8ORD
| Cryo-EM map of zebrafish cardiac F-actin | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha 1b, ... | 著者 | Bradshaw, M, Squire, J.M, Morris, E, Atkinson, G, Richardson, B, Lees, J, Paul, D.M. | 登録日 | 2023-04-13 | 公開日 | 2023-08-02 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio Rerio. J.Muscle Res.Cell.Motil., 44, 2023
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2I94
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6M0S
| 3.6A Yeast Vo state3 prime | 分子名称: | Uncharacterized protein YPR170W-B, V-type proton ATPase subunit a, vacuolar isoform, ... | 著者 | Roh, S.H, Shekhar, M, Pintilie, G, Chipot, C, Wilkens, S, SIngharoy, A, Chiu, W. | 登録日 | 2020-02-22 | 公開日 | 2020-11-04 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of V o complex. Sci Adv, 6, 2020
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6VW2
| Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils | 分子名称: | Islet amyloid polypeptide (SUMO-tagged) | 著者 | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2020-02-18 | 公開日 | 2020-06-10 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils. Nat.Struct.Mol.Biol., 27, 2020
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6NGR
| Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-fluoro-5-(2-((2R,4S)-4-fluoro-1-methylpyrrolidin-2-yl)ethyl)phenethyl)-4-methylpyridin-2-amine | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-[2-(3-fluoro-5-{2-[(2R,4S)-4-fluoro-1-methylpyrrolidin-2-yl]ethyl}phenyl)ethyl]-4-methylpyridin-2-amine, ACETATE ION, ... | 著者 | Li, H, Poulos, T.L. | 登録日 | 2018-12-21 | 公開日 | 2019-03-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.819 Å) | 主引用文献 | Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. J. Med. Chem., 62, 2019
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6NGN
| Structure of rat neuronal nitric oxide synthase heme domain in complex with (S)-6-(3-fluoro-5-(2-(pyrrolidin-2-yl)ethyl)phenethyl)-4-methylpyridin-2-amine | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-[2-(3-fluoro-5-{2-[(2S)-pyrrolidin-2-yl]ethyl}phenyl)ethyl]-4-methylpyridin-2-amine, ACETATE ION, ... | 著者 | Li, H, Poulos, T.L. | 登録日 | 2018-12-21 | 公開日 | 2019-03-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. J. Med. Chem., 62, 2019
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2LQD
| Reduced and CO-bound cytochrome P450cam (CYP101A1) | 分子名称: | CARBON MONOXIDE, Camphor 5-monooxygenase, POTASSIUM ION, ... | 著者 | Pochapsky, T.C, Pochapsky, S.S, Asciutto, E, Madura, J, Young, M.J. | 登録日 | 2012-03-02 | 公開日 | 2012-05-09 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structural Ensembles of Substrate-Free Cytochrome P450(cam). Biochemistry, 51, 2012
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6NG3
| Crystal structure of human CD160 and HVEM complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD160 antigen,Tumor necrosis factor receptor superfamily member 14, MAGNESIUM ION, ... | 著者 | Liu, W, Bonanno, J, Almo, S.C. | 登録日 | 2018-12-21 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | Structural Basis of CD160:HVEM Recognition. Structure, 27, 2019
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6NGM
| Structure of rat neuronal nitric oxide synthase heme domain in complex with (R)-6-(3-fluoro-5-(2-(1-methylpyrrolidin-2-yl)ethyl)phenethyl)-4-methylpyridin-2-amine | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-[2-(3-fluoro-5-{2-[(2R)-1-methylpyrrolidin-2-yl]ethyl}phenyl)ethyl]-4-methylpyridin-2-amine, ACETATE ION, ... | 著者 | Li, H, Poulos, T.L. | 登録日 | 2018-12-21 | 公開日 | 2019-03-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.693 Å) | 主引用文献 | Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. J. Med. Chem., 62, 2019
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6NGZ
| Structure of rat neuronal nitric oxide synthase heme domain in complex with (S)-6-(2,3-difluoro-5-(2-(1-methylpyrrolidin-2-yl)ethyl)phenethyl)-4-methylpyridin-2-amine | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-[2-(2,3-difluoro-5-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}phenyl)ethyl]-4-methylpyridin-2-amine, ACETATE ION, ... | 著者 | Li, H, Poulos, T.L. | 登録日 | 2018-12-21 | 公開日 | 2019-03-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. J. Med. Chem., 62, 2019
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6NGS
| Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(5-(3-(dimethylamino)propyl)-2,3-difluorophenethyl)-4-methylpyridin-2-amine | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{5-[3-(dimethylamino)propyl]-2,3-difluorophenyl}ethyl)-4-methylpyridin-2-amine, ACETATE ION, ... | 著者 | Li, H, Poulos, T.L. | 登録日 | 2018-12-21 | 公開日 | 2019-03-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. J. Med. Chem., 62, 2019
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7MC6
| Crystal structure of the SARS-CoV-2 ExoN-nsp10 complex containing Mg2+ ion | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Moeller, N.M, Shi, K, Banerjee, S, Yin, L, Aihara, H. | 登録日 | 2021-04-01 | 公開日 | 2021-05-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN. Proc.Natl.Acad.Sci.USA, 119, 2022
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6FXT
| Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP-Glc | 分子名称: | 2-OXOGLUTARIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Scietti, L, Chiapparino, A, De Giorgi, F, Fumagalli, M, Khoriauli, L, Nergadze, S, Basu, S, Olieric, V, Banushi, B, Giulotto, E, Gissen, P, Forneris, F. | 登録日 | 2018-03-09 | 公開日 | 2018-08-22 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3. Nat Commun, 9, 2018
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6GEO
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6GEQ
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2K4C
| tRNAPhe-based homology model for tRNAVal refined against base N-H RDCs in two media and SAXS data | 分子名称: | 76-MER | 著者 | Grishaev, A, Ying, J, Canny, M.D, Pardi, A, Bax, A. | 登録日 | 2008-06-04 | 公開日 | 2008-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR, SOLUTION SCATTERING | 主引用文献 | Solution structure of tRNAVal from refinement of homology model against residual dipolar coupling and SAXS data. J.Biomol.Nmr, 42, 2008
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2LTQ
| High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data | 分子名称: | Disulfide bond formation protein B, Fab fragment heavy chain, Fab fragment light chain, ... | 著者 | Tang, M, Sperling, L.J, Schwieters, C.D, Nesbitt, A.E, Gennis, R.B, Rienstra, C.M. | 登録日 | 2012-05-30 | 公開日 | 2013-02-27 | 最終更新日 | 2023-06-14 | 実験手法 | SOLID-STATE NMR | 主引用文献 | Structure of the Disulfide Bond Generating Membrane Protein DsbB in the Lipid Bilayer. J.Mol.Biol., 425, 2013
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2KLE
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2MIB
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2M43
| DNA containing a cluster of 8-oxo-guanine and abasic site lesion: alpha anomer (AP6, 8OG 14) | 分子名称: | DNA (5'-D(*CP*GP*CP*TP*CP*(ORP)P*CP*AP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*(8OG)P*TP*GP*GP*GP*AP*GP*CP*G)-3') | 著者 | Zalesak, J, Jourdan, M, Constant, J, Lourdin, M. | 登録日 | 2013-01-29 | 公開日 | 2014-01-08 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and dynamics of DNA duplexes containing a cluster of mutagenic 8-oxoguanine and abasic site lesions. J.Mol.Biol., 426, 2014
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2LYR
| NOE-based 3D structure of the monomeric partially-folded intermediate of CylR2 at 259K (-14 Celsius degrees) | 分子名称: | CylR2 | 著者 | Jaremko, M, Jaremko, L, Kim, H, Cho, M, Schwieters, C.D, Giller, K, Becker, S, Zweckstetter, M. | 登録日 | 2012-09-19 | 公開日 | 2013-02-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Cold denaturation of a protein dimer monitored at atomic resolution. Nat.Chem.Biol., 9, 2013
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6Q9T
| Protein-aromatic foldamer complex crystal structure | 分子名称: | Aromatic foldamer, Carbonic anhydrase 2, ZINC ION | 著者 | Post, S, Langlois d'Estaintot, B, Fischer, L, Granier, T, Huc, I. | 登録日 | 2018-12-18 | 公開日 | 2019-09-18 | 最終更新日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Structure Elucidation of Helical Aromatic Foldamer-Protein Complexes with Large Contact Surface Areas. Chemistry, 25, 2019
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3QI2
| A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Bosch, D.E, Willard, F.S, Kimple, A.J, Miley, M.J, Siderovski, D.P. | 登録日 | 2011-01-26 | 公開日 | 2012-02-01 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.797 Å) | 主引用文献 | A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis Plos Pathog., 8, 2012
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6QPA
| Halothiobacillus neapolitanus sulfur oxygenase reductase | 分子名称: | FE (III) ION, SULFATE ION, Sulfur oxygenase/reductase | 著者 | Frazao, C, Klezin, A, Poell, U, Veith, A, Ruehl, P, Coelho, R. | 登録日 | 2019-02-13 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Multiple sulfane modifications in active-site cysteine thiols of two sulfur oxygenase reductases and analysis of substrate/product channels To Be Published
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3QBJ
| Crystal structure of dipeptidyl peptidase IV in complex with inhibitor | 分子名称: | 1-[(3S,4S)-4-amino-1-(6-phenylpyrimidin-4-yl)pyrrolidin-3-yl]piperidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Liu, S.P. | 登録日 | 2011-01-13 | 公開日 | 2012-01-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Crystal structure of dipeptidyl peptidase IV in complex with inhibitor To be Published
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