance Biomaterial Properties.
Adv Mater, 2025
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9DEQ
 | | Cryo-EM structures of full-length integrin alphaIIbbeta3 in native lipids complexed with modified tirofiban | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. | | 登録日 | 2024-08-29 | | 公開日 | 2024-10-16 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Platelet integrin alpha IIb beta 3 plays a key role in a venous thrombogenesis mouse model.
Nat Commun, 15, 2024
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9DER
 | | Cryo-EM Structures of Full-Length Integrin alphaIIbbeta3 in Native Lipids Complexed with Tirofiban | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-IIb, ... | | 著者 | Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. | | 登録日 | 2024-08-29 | | 公開日 | 2024-10-16 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Platelet integrin alpha IIb beta 3 plays a key role in a venous thrombogenesis mouse model.
Nat Commun, 15, 2024
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9DAX
 | | The structure of AlphaIIbbeta3 in apo state | | 分子名称: | CALCIUM ION, Integrin alpha-IIb, Integrin beta-3, ... | | 著者 | Walz, T, Coller, B.S, Wang, J.L, Buitrago, L, Wang, L, Li, J.H. | | 登録日 | 2024-08-22 | | 公開日 | 2025-04-09 | | 最終更新日 | 2025-05-14 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | An alpha IIb beta 3 Ligand-Mimetic Murine Monoclonal Antibody That Produces Platelet Activation by Engaging the Fc gamma IIa Receptor.
Blood Adv, 2025
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9DAO
 | | AlphaIIbbeta3 in fully-extended conformation in complex with R6H8 Fab | | 分子名称: | CALCIUM ION, Integrin alpha-IIb, Integrin beta-3, ... | | 著者 | Walz, T, Coller, B.S, Wang, J.L, Buitrago, L, Wang, L, Li, J.H. | | 登録日 | 2024-08-22 | | 公開日 | 2025-04-09 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | An alpha IIb beta 3 Ligand-Mimetic Murine Monoclonal Antibody That Produces Platelet Activation by Engaging the Fc gamma IIa Receptor.
Blood Adv, 2025
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9CZ7
 | | Crystal structure of integrin avb6 headpiece in complex with compound 12 | | 分子名称: | (2S)-phenyl{(3S)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid, 17E6 Fab heavy chain, 17E6 Fab light chain, ... | | 著者 | Monroy, M.F, Qiao, Q, Lin, F.Y. | | 登録日 | 2024-08-04 | | 公開日 | 2024-11-13 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin alpha v beta 6 Inhibitor for Fibrosis.
J.Med.Chem., 67, 2024
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9CZF
 | | Crystal structure of integrin avb6 headpiece in complex with compound MORF-627 | | 分子名称: | (2S)-{5-fluoro-2-[(6S)-5-oxaspiro[2.5]octan-6-yl]phenyl}{(3R)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid, 17E6 Fab heavy chain, 17E6 Fab light chain, ... | | 著者 | Monroy, M.F, Qiao, Q, Lin, F.Y. | | 登録日 | 2024-08-05 | | 公開日 | 2024-11-13 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin alpha v beta 6 Inhibitor for Fibrosis.
J.Med.Chem., 67, 2024
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9CZD
 | | Crystal structure of integrin avb6 headpiece in complex with compound 30 | | 分子名称: | (2S)-{5-fluoro-2-[(2S)-oxan-2-yl]phenyl}{(3R)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid, 17E6 Fab heavy chain, 17E6 Fab light chain, ... | | 著者 | Monroy, M.F, Qiao, Q, Lin, F.Y. | | 登録日 | 2024-08-05 | | 公開日 | 2024-11-13 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin alpha v beta 6 Inhibitor for Fibrosis.
J.Med.Chem., 67, 2024
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9CZA
 | | Crystal structure of integrin avb6 headpiece in complex with compound 18 | | 分子名称: | (2S)-(2-cyclopropylphenyl){(3R)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid, 17E6 Fab heavy chain, 17E6 Fab light chain, ... | | 著者 | Monroy, M.F, Qiao, Q, Lin, F.Y. | | 登録日 | 2024-08-05 | | 公開日 | 2024-11-13 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin alpha v beta 6 Inhibitor for Fibrosis.
J.Med.Chem., 67, 2024
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9DIA
 | | Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin candidate 2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Werther, R, Nguyen, A, Estrada Alamo, K.A, Wang, X, Campbell, M.G. | | 登録日 | 2024-09-05 | | 公開日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | De Novo Design of Integrin alpha 5 beta 1 Modulating Proteins to Enhance Biomaterial Properties.
Adv Mater, 2025
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9EF2
 | | Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin candidate 2, open conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Werther, R, Nguyen, A, Estrada Alamo, K.A, Wang, X, Campbell, M.G. | | 登録日 | 2024-11-19 | | 公開日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | De Novo Design of Integrin alpha 5 beta 1 Modulating Proteins to Enhance Biomaterial Properties.
Adv Mater, 2025
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9B9J
 | | Integrin alpha-5 beta-1 in complex with BIIG2 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BIIG2 Fab Heavy Chain, ... | | 著者 | Nguyen, A, Azumaya, C.M, Campbell, M.G. | | 登録日 | 2024-04-02 | | 公開日 | 2025-02-05 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural and functional characterization of integrin alpha 5-targeting antibodies for anti-angiogenic therapy.
Biorxiv, 2025
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9B9K
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