PDB: 47720 件ウェブページステータス検索Chemie searchBIRD

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6T5F	Human 14-3-3 sigma fused to the StARD1 peptide including phosphoserine-195 分子名称: 14-3-3 protein sigma, StARD1 peptide 著者 Sluchanko, N.N, Tugaeva, K.V, Titterington, J, Antson, A.A. 登録日 2019-10-16 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family. Febs J., 287, 2020
6T5H	Human 14-3-3 sigma fused to the StARD1 peptide including phosphoserine-57 分子名称: 14-3-3 protein sigma,Steroidogenic acute regulatory protein, mitochondrial, IMIDAZOLE, ... 著者 Sluchanko, N.N, Tugaeva, K.V, Titterington, J, Antson, A.A. 登録日 2019-10-16 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family. Febs J., 287, 2020
6TLG	Ligand-free state of human 14-3-3 sigma isoform 分子名称: 14-3-3 protein sigma, DI(HYDROXYETHYL)ETHER, SULFATE ION 著者 Tassone, G, Pozzi, C, Mangani, S. 登録日 2019-12-02 公開日 2020-03-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction. Acs Chem.Biol., 15, 2020
7NPG	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 22 分子名称: 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... 著者 Centorrino, F, Ottmann, C. 登録日 2021-02-26 公開日 2022-01-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
3NKX	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome 分子名称: 14-3-3 protein zeta/delta, PROPANOIC ACID, Peptide of RAF proto-oncogene serine/threonine-protein kinase 著者 Schumacher, B, Weyand, M, Ottmann, C. 登録日 2010-06-21 公開日 2010-09-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling Mol.Cell.Biol., 30, 2010
8BYO	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2023-01-18 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYE	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075313) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclobutane-1-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4G	Small molecule amidine soak in 14-3-3/ERa (AZ132) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2023-01-03 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYB	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074398) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclohexane-1-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX4	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074392) 分子名称: 14-3-3 protein sigma, 2-[3,4-bis(chloranyl)phenoxy]-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXO	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075287) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4,4-bis(fluoranyl)-1-phenoxy-cyclohexane-1-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-09 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BWZ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074393) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-ethanoylphenoxy)-2-methyl-propanamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXQ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075296) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-phenoxy-cyclohexane-1-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-09 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYF	fragment-linked stabilizer for ERa - 14-3-3 interaction (1047455) 分子名称: 14-3-3 protein sigma, PHE-PRO-ALA-TPO-VAL, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-chloranylphenoxy)-2-methyl-propanamide 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BY9	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075292) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)-4,4-bis(fluoranyl)cyclohexane-1-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZ0	single soak stabilizer for ERa - 14-3-3 interaction (AZ275) 分子名称: 14-3-3 protein sigma, 4-ethoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2022-12-14 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZA	single soak stabilizer for ERa - 14-3-3 interaction (AZ555) 分子名称: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2022-12-14 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXI	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-08 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYD	fragment-linked stabilizer for ERa - 14-3-3 interactions (1075288) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclopentane-1-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYC	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075316) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C0K	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075302) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-17 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX3	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074372) 分子名称: 14-3-3 protein sigma, 2-(4-bromanylphenoxy)-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXN	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074399) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4-phenoxy-oxane-4-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-09 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYY	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074395) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-[(4-chlorophenyl)amino]-2-methyl-propanamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-14 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4F	Small molecule amidine soak in 14-3-3/ERa (AZ037) 分子名称: 14-3-3 protein sigma, 5-(cyclohexylamino)-4-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2023-01-03 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023

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