PDB: 2199 件ウェブページステータス検索Chemie searchBIRD

---

5CPE	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-cycloheptyl-1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-07-21 公開日 2016-01-13 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5COI	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: 1-({[(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)sulfonyl]amino}methyl)cyclopentanecarboxylic acid, Bromodomain-containing protein 4 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-07-20 公開日 2016-01-13 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5CP5	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: 1,2-ETHANEDIOL, 1-ethyl-N-(4-fluorophenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide, Bromodomain-containing protein 4, ... 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-07-21 公開日 2016-01-13 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5CS8	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GLYCEROL, ... 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-07-23 公開日 2016-01-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5D0C	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GLYCEROL, ... 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-08-03 公開日 2016-01-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5CTL	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: Bromodomain-containing protein 4, N-(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)benzenesulfonamide 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-07-24 公開日 2016-01-13 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5CRM	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, ... 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-07-23 公開日 2016-01-13 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5CY9	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GLYCEROL, ... 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-07-30 公開日 2016-01-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5CQT	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: Bromodomain-containing protein 4, N-cyclohexyl-1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-07-22 公開日 2016-01-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5CRZ	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: 1,2-ETHANEDIOL, 2-chloro-N-(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)-4-fluorobenzenesulfonamide, Bromodomain-containing protein 4, ... 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-07-23 公開日 2016-01-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5EI4	First domain of human bromodomain BRD4 in complex with inhibitor 8-(5-Amino-1H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-(4-chlorobenzyl)-7-ethyl-3,7-dihydropurine-2,6-dione 分子名称: 1,2-ETHANEDIOL, 8-[(3-azanyl-1~{H}-1,2,4-triazol-5-yl)sulfanylmethyl]-3-[(4-chlorophenyl)methyl]-7-ethyl-purine-2,6-dione, Bromodomain-containing protein 4 著者 Raux, B, Rebuffet, E, Betzi, S, Morelli, X. 登録日 2015-10-29 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins. J.Med.Chem., 59, 2016
5EIS	FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 3-(4-Chlorobenzyl)-7-ethyl-3,7-dihydropurine-2,6-dione 分子名称: 1,2-ETHANEDIOL, 3-[(4-chlorophenyl)methyl]-7-ethyl-purine-2,6-dione, Bromodomain-containing protein 4 著者 Raux, B, Rebuffet, E, Betzi, S, Morelli, X. 登録日 2015-10-30 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins. J.Med.Chem., 59, 2016
5EGU	FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 3-Butyl-8-(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanylmethyl)-7-ethyl-3,7-dihydropurine-2,6-dione 分子名称: 1,2-ETHANEDIOL, 3-butyl-8-[(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanylmethyl]-7-ethyl-purine-2,6-dione, Bromodomain-containing protein 4 著者 Raux, B, Rebuffet, E, Betzi, S, Priet, S, Morelli, X. 登録日 2015-10-27 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins. J.Med.Chem., 59, 2016
5HEL	Crystal structure of the N-terminus Y153H bromodomain mutant of human BRD2 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 2 著者 Tallant, C, Lori, C, Pasquo, A, Chiaraluce, R, Consalvi, V, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S. 登録日 2016-01-06 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Crystal structure of the N-terminus Y153H bromodomain mutant of human BRD2 To Be Published
5HEN	Crystal structure of the N-terminus R100L bromodomain mutant of human BRD2 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 2 著者 Tallant, C, Lori, C, Pasquo, A, Chiaraluce, R, Consalvi, V, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S. 登録日 2016-01-06 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Crystal structure of the N-terminus R100L bromodomain mutant of human BRD2 To Be Published
5HFQ	Crystal structure of the second bromodomain Q443H mutant of human BRD2 分子名称: Bromodomain-containing protein 2 著者 Tallant, C, Lori, C, Pasquo, A, Chiaraluce, R, Consalvi, V, Fonseca, M, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S. 登録日 2016-01-07 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal structure of the second bromodomain Q443H mutant of human BRD2 To Be Published
5HEM	Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Bromodomain-containing protein 2, ... 著者 Tallant, C, Lori, C, Pasquo, A, Chiaraluce, R, Consalvi, V, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S. 登録日 2016-01-06 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2 To Be Published
5HFR	Crystal structure of the second bromodomain H395R mutant of human BRD3 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 3, NITRATE ION 著者 Tallant, C, Lori, C, Pasquo, A, Chiaraluce, R, Consalvi, V, Fonseca, M, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S. 登録日 2016-01-07 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of the second bromodomain H395R mutant of human BRD3 To Be Published
5D3J	First bromodomain of BRD4 bound to inhibitor XD33 分子名称: 4-acetyl-N-[3-(diethylsulfamoyl)phenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 著者 Wohlwend, D, Huegle, M. 登録日 2015-08-06 公開日 2016-01-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016
5D3R	First bromodomain of BRD4 bound to inhibitor XD42 分子名称: 4-acetyl-N-[3-(azepan-1-ylsulfonyl)phenyl]-5-methyl-3-propyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 著者 Wohlwend, D, Huegle, M. 登録日 2015-08-06 公開日 2016-01-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016
5D3L	First bromodomain of BRD4 bound to inhibitor XD35 分子名称: 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxy-4-methylphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 著者 Wohlwend, D, Huegle, M. 登録日 2015-08-06 公開日 2016-01-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016
5D3P	First bromodomain of BRD4 bound to inhibitor XD41 分子名称: 1-[(4-acetyl-3-ethyl-5-methyl-1H-pyrrol-2-yl)carbonyl]-N-methyl-1H-indole-6-sulfonamide, Bromodomain-containing protein 4, NICKEL (II) ION 著者 Wohlwend, D, Huegle, M. 登録日 2015-08-06 公開日 2016-01-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016
5D26	First bromodomain of BRD4 bound to inhibitor XD28 分子名称: (R,R)-2,3-BUTANEDIOL, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ... 著者 Wohlwend, D, Huegle, M. 登録日 2015-08-05 公開日 2016-01-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016
5D25	First bromodomain of BRD4 bound to inhibitor XD27 分子名称: (R,R)-2,3-BUTANEDIOL, 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3,5-dimethyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4, ... 著者 Wohlwend, D, Huegle, M, Gerhardt, S. 登録日 2015-08-05 公開日 2016-01-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016
5D3N	First bromodomain of BRD4 bound to inhibitor XD40 分子名称: 4-acetyl-3-ethyl-5-methyl-N-[2-methyl-5-(methylsulfamoyl)phenyl]-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 著者 Wohlwend, D, Huegle, M. 登録日 2015-08-06 公開日 2016-01-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016

<10111213141516171819202122232425>