PDB: 8880 件ウェブページステータス検索Chemie searchBIRD

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7QLB	SMYD3 in complex with fragment FL06268 分子名称: 1-methylimidazole-4-sulfonamide, Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ... 著者 Lund, B.A, Cederfelt, D, Dobritzsch, D. 登録日 2021-12-20 公開日 2023-03-29 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening Rsc Med Chem, 2024
7QNU	SMYD3 in complex with fragment FL08619 分子名称: BENZOYL-FORMIC ACID, Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ... 著者 Lund, B.A, Cederfelt, D, Dobritzsch, D. 登録日 2021-12-22 公開日 2023-04-05 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening Rsc Med Chem, 2024
7QNR	SMYD3 in complex with fragment FL01791 分子名称: 3-propan-2-yl-1,2,4-thiadiazol-5-amine, Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ... 著者 Lund, B.A, Cederfelt, D, Dobritzsch, D. 登録日 2021-12-22 公開日 2023-04-05 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening Rsc Med Chem, 2024
6O9O	Crystal Structure of SMYD3 with Potent and Selective Isoxazole Amide Inhibitor 1 分子名称: 5-cyclopropyl-N-{1-[({trans-4-[(4,4,4-trifluorobutyl)amino]cyclohexyl}methyl)sulfonyl]piperidin-4-yl}-1,2-oxazole-3-carboxamide, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-03-14 公開日 2020-03-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.586 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors To be published
6P6K	Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors 分子名称: 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SMYD3, MAGNESIUM ION, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-06-04 公開日 2020-01-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. Acs Med.Chem.Lett., 11, 2020
5O85	p34-p44 complex 分子名称: General transcription factor IIH subunit 2, General transcription factor IIH subunit 3, ZINC ION 著者 Radu, L, Poterszman, A. 登録日 2017-06-12 公開日 2017-10-18 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH. Nucleic Acids Res., 45, 2017
5OMG	p38alpha in complex with pyrazolobenzothiazine inhibitor COXP4M12 分子名称: 3-(4-fluorophenyl)-4-methyl-1~{H}-pyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Buehrmann, M, Rauh, D. 登録日 2017-07-31 公開日 2019-03-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38 alpha MAPK inhibitors. Biochem.Biophys.Res.Commun., 511, 2019
5OMH	p38alpha in complex with pyrazolobenzothiazine inhibitor COXH11 分子名称: 1-(3-chlorophenyl)-3-methyl-4~{H}-pyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide, Mitogen-activated protein kinase 14 著者 Buehrmann, M, Rauh, D. 登録日 2017-07-31 公開日 2019-03-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38 alpha MAPK inhibitors. Biochem.Biophys.Res.Commun., 511, 2019
6KIX	Cryo-EM structure of human MLL1-NCP complex, binding mode1 分子名称: DNA (145-MER), GLUTAMINE, Histone H2A, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
6KIV	Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom) 分子名称: DNA (145-MER), Histone H2A, Histone H2B 1.1, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
6KIZ	Cryo-EM structure of human MLL1-NCP complex, binding mode2 分子名称: DNA (145-MER), Histone H2A, Histone H2B 1.1, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
6KIU	Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom) 分子名称: DNA (145-MER), GLUTAMINE, Histone H2A, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
4WZS	Crystal structure of the Mot1 N-terminal domain in complex with TBP and NC2 bound to a promoter DNA fragment 分子名称: DNA (5'-D(P*CP*CP*AP*CP*CP*CP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*CP*CP*T)-3'), DNA (5'-D(P*GP*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*GP*GP*GP*TP*GP*G)-3'), ECU04_1440 protein, ... 著者 Butryn, A, Hopfner, K.-P. 登録日 2014-11-20 公開日 2015-08-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.78 Å) 主引用文献 Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1. Elife, 4, 2015
6DAT	ETS1 in complex with synthetic SRR mimic 分子名称: Protein C-ets-1, SULFATE ION, serine-rich region (SRR) peptide 著者 Perez-Borrajero, C, Okon, M, Lin, C.S, Scheu, K, Murphy, M.E.P, Graves, B.J, McIntosh, L.P. 登録日 2018-05-02 公開日 2019-01-16 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.35002637 Å) 主引用文献 The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor. J. Mol. Biol., 431, 2019
6DMB	Cryo-EM structure of human Ptch1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... 著者 Yan, N, Gong, X, Qian, H.W. 登録日 2018-06-04 公開日 2018-07-11 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science, 361, 2018
7XXH	Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11 分子名称: 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(11) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B. 登録日 2022-05-30 公開日 2023-06-07 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R. Protein Cell, 14, 2023
7Y1J	Structure of SUR2A in complex with Mg-ATP and repaglinide in the inward-facing conformation. 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ... 著者 Chen, L, Ding, D, Hou, T. 登録日 2022-06-08 公開日 2023-06-14 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
6DEC	Crystal structure of Bos taurus Arp2/3 complex binding with C-terminus of Homo sapiens SPIN90 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, ... 著者 Nolen, B.J, Luan, Q. 登録日 2018-05-11 公開日 2018-10-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.6 Å) 主引用文献 Structure of the nucleation-promoting factor SPIN90 bound to the actin filament nucleator Arp2/3 complex. EMBO J., 37, 2018
7Y1L	Structure of SUR2B in complex with Mg-ATP and repaglinide in the inward-facing conformation 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ... 著者 Chen, L, Ding, D, Hou, T. 登録日 2022-06-08 公開日 2023-06-14 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.73 Å) 主引用文献 The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
7Y1K	Structure of SUR2A in complex with Mg-ATP, Mg-ADP and repaglinide in the inward-facing conformation 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, ... 著者 Chen, L, Ding, D, Hou, T. 登録日 2022-06-08 公開日 2023-06-14 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
7Y1M	Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the inward-facing conformation 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ... 著者 Chen, L, Ding, D, Hou, T. 登録日 2022-06-08 公開日 2023-06-14 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.57 Å) 主引用文献 The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
7Y1N	Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the partially occluded state 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ... 著者 Chen, L, Ding, D, Hou, T. 登録日 2022-06-08 公開日 2023-06-14 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.61 Å) 主引用文献 The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
7YB4	Solution structure of homeodomain of EXTRADENTICLE 分子名称: Homeobox protein extradenticle 著者 Acharya, B, Basak, A.J, Lee, W, De, S. 登録日 2022-06-28 公開日 2023-07-26 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structure of homeodomain of EXTRADENTICLE To Be Published
6DMY	Cryo-EM structure of human Ptch1 and ShhN complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Yan, N, Gong, X, Qian, H.W. 登録日 2018-06-05 公開日 2018-07-11 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science, 361, 2018
6IGM	Cryo-EM Structure of Human SRCAP Complex 分子名称: Actin-related protein 6, Helicase SRCAP, RuvB-like 1, ... 著者 Feng, Y, Tian, Y, Wu, Z, Xu, Y. 登録日 2018-09-25 公開日 2019-07-24 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Cryo-EM structure of human SRCAP complex. Cell Res., 28, 2018

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