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2C30
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Crystal Structure Of The Human P21-Activated Kinase 6
分子名称: CHLORIDE ION, PHOSPHATE ION, SERINE/THREONINE-PROTEIN KINASE PAK 6
著者Filippakopoulos, P, Berridge, G, Bray, J, Burgess, N, Colebrook, S, Das, S, Eswaran, J, Gileadi, O, Papagrigoriou, E, Savitsky, P, Smee, C, Turnbull, A, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, von Delft, F, Knapp, S.
登録日2005-10-02
公開日2006-02-08
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
Structure, 15, 2007
2BZ5
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Structure-based Discovery of a New Class of Hsp90 Inhibitors
分子名称: 2,5-DICHLORO-N-[4-HYDROXY-3-(2-HYDROXY-1-NAPHTHYL)PHENYL]BENZENESULFONAMIDE, HEAT SHOCK PROTEIN HSP90-ALPHA
著者Barril, X, Brough, P, Drysdale, M, Hubbard, R.E, Massey, A, Surgenor, A, Wright, L.
登録日2005-08-11
公開日2005-10-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure-Based Discovery of a New Class of Hsp90 Inhibitors.
Bioorg.Med.Chem.Lett., 15, 2005
2VW8
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Crystal Structure of Quinolone signal response protein pqsE from Pseudomonas aeruginosa
分子名称: 1,2-ETHANEDIOL, CACODYLATE ION, FE (II) ION, ...
著者Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, Oke, M, Naismith, J.H, White, M.F.
登録日2008-06-17
公開日2010-07-14
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genomics, 11, 2010
7ZJ4
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Ligand bound state of a brocolli-pepper aptamer FRET tile
分子名称: 4-(3,5-difluoro-4-hydroxybenzyl)-1,2-dimethyl-1H-imidazol-5-ol, 4-[(~{Z})-1-cyano-2-[5-[2-hydroxyethyl(methyl)amino]thieno[3,2-b]thiophen-2-yl]ethenyl]benzenecarbonitrile, POTASSIUM ION, ...
著者McRae, E.K.S, Vallina, N.S, Hansen, B.K, Boussebayle, A, Andersen, E.S.
登録日2022-04-08
公開日2023-04-19
実験手法ELECTRON MICROSCOPY (4.43 Å)
主引用文献Structure determination of Pepper-Broccoli FRET pair by RNA origami scaffolding
To Be Published
7ZNZ
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Crystal structure of unliganded form of FucOB, a GH95 family alpha-1,2-fucosidase from Akkermansia muciniphila
分子名称: FucOB, a GH95 family alpha-1,2-fucosidase, GLYCEROL
著者Anso, I, Cifuente, J.O, Trastoy, B, Guerin, M.E.
登録日2022-04-23
公開日2023-04-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Turning universal O into rare Bombay type blood.
Nat Commun, 14, 2023
7ZGL
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Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor
分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Snee, M, Levy, C, Kavanagh, M.
登録日2022-04-04
公開日2023-04-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor
To Be Published
7ZO0
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Crystal structure of catalytic inactive unliganded form of FucOB, a GH95 family alpha-1,2-fucosidase from Akkermansia muciniphila
分子名称: GH95 family alpha-1,2-fucosidase, GLYCEROL
著者Anso, I, Cifuente, J.O, Trastoy, B, Guerin, M.E.
登録日2022-04-23
公開日2023-04-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Turning universal O into rare Bombay type blood.
Nat Commun, 14, 2023
7ZLL
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BU of 7zll by Molmil
Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum in complex with the 5-[(morpholin-4-yl)methyl]quinolin-8-ol inhibitor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(morpholin-4-ylmethyl)quinolin-8-ol, UDP-glucose-glycoprotein glucosyltransferase-like protein, ...
著者Roversi, P, Zitzmann, N, Bayo, Y, Kantsadi, A.L, Chandran, A.V.
登録日2022-04-15
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.649 Å)
主引用文献A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint.
Iscience, 26, 2023
2VEV
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BU of 2vev by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR
分子名称: MAGNESIUM ION, N-[(1S)-1-(4-benzyl-1H-imidazol-2-yl)-2-{4-[(5S)-1,1-dioxido-3-oxoisothiazolidin-5-yl]phenyl}ethyl]-3-(trifluoromethyl)benzenesulfonamide, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
著者Douty, B, Wayland, B, Ala, P.J, Bower, M.J, Pruitt, J, Bostrom, L, Wei, M, Klabe, R, Gonneville, L, Wynn, R, Burn, T.C, Liu, P.C.C, Combs, A.P, Yue, E.W.
登録日2007-10-27
公開日2007-11-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Isothiazolidinone Inhibitors of Ptp1B Containing Imidazoles and Imidazolines
Bioorg.Med.Chem.Lett., 18, 2008
4CST
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Crystal structure of FimH in complex with 3'-Chloro-4'-(alpha-D-mannopyranosyloxy)-biphenyl-4-carbonitrile
分子名称: 3'-chloro-4'-(alpha-D-mannopyranosyloxy)biphenyl-4-carbonitrile, PROTEIN FIMH
著者Kleeb, S, Pang, L, Mayer, K, Sigl, A, Eris, D, Preston, R.C, Zihlmann, P, Abgottspon, D, Hutter, A, Scharenberg, M, Jian, X, Navarra, G, Rabbani, S, Smiesko, M, Luedin, N, Jakob, R.P, Schwardt, O, Maier, T, Sharpe, T, Ernst, B.
登録日2014-03-10
公開日2015-02-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Fimh Antagonists: Bioisosteres to Improve the in Vitro and in Vivo Pk/Pd Profile.
J.Med.Chem., 58, 2015
7ZRR
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BU of 7zrr by Molmil
Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK965
分子名称: 1,2-ETHANEDIOL, 1,3,5-tris(bromomethyl)benzene, AMINO GROUP, ...
著者Caregnato, A, Angela, P, Mazzoccato, Y, Frasson, N, Angelini, A, Cendron, L.
登録日2022-05-05
公開日2023-11-15
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK965
To Be Published
7ZRT
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Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK970
分子名称: 1,2-ETHANEDIOL, 1,3,5-tris(bromomethyl)benzene, DI(HYDROXYETHYL)ETHER, ...
著者Caregnato, A, Angela, P, Mazzoccato, Y, Frasson, N, Angelini, A, Cendron, L.
登録日2022-05-05
公開日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK970
To Be Published
2X0O
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BU of 2x0o by Molmil
Apo structure of the Alcaligin biosynthesis protein C (AlcC) from Bordetella bronchiseptica
分子名称: ALCALIGIN BIOSYNTHESIS PROTEIN, SULFATE ION
著者Johnson, K.A, Schmelz, S, Kadi, N, Mcmahon, S.A, Oke, M, Liu, H, Carter, L.G, White, M.F, Challis, G.L, Naismith, J.H.
登録日2009-12-16
公開日2010-07-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genomics, 11, 2010
2X4J
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Crystal structure of ORF137 from Pyrobaculum spherical virus
分子名称: HYPOTHETICAL PROTEIN ORF137
著者Oke, M, Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, White, M.F, Naismith, J.H.
登録日2010-02-01
公開日2010-07-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genomics, 11, 2010
4E6P
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BU of 4e6p by Molmil
Crystal structure of a probable sorbitol dehydrogenase (Target PSI-012078) from Sinorhizobium meliloti 1021
分子名称: 1,2-ETHANEDIOL, Probable sorbitol dehydrogenase (L-iditol 2-dehydrogenase), SODIUM ION
著者Kumar, P.R, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
登録日2012-03-15
公開日2012-04-11
実験手法X-RAY DIFFRACTION (2.096 Å)
主引用文献Crystal structure of a probable sorbitol dehydrogenase from Sinorhizobium meliloti 1021
to be published
2VCF
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BU of 2vcf by Molmil
Structure of isoniazid (INH) bound to cytosolic soybean ascorbate peroxidase
分子名称: 4-(DIAZENYLCARBONYL)PYRIDINE, ASCORBATE PEROXIDASE FROM SOYBEAN CYTOSOL, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Metcalfe, C.L, Macdonald, I.K, Brown, K.A, Raven, E.L, Moody, P.C.E.
登録日2007-09-21
公開日2007-12-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Tuberculosis Prodrug Isoniazid Bound to Activating Peroxidases.
J.Biol.Chem., 283, 2008
2VEW
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR
分子名称: 3-fluoro-N-[(1S)-1-[4-[(2-fluorophenyl)methyl]imidazol-2-yl]-2-[4-[(5S)-1,1,3-trioxo-1,2-thiazolidin-5-yl]phenyl]ethyl]benzenesulfonamide, MAGNESIUM ION, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
著者Douty, B, Wayland, B, Ala, P.J, Bower, M.J, Pruitt, J, Bostrom, L, Wei, M, Klabe, R, Gonneville, L, Wynn, R, Burn, T.C, Liu, P.C.C, Combs, A.P, Yue, E.W.
登録日2007-10-27
公開日2007-11-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Isothiazolidinone Inhibitors of Ptp1B Containing Imidazoles and Imidazolines
Bioorg.Med.Chem.Lett., 18, 2008
2X3E
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BU of 2x3e by Molmil
Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase III, FabH from Pseudomonas aeruginosa PAO1
分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 3
著者Oke, M, Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, White, M.F, Naismith, J.H.
登録日2010-01-24
公開日2010-07-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genomics, 11, 2010
2X3L
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Crystal Structure of the Orn_Lys_Arg decarboxylase family protein SAR0482 from Methicillin-resistant Staphylococcus aureus
分子名称: 1,2-ETHANEDIOL, ORN/LYS/ARG DECARBOXYLASE FAMILY PROTEIN, PYRIDOXAL-5'-PHOSPHATE, ...
著者Oke, M, Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, White, M.F, Naismith, J.H.
登録日2010-01-25
公開日2010-07-21
最終更新日2015-11-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genomics, 11, 2010
2X5C
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Crystal structure of hypothetical protein ORF131 from Pyrobaculum Spherical Virus
分子名称: GLYCEROL, HYPOTHETICAL PROTEIN ORF131, ZINC ION
著者Oke, M, Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, White, M.F, Naismith, J.H.
登録日2010-02-08
公開日2010-07-21
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genom., 11, 2010
2X4G
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Crystal structure of PA4631, a nucleoside-diphosphate-sugar epimerase from Pseudomonas aeruginosa
分子名称: NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE
著者Oke, M, Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, White, M.F, Naismith, J.H.
登録日2010-01-30
公開日2010-07-21
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genomics, 11, 2010
4BCK
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Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
分子名称: 3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ...
著者Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M.
登録日2012-10-02
公開日2013-03-06
実験手法X-RAY DIFFRACTION (2.052 Å)
主引用文献Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
2X5F
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BU of 2x5f by Molmil
Crystal structure of the methicillin-resistant Staphylococcus aureus Sar2028, an aspartate_tyrosine_phenylalanine pyridoxal-5'-phosphate dependent aminotransferase
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ASPARTATE_TYROSINE_PHENYLALANINE PYRIDOXAL-5' PHOSPHATE-DEPENDENT AMINOTRANSFERASE, MAGNESIUM ION, ...
著者Oke, M, Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, White, M.F, Naismith, J.H.
登録日2010-02-08
公開日2010-07-21
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genom., 11, 2010
2X5Q
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Crystal Structure of Hypothetical protein sso1986 from Sulfolobus solfataricus P2
分子名称: SSO1986
著者Oke, M, Carter, L, Johnson, K.A, Kerou, M, Liu, H, Mcmahon, S, Naismith, J.H, White, M.F.
登録日2010-02-10
公開日2010-07-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genomics, 11, 2010
4ESK
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Crystal structure of a strand-swapped dimer of Mouse Leukocyte-associated immunoglobulin-like receptor 1 (NYSGRC-006047)IG-like domain
分子名称: GLYCEROL, Leukocyte-associated immunoglobulin-like receptor 1, POTASSIUM ION, ...
著者Sampathkumar, P, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)
登録日2012-04-23
公開日2012-05-02
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.762 Å)
主引用文献Crystal structure of a strand-swapped dimer of Mouse Leukocyte-associated immunoglobulin-like receptor 1 IG-like domain
to be published

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