8V9Z
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8V9Y
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8V9X
| X-ray crystal structure of JGFN4 complex with fentanyl | 分子名称: | 1,2-ETHANEDIOL, JGFN4, N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide | 著者 | Moller, N, Shi, K, Aihara, H. | 登録日 | 2023-12-10 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Identification and biophysical characterization of a novel domain-swapped camelid antibody specific for fentanyl. J.Biol.Chem., 300, 2024
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8V9W
| X-ray crystal structure of JGFN4 complexed with fentanyl | 分子名称: | 1,2-ETHANEDIOL, JGFN4, N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide | 著者 | Moller, N, Shi, K, Aihara, H. | 登録日 | 2023-12-10 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Identification and biophysical characterization of a novel domain-swapped camelid antibody specific for fentanyl. J.Biol.Chem., 300, 2024
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8V9U
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8V9Q
| Crystal structure of mGalNAc-T1 in complex with the mucin glycopeptide Muc5AC-13, Mn2+, and UDP. | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Samara, N.L, Collette, A.M. | 登録日 | 2023-12-08 | 公開日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | An unusual dual sugar-binding lectin domain controls the substrate specificity of a mucin-type O-glycosyltransferase. Sci Adv, 10, 2024
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8V9P
| Proteus vulgaris tryptophan indole-lyase complexed with (3S)-dioxindolyl-L-alanine | 分子名称: | (2~{E})-2-[(~{Z})-[2-methyl-3-oxidanyl-5-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]-1~{H}-pyridin-4-ylidene]methyl]imino-3-[(3~{S})-3-oxidanyl-2-oxidanylidene-1~{H}-indol-3-yl]propanoic acid, DIMETHYL SULFOXIDE, POTASSIUM ION, ... | 著者 | Phillips, R.S. | 登録日 | 2023-12-08 | 公開日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Proteus vulgaris tryptophan indole-lyase complexed with L-ethionine To Be Published
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8V9O
| Imaging scaffold engineered to bind the therapeutic protein target BARD1 | 分子名称: | CALCIUM ION, Tetrahedral Nanocage Cage Component Fused to Anti-BARD1 Darpin, Tetrahedral Nanocage Cage, ... | 著者 | Agdanowski, M.P, Castells-Graells, R, Sawaya, M.R, Yeates, T.O, Arbing, M.A. | 登録日 | 2023-12-08 | 公開日 | 2024-05-15 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (3.81 Å) | 主引用文献 | X-ray crystal structure of a designed rigidified imaging scaffold in the ligand-free conformation. Acta Crystallogr.,Sect.F, 80, 2024
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8V9M
| Human Ornithine Aminotransferase cocrystallized with its inhibitor, (R)-3-amino-5,5-difluorocyclohex-1-ene-1-carboxylic acid. | 分子名称: | 3-fluoro-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]benzoic acid, GLYCEROL, Ornithine aminotransferase, ... | 著者 | Vargas, A.L, Devitt, A, Kaley, N, Silverman, R, Liu, D. | 登録日 | 2023-12-08 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. Acs Chem.Biol., 19, 2024
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8V9B
| Lipoprotein(a) Kringle IV domain 7 - Lp(a) KIV7 in complex with LY3441732 | 分子名称: | (2S,2'S)-3,3'-[carbonylbis(azanediyl-3,1-phenylene)]bis{2-[(3R)-pyrrolidin-1-ium-3-yl]propanoate}, Apolipoprotein(a), MAGNESIUM ION, ... | 著者 | Hendle, J, Weichert, K, Sauder, J.M. | 登録日 | 2023-12-07 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | Discovery of potent small-molecule inhibitors of lipoprotein(a) formation. Nature, 629, 2024
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8V9A
| GII.NA1 Loreto 1257 norovirus protruding domain | 分子名称: | 1,2-ETHANEDIOL, Capsid protein VP1 | 著者 | Kher, G, Kim, I, Pancera, M, Hansman, G. | 登録日 | 2023-12-07 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Development of a broad-spectrum therapeutic Fc-nanobody for human noroviruses. J.Virol., 98, 2024
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8V99
| GII.26 Leon 4509 norovirus protruding domain | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Capsid protein VP1, ... | 著者 | Kher, G, Reese, T, Pancera, M, Hansman, G. | 登録日 | 2023-12-07 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Development of a broad-spectrum therapeutic Fc-nanobody for human noroviruses. J.Virol., 98, 2024
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8V98
| GII.24 Loreto 1972 norovirus protruding domain | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Capsid protein VP1 | 著者 | Kher, G, Prewitt, A, Pancera, M, Hansman, G. | 登録日 | 2023-12-07 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Development of a broad-spectrum therapeutic Fc-nanobody for human noroviruses. J.Virol., 98, 2024
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8V97
| GII.17 CS-E1 norovirus protruding domain | 分子名称: | 1,2-ETHANEDIOL, Capsid protein VP1, DI(HYDROXYETHYL)ETHER | 著者 | Kher, G, Prewitt, A, Pancera, M, Hansman, G. | 登録日 | 2023-12-07 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Development of a broad-spectrum therapeutic Fc-nanobody for human noroviruses. J.Virol., 98, 2024
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8V96
| GII.14 M7 norovirus protruding domain | 分子名称: | 1,2-ETHANEDIOL, Capsid protein VP1 | 著者 | Kher, G, Prewitt, A, Pancera, M, Hansman, G. | 登録日 | 2023-12-07 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | Development of a broad-spectrum therapeutic Fc-nanobody for human noroviruses. J.Virol., 98, 2024
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8V95
| GII.8 Amsterdam norovirus protruding domain | 分子名称: | 1,2-ETHANEDIOL, Capsid protein (Fragment) | 著者 | Kher, G, Prewitt, A, Pancera, M, Hansman, G. | 登録日 | 2023-12-07 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Development of a broad-spectrum therapeutic Fc-nanobody for human noroviruses. J.Virol., 98, 2024
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8V8Z
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8V8Y
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8V8X
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8V8W
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8V8V
| PI3Ka H1047R co-crystal structure with inhibitor in cryptic pocket near H1047R (compound 7). | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, 2-[[(1~{R})-1-(7-methyl-4-oxidanylidene-2-piperidin-1-yl-3~{H}-pyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoic acid, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... | 著者 | Gunn, R.J, Lawson, J.D. | 登録日 | 2023-12-06 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3K alpha Mutant Protein. J.Med.Chem., 67, 2024
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8V8U
| PI3Ka H1047R co-crystal structure with inhibitor in cryptic pocket near H1047R (compound 12). | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, (3S)-9-[(1R)-1-(2-carboxyanilino)ethyl]-3-cyano-7-methyl-4-oxo-2-(piperidin-1-yl)-3,4-dihydropyrido[1,2-a]pyrimidin-5-ium, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... | 著者 | Gunn, R.J, Lawson, J.D. | 登録日 | 2023-12-06 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | 主引用文献 | Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3K alpha Mutant Protein. J.Med.Chem., 67, 2024
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8V8O
| Switchgrass Chalcone Isomerase-Like Protein | 分子名称: | Chalcone-flavonone isomerase family protein | 著者 | Lewis, J.A, Kang, C. | 登録日 | 2023-12-05 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | 主引用文献 | Structural and Interactional Analysis of the Flavonoid Pathway Proteins: Chalcone Synthase, Chalcone Isomerase and Chalcone Isomerase-like Protein. Int J Mol Sci, 25, 2024
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8V8N
| Switchgrass Chalcone Synthase C170S | 分子名称: | Chalcone synthase, GLYCEROL | 著者 | Lewis, J.A, Kang, C. | 登録日 | 2023-12-05 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Structural and Interactional Analysis of the Flavonoid Pathway Proteins: Chalcone Synthase, Chalcone Isomerase and Chalcone Isomerase-like Protein. Int J Mol Sci, 25, 2024
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8V8M
| Switchgrass Chalcone Synthase | 分子名称: | COENZYME A, Chalcone synthase, NARINGENIN | 著者 | Lewis, J.A, Kang, C. | 登録日 | 2023-12-05 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Structural and Interactional Analysis of the Flavonoid Pathway Proteins: Chalcone Synthase, Chalcone Isomerase and Chalcone Isomerase-like Protein. Int J Mol Sci, 25, 2024
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