7ZM8
| CryoEM structure of mitochondrial complex I from Chaetomium thermophilum (inhibited by DDM) - membrane arm | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Laube, E, Kuehlbrandt, W. | 登録日 | 2022-04-19 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum. Sci Adv, 8, 2022
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7ZME
| CryoEM structure of mitochondrial complex I from Chaetomium thermophilum (state 2) - membrane arm | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Laube, E, Kuehlbrandt, W. | 登録日 | 2022-04-19 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum. Sci Adv, 8, 2022
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7ZMG
| CryoEM structure of mitochondrial complex I from Chaetomium thermophilum (state 1) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Laube, E, Kuehlbrandt, W. | 登録日 | 2022-04-19 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | 主引用文献 | Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum. Sci Adv, 8, 2022
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7ZMB
| CryoEM structure of mitochondrial complex I from Chaetomium thermophilum (state 2) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Laube, E, Kuehlbrandt, W. | 登録日 | 2022-04-19 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum. Sci Adv, 8, 2022
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5IXH
| Crystal Structure of Burkholderia cenocepacia BcnA | 分子名称: | (2E,6E,10E,14E,18E,22E,26E)-3,7,11,15,19,23,27,31-OCTAMETHYLDOTRIACONTA-2,6,10,14,18,22,26,30-OCTAENYL TRIHYDROGEN DIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, ... | 著者 | Loutet, S.A, Murphy, M.E.P. | 登録日 | 2016-03-23 | 公開日 | 2017-03-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance. MBio, 8, 2017
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6SX1
| Structure of Rib Standard, a Rib domain from Lactobacillus acidophilus | 分子名称: | Surface protein | 著者 | Cooper, R.E.M, Griffiths, S.C, Turkenburg, J.P, Bateman, A, Potts, J.R. | 登録日 | 2019-09-24 | 公開日 | 2019-12-18 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection. Proc.Natl.Acad.Sci.USA, 116, 2019
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4P2R
| Crystal structure of the 5cc7 TCR in complex with 5c1/I-Ek | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5c1 peptide, 5cc7 T-cell receptor alpha chain, ... | 著者 | Birnbaum, M.E, Ozkan, E, Garcia, K.C. | 登録日 | 2014-03-04 | 公開日 | 2014-05-21 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.295 Å) | 主引用文献 | Deconstructing the Peptide-MHC Specificity of T Cell Recognition. Cell, 157, 2014
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7ZSO
| human purine nucleoside phosphorylase in complex with JS-554 | 分子名称: | GLYCEROL, Purine nucleoside phosphorylase, SODIUM ION, ... | 著者 | Djukic, S, Pachl, P, Rezacova, P. | 登録日 | 2022-05-07 | 公開日 | 2023-05-17 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. J.Med.Chem., 66, 2023
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7ZSM
| human purine nucleoside phosphorylase in complex with JS-375 | 分子名称: | CHLORIDE ION, Purine nucleoside phosphorylase, SULFATE ION, ... | 著者 | Djukic, S, Pachl, P, Rezacova, P. | 登録日 | 2022-05-07 | 公開日 | 2023-05-17 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. J.Med.Chem., 66, 2023
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7ZSR
| purine nucleoside phosphorylase in complex with JS-379 | 分子名称: | ACETATE ION, Purine nucleoside phosphorylase, [(~{E})-2-[5-bromanyl-2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]phenyl]ethenyl]phosphonic acid | 著者 | Djukic, S, Pachl, P, Rezacova, P. | 登録日 | 2022-05-08 | 公開日 | 2023-05-17 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. J.Med.Chem., 66, 2023
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7ZSN
| human purine nucleoside phosphorylase in complex with JS-379 | 分子名称: | 6-tungstotellurate(VI), Purine nucleoside phosphorylase, SULFATE ION, ... | 著者 | Djukic, S, Pachl, P, Rezacova, P. | 登録日 | 2022-05-07 | 公開日 | 2023-05-17 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. J.Med.Chem., 66, 2023
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7ZSP
| human purine nucleoside phosphorylase in complex with JS-555 | 分子名称: | 6-tungstotellurate(VI), Purine nucleoside phosphorylase, SODIUM ION, ... | 著者 | Djukic, S, Pachl, P, Rezacova, P. | 登録日 | 2022-05-08 | 公開日 | 2023-05-17 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. J.Med.Chem., 66, 2023
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6N62
| Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A. | 登録日 | 2018-11-24 | 公開日 | 2019-01-09 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.803 Å) | 主引用文献 | Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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1KNJ
| Co-Crystal Structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate Synthase (ispF) from E. coli Involved in Mevalonate-Independent Isoprenoid Biosynthesis, Complexed with CMP/MECDP/Mn2+ | 分子名称: | 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, CYTIDINE-5'-MONOPHOSPHATE, ... | 著者 | Richard, S.B, Ferrer, J.L, Bowman, M.E, Lillo, A.M, Tetzlaff, C.N, Cane, D.E, Noel, J.P. | 登録日 | 2001-12-18 | 公開日 | 2002-06-18 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. J.Biol.Chem., 277, 2002
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6SW9
| IC2A model of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Coureux, P.-D, Mechulam, Y, Schmitt, E. | 登録日 | 2019-09-20 | 公開日 | 2020-02-19 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation. Commun Biol, 3, 2020
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8A3L
| Structural insights into the binding of bS1 to the ribosome | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ... | 著者 | D'Urso, G, Chat, S, Gillet, R, Giudice, E. | 登録日 | 2022-06-08 | 公開日 | 2023-05-10 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Structural insights into the binding of bS1 to the ribosome. Nucleic Acids Res., 51, 2023
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1NOC
| MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114) COMPLEXED WITH TYPE I E. COLI CHLORAMPHENICOL ACETYL TRANSFERASE AND IMIDAZOLE | 分子名称: | IMIDAZOLE, INDUCIBLE NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Crane, B.R, Arvai, A.S, Getzoff, E.D, Stuehr, D.J, Tainer, J.A. | 登録日 | 1997-09-28 | 公開日 | 1998-10-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The structure of nitric oxide synthase oxygenase domain and inhibitor complexes. Science, 278, 1997
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2WBD
| FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR | 分子名称: | FRUCTOSE-1,6-BISPHOSPHATASE 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3-ethylbenzenesulfonamide | 著者 | Ruf, A, Joseph, C, Benz, J, Fol, B, Tetaz, T, Kitas, E, Mohr, P, Kuhn, B, Wessel, H.P, Hebeisen, P, Haap, W, Huber, W, Alvarez Sanchez, R, Paehler, A, Bernadeau, A, Gubler, M, Schott, B, Tozzo, E. | 登録日 | 2009-02-26 | 公開日 | 2009-12-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Sulfonylureido Thiazoles as Fructose-1,6-Bisphosphatase Inhibitors for the Treatment of Type-2 Diabetes. Bioorg.Med.Chem.Lett., 20, 2010
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1OIZ
| The Molecular Basis of Vitamin E Retention: Structure of Human Alpha-Tocopherol Transfer Protein | 分子名称: | ALPHA-TOCOPHEROL TRANSFER PROTEIN, FRAGMENT OF TRITON X-100 | 著者 | Meier, R, Tomizaki, T, Schulze-Briese, C, Baumann, U, Stocker, A. | 登録日 | 2003-06-27 | 公開日 | 2004-01-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | The Molecular Basis of Vitamin E Retention: Structure of Human Alpha-Tocopherol Transfer Protein J.Mol.Biol., 331, 2003
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6UNM
| CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-(naphthalen-1-yl)-3-{[(2S)-3-(naphthalen-1-yl)-1-oxo-1-{(E)-[2-(pyridin-3-yl)ethylidene]amino}propan-2-yl]sulfanyl}propan-2-yl]carbamate | 著者 | Sevrioukova, I. | 登録日 | 2019-10-12 | 公開日 | 2020-02-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg.Med.Chem., 28, 2020
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2VER
| Structural model for the complex between the Dr adhesins and carcinoembryonic antigen (CEA) | 分子名称: | AFIMBRIAL ADHESIN AFA-III, ARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate | 著者 | Korotkova, N, Yang, Y, Le Trong, I, Cota, E, Demeler, B, Marchant, J, Thomas, W.E, Stenkamp, R.E, Moseley, S.L, Matthews, S. | 登録日 | 2007-10-26 | 公開日 | 2008-01-08 | 最終更新日 | 2011-07-13 | 実験手法 | SOLUTION NMR | 主引用文献 | Binding of Dr Adhesins of Escherichia Coli to Carcinoembryonic Antigen Triggers Receptor Dissociation. Mol.Microbiol., 67, 2008
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1K7H
| CRYSTAL STRUCTURE OF SHRIMP ALKALINE PHOSPHATASE | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALKALINE PHOSPHATASE, MALEIC ACID, ... | 著者 | De Backer, M.E, Mc Sweeney, S, Rasmussen, H.B, Riise, B.W, Lindley, P, Hough, E. | 登録日 | 2001-10-19 | 公開日 | 2002-07-31 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | The 1.9 A Crystal Structure of Heat-Labile Shrimp Alkaline Phosphatase J.Mol.Biol., 318, 2002
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6MYE
| Crystal structure of human Scribble PDZ1 domain in complex with internal PDZ binding motif of Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) | 分子名称: | FORMIC ACID, Protein scribble homolog, Rho guanine nucleotide exchange factor 26, ... | 著者 | Sun, Y.J, Hou, T, Gakhar, L, Fuentes, E.J. | 登録日 | 2018-11-01 | 公開日 | 2019-04-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility. J.Cell Biol., 218, 2019
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5N4O
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1JE1
| 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEX WITH GUANOSINE AND SULFATE | 分子名称: | 5'-METHYLTHIOADENOSINE PHOSPHORYLASE, GUANOSINE, SULFATE ION | 著者 | Appleby, T.C, Mathews, I.I, Porcelli, M, Cacciapuoti, G, Ealick, S.E. | 登録日 | 2001-06-15 | 公開日 | 2001-10-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus. J.Biol.Chem., 276, 2001
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