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PDB: 84 件
7KWD
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Crystal structure of Thermus thermophilus alkaline phosphatase
分子名称: Alkaline phosphatase, L(+)-TARTARIC ACID, MAGNESIUM ION, ...
著者Gallo, G, Coelho, C, Borges, B, Negri, N, Maiello, F, Hardy, L, Wurtele, M.
登録日2020-11-30
公開日2021-04-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Dynamic cross correlation analysis of Thermus thermophilus alkaline phosphatase and determinants of thermostability.
Biochim Biophys Acta Gen Subj, 1865, 2021
6T26
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BU of 6t26 by Molmil
X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine
分子名称: Alkaline phosphatase, CHLORIDE ION, CYCLOHEXYLAMMONIUM ION, ...
著者Asgeirsson, B, Hjorleifsson, J.G, Markusson, S, Helland, R.
登録日2019-10-07
公開日2020-10-21
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.265 Å)
主引用文献X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine.
Biochem Biophys Rep, 24, 2020
5TPQ
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E. coli alkaline phosphatase D101A, D153A, R166S, E322A, K328A mutant
分子名称: Alkaline phosphatase, PHOSPHATE ION, ZINC ION
著者Sunden, F, AlSadhan, I, Lyubimov, A.Y, Doukov, T, Swan, J, Herschlag, D.
登録日2016-10-20
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution.
J. Biol. Chem., 292, 2017
3TG0
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BU of 3tg0 by Molmil
E. coli alkaline phosphatase with bound inorganic phosphate
分子名称: Alkaline phosphatase, MAGNESIUM ION, PHOSPHATE ION, ...
著者Bobyr, E, Lassila, J.K, Wiersma-Koch, H.I, Fenn, T.D, Lee, J.J, Nikolic-Hughes, I, Hodgson, K.O, Rees, D.C, Hedman, B, Herschlag, D.
登録日2011-08-16
公開日2011-11-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献High-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallography.
J.Mol.Biol., 415, 2012
4YR1
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BU of 4yr1 by Molmil
Crystal Structure of E. Coli Alkaline Phosphatase D101A/D153A in complex with inorganic phosphate
分子名称: Alkaline phosphatase, GLYCEROL, PHOSPHATE ION, ...
著者Peck, A, Herschlag, D.
登録日2015-03-13
公開日2015-04-29
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Extensive site-directed mutagenesis reveals interconnected functional units in the Alkaline Phosphatase active site.
Elife, 4, 2015
7QOW
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BU of 7qow by Molmil
Crystal structure of Vibrio alkaline phosphatase in 1.0 M NaCl
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alkaline phosphatase, ...
著者Markusson, S, Hjorleifsson, J.G, Kursula, P, Asgeirsson, B.
登録日2021-12-29
公開日2022-11-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase.
Biochemistry, 61, 2022
7QP8
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Crystal structure of Vibrio alkaline phosphatase with bound HEPES
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Alkaline phosphatase, CHLORIDE ION, ...
著者Markusson, S, Hjorleifsson, J.G, Kursula, P, Asgeirsson, B.
登録日2022-01-03
公開日2022-11-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase.
Biochemistry, 61, 2022
2ANH
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ALKALINE PHOSPHATASE (D153H)
分子名称: ALKALINE PHOSPHATASE, PHOSPHATE ION, ZINC ION
著者Murphy, J.E, Tibbitts, T.T, Kantrowitz, E.R.
登録日1995-09-06
公開日1996-01-29
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
J.Mol.Biol., 253, 1995
3WBH
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Structural characteristics of alkaline phosphatase from a moderately halophilic bacteria Halomonas sp.593
分子名称: Alkaline phosphatase, CHLORIDE ION, MAGNESIUM ION, ...
著者Arai, S, Yonezawa, Y, Ishibashi, M, Matsumoto, F, Tamada, T, Tokunaga, H, Tokunaga, M, Kuroki, R.
登録日2013-05-17
公開日2014-03-12
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural characteristics of alkaline phosphatase from the moderately halophilic bacterium Halomonas sp. 593.
Acta Crystallogr.,Sect.D, 70, 2014
5C66
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E. Coli Alkaline Phosphatase in complex with tungstate
分子名称: Alkaline phosphatase, TUNGSTATE(VI)ION, ZINC ION
著者Peck, A, Herschlag, D.
登録日2015-06-22
公開日2016-06-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Tungstate as a Transition State Analog for Catalysis by Alkaline Phosphatase.
J.Mol.Biol., 428, 2016
1SHQ
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Crystal structure of shrimp alkaline phosphatase with magnesium in M3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, SULFATE ION, ...
著者de Backer, M.M.E, McSweeney, S, Lindley, P.F, Hough, E.
登録日2004-02-26
公開日2004-08-31
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Ligand-binding and metal-exchange crystallographic studies on shrimp alkaline phosphatase.
Acta Crystallogr.,Sect.D, 60, 2004
1SHN
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BU of 1shn by Molmil
Crystal structure of shrimp alkaline phosphatase with phosphate bound
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, SULFATE ION, ...
著者de Backer, M.M.E, McSweeney, S, Lindley, P.F, Hough, E.
登録日2004-02-26
公開日2004-08-31
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Ligand-binding and metal-exchange crystallographic studies on shrimp alkaline phosphatase.
Acta Crystallogr.,Sect.D, 60, 2004
2G9Y
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BU of 2g9y by Molmil
Structure of S102T E. coli alkaline phosphatase in presence of phosphate at 2.00 A resolution
分子名称: Alkaline phosphatase, MAGNESIUM ION, PHOSPHATE ION, ...
著者Wang, J, Kantrowitz, E.R.
登録日2006-03-07
公開日2006-10-10
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine.
Protein Sci., 15, 2006
7YIX
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BU of 7yix by Molmil
The Cryo-EM Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (ScFv) Complex.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkaline phosphatase, ...
著者Yu, Y.T, Yao, D.Q, Zhang, Q, Rao, B, Xia, Y, Lu, Y, Qin, A, Ma, P.X, Cao, Y.
登録日2022-07-18
公開日2023-08-16
実験手法ELECTRON MICROSCOPY (2.96 Å)
主引用文献The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.
Nat Commun, 14, 2023
7TM9
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BU of 7tm9 by Molmil
Crystal structure of Bacterial alkaline phosphatase from Klebsiella pneumoniae
分子名称: Bacterial alkaline phosphatase, MAGNESIUM ION, ZINC ION
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2022-01-19
公開日2022-02-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of Bacterial alkaline phosphatase from Klebsiella pneumoniae
To be published
7Z00
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BU of 7z00 by Molmil
Crystal structure of Vibrio alkaline phosphatase in 1.0 M KBr
分子名称: Alkaline phosphatase, BROMIDE ION, MAGNESIUM ION, ...
著者Markusson, S, Hjorleifsson, J.G, Kursula, P, Asgeirsson, B.
登録日2022-02-21
公開日2022-11-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase.
Biochemistry, 61, 2022
7YZZ
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BU of 7yzz by Molmil
Crystal structure of Vibrio alkaline phosphatase in 0.5 M NaCl
分子名称: 1,2-ETHANEDIOL, Alkaline phosphatase, CHLORIDE ION, ...
著者Markusson, S, Hjorleifsson, J.G, Kursula, P, Asgeirsson, B.
登録日2022-02-21
公開日2022-11-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase.
Biochemistry, 61, 2022
6QSQ
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BU of 6qsq by Molmil
X-ray crystal structure of the R336L Vibrio alkaline phosphatase variant.
分子名称: 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, Alkaline phosphatase, MAGNESIUM ION, ...
著者Hjorleifsson, J.G, Helland, R, Asgeirsson, B.
登録日2019-02-21
公開日2020-01-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The high catalytic rate of the cold-active Vibrio alkaline phosphatase requires a hydrogen bonding network involving a large interface loop.
Febs Open Bio, 2020
4KJD
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RatIntestinal AP expressed in E. coli
分子名称: GLYCEROL, Intestinal-type alkaline phosphatase 1, MAGNESIUM ION
著者Ghosh, K, Anumula, R.K, Laksmaiah, B.K.
登録日2013-05-03
公開日2013-10-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Crystal structure of rat intestinal alkaline phosphatase - Role of crown domain in mammalian alkaline phosphatases.
J.Struct.Biol., 184, 2013
4KJG
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Structure of Rat Intestinal Alkaline Phosphatase expressed in insect cell
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ghosh, K, Anumula, R.K, Laksmaiah, B.K.
登録日2013-05-03
公開日2013-10-16
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Crystal structure of rat intestinal alkaline phosphatase - Role of crown domain in mammalian alkaline phosphatases.
J.Struct.Biol., 184, 2013
4KM4
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E. coli alkaline phosphatase mutant S102G/R166S in complex with inorganic phosphate
分子名称: Alkaline phosphatase, PHOSPHATE ION, ZINC ION
著者Andrews, L.D, Fenn, T.D, Herschlag, D.
登録日2013-05-08
公開日2013-07-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Ground state destabilization by anionic nucleophiles contributes to the activity of phosphoryl transfer enzymes.
Plos Biol., 11, 2013
7YIW
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BU of 7yiw by Molmil
The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Acidic pH
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkaline phosphatase, ...
著者Yu, Y.T, Yao, D.Q, Zhang, Q, Rao, B, Xia, Y, Lu, Y, Qin, A, Cao, Y.
登録日2022-07-18
公開日2023-07-19
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.
Nat Commun, 14, 2023
7YIV
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The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Basic pH
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkaline phosphatase, ...
著者Cao, Y, Qin, A, Yu, Y.T, Yao, D.Q, Zhang, Q, Rao, B, Xia, Y, Lu, Y.
登録日2022-07-18
公開日2023-07-19
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.18 Å)
主引用文献The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.
Nat Commun, 14, 2023
3MK1
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Refinement of placental alkaline phosphatase complexed with nitrophenyl
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Alkaline phosphatase, ...
著者Stec, B, Cheltsov, A, Millan, J.L.
登録日2010-04-13
公開日2011-01-19
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
Acta Crystallogr.,Sect.F, 66, 2010
3MK0
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Refinement of placental alkaline phosphatase complexed with nitrophenyl
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Alkaline phosphatase, ...
著者Stec, B, Cheltsov, A, Millan, J.L.
登録日2010-04-13
公開日2011-01-19
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
Acta Crystallogr.,Sect.F, 66, 2010

 

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