PDB: 615 件ウェブページステータス検索Chemie searchBIRD

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6Q0T	Structure of a MAPK pathway complex 分子名称: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Park, E, Rawson, S, Jeon, H, Eck, M.J. 登録日 2019-08-02 公開日 2019-10-09 最終更新日 2020-04-22 実験手法 ELECTRON MICROSCOPY (5.7 Å) 主引用文献 Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
6Q0J	Structure of a MAPK pathway complex 分子名称: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Park, E, Rawson, S, Jeon, H, Eck, M.J. 登録日 2019-08-01 公開日 2019-10-09 最終更新日 2020-04-22 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
6Q0K	Structure of a MAPK pathway complex 分子名称: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf 著者 Park, E, Rawson, S, Jeon, H, Eck, M.J. 登録日 2019-08-01 公開日 2019-10-09 最終更新日 2020-04-22 実験手法 ELECTRON MICROSCOPY (6.8 Å) 主引用文献 Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
6SAD	Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on Ser139 and Ser164 分子名称: 14-3-3 protein gamma, Caspase-2 著者 Kalabova, D, Obsil, T, Obsilova, V. 登録日 2019-07-16 公開日 2020-01-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.753 Å) 主引用文献 14-3-3 protein binding blocks the dimerization interface of caspase-2. Febs J., 287, 2020
6S9Q	Fragment AZ-004 binding at a primary and secondary site in a p53pT387/14-3-3 complex 分子名称: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, CALCIUM ION, ... 著者 Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-07-15 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6S9K	Structure of 14-3-3 gamma in complex with caspase-2 peptide containing 14-3-3 binding motif Ser139 and NLS 分子名称: 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, Caspase-2 著者 Alblova, M, Obsil, T, Obsilova, V. 登録日 2019-07-15 公開日 2020-01-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 14-3-3 protein binding blocks the dimerization interface of caspase-2. Febs J., 287, 2020
6S40	Fragment AZ-001 binding at the p53pT387/14-3-3 sigma interface and additional sites 分子名称: 14-3-3 protein sigma, 4-chloranyl-1-benzothiophene-2-carboximidamide, CALCIUM ION, ... 著者 Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-06-26 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6S3C	Fragment AZ-019 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-phenyl-5-(piperidin-4-ylmethyl)thiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C. 登録日 2019-06-25 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6S39	Fragment AZ-018 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 5-(3-azanylpropyl)-4-phenyl-thiophene-2-carboximidamide, CALCIUM ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C. 登録日 2019-06-24 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RX2	Fragment AZ-005 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 7-[[(2~{S})-1-azanylpropan-2-yl]amino]-1-benzothiophene-2-carboximidamide, CALCIUM ION, ... 著者 Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-06-07 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RWU	Fragment AZ-010 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, Cellular tumor antigen p53, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]propanamide 著者 Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-06-06 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RWS	Fragment AZ-009 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-chloranyl-6-(sulfanylmethyl)-1-benzothiophene-2-carboximidamide, Cellular tumor antigen p53, ... 著者 Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-06-06 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RWH	Fragment AZ-007 binding at a primary and secondary binding site of the the p53pT387/14-3-3 sigma complex 分子名称: 14-3-3 protein sigma, 5-(1~{H}-imidazol-5-yl)-4-phenyl-thiophene-2-carboximidamide, CALCIUM ION, ... 著者 Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-06-05 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RWI	Fragment AZ-002 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 5-phenylthiophene-2-carboximidamide, CALCIUM ION, ... 著者 Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-06-05 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RP6	Fragment AZ-019 binding at the TAZpS89/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-phenyl-5-(piperidin-4-ylmethyl)thiophene-2-carboximidamide, CALCIUM ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-05-14 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.885 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RM5	Fragment AZ-016 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 7-(6-azanyl-5-methyl-pyridin-2-yl)-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-05-05 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.884 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RM7	Fragment AZ-026 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Somsen, B, Wolter, M, Guillory, X, Genet, S, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-05-05 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RLZ	Crystal Structure of 14-3-3zeta in complex with a macrocyclic 8-mer peptide derived from ExoS 分子名称: 14-3-3 protein zeta/delta, EtMe 著者 Wallraven, K, Grossmann, T.N, Hennig, S. 登録日 2019-05-03 公開日 2020-03-18 最終更新日 2020-03-25 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Adapting free energy perturbation simulations for large macrocyclic ligands: how to dissect contributions from direct binding and free ligand flexibility. Chem Sci, 11, 2020
6RL3	Fragment AZ-003 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 5-azanyl-4-phenyl-thiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-05-01 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RL6	Fragment AZ-024 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Cellular tumor antigen p53, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-05-01 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RL4	Fragment AZ-025 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 5-[1-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-05-01 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RK8	Fragment AZ-014 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 7-(3-azanyl-4-methyl-pyrazol-1-yl)-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-04-30 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.602 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RKK	Fragment AZ-021 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-phenyl-5-(phenylmethyl)thiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-04-30 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RKI	Fragment AZ-023 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 5-[(3-aminophenyl)amino]-4-phenyl-thiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C. 登録日 2019-04-30 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RKM	Fragment AZ-022 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-phenyl-5-phenylazanyl-thiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-04-30 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020

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