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PDB: 812 件
220L
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GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
分子名称: BENZENE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
著者Baldwin, E.P, Baase, W.A, Zhang, X.-J, Feher, V, Matthews, B.W.
登録日1997-06-25
公開日1998-03-18
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Generation of ligand binding sites in T4 lysozyme by deficiency-creating substitutions.
J.Mol.Biol., 277, 1998
155L
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CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
著者Blaber, M, Matthews, B.W.
登録日1994-06-20
公開日1994-08-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Alanine scanning mutagenesis of the alpha-helix 115-123 of phage T4 lysozyme: effects on structure, stability and the binding of solvent.
J.Mol.Biol., 246, 1995
1LI3
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T4 lysozyme mutant L99A/M102Q bound by 3-chlorophenol
分子名称: 3-CHLOROPHENOL, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
著者Wei, B.Q, Baase, W.A, Weaver, L.H, Matthews, B.W, Shoichet, B.K.
登録日2002-04-17
公開日2002-05-08
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献A Model Binding Site for Testing Scoring Functions in Molecular Docking
J.Mol.Biol., 322, 2002
1L20
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ENHANCED PROTEIN THERMOSTABILITY FROM DESIGNED MUTATIONS THAT INTERACT WITH ALPHA-HELIX DIPOLES
分子名称: T4 LYSOZYME
著者Nicholson, H, Matthews, B.W.
登録日1989-05-01
公開日1990-01-15
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Enhanced protein thermostability from designed mutations that interact with alpha-helix dipoles.
Nature, 336, 1988
1L53
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STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
分子名称: BETA-MERCAPTOETHANOL, T4 LYSOZYME
著者Daopin, S, Matthews, B.W.
登録日1991-01-28
公開日1991-10-15
最終更新日2022-11-23
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural and thermodynamic analysis of the packing of two alpha-helices in bacteriophage T4 lysozyme.
J.Mol.Biol., 221, 1991
1QT3
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T26D MUTANT OF T4 LYSOZYME
分子名称: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, PROTEIN (T4 Lysozyme)
著者Kuroki, R, Weaver, L.H, Matthews, B.W.
登録日1999-06-30
公開日1999-07-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site.
Proc.Natl.Acad.Sci.USA, 96, 1999
3C81
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Mutant K85A of T4 lysozyme in wildtype background at room temperature
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme
著者Mooers, B.H.M.
登録日2008-02-08
公開日2009-02-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme.
Protein Sci., 18, 2009
224L
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THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
著者Blaber, M, Matthews, B.W.
登録日1993-09-27
公開日1994-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Energetic cost and structural consequences of burying a hydroxyl group within the core of a protein determined from Ala-->Ser and Val-->Thr substitutions in T4 lysozyme.
Biochemistry, 32, 1993
1L88
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SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
著者Eriksson, A.E, Matthews, B.W.
登録日1992-01-21
公開日1993-10-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences.
J.Mol.Biol., 229, 1993
1L39
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CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
分子名称: T4 LYSOZYME
著者Daopin, S, Matthews, B.W.
登録日1991-01-28
公開日1991-10-15
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis.
Biochemistry, 30, 1991
1L72
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MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者Zhang, X, Matthews, B.W.
登録日1991-09-23
公開日1991-10-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability.
Protein Sci., 1, 1992
157L
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BU of 157l by Molmil
CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
著者Blaber, M, Matthews, B.W.
登録日1994-06-20
公開日1994-08-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Alanine scanning mutagenesis of the alpha-helix 115-123 of phage T4 lysozyme: effects on structure, stability and the binding of solvent.
J.Mol.Biol., 246, 1995
199L
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BU of 199l by Molmil
THERMODYNAMIC AND STRUCTURAL COMPENSATION IN "SIZE-SWITCH" CORE-REPACKING VARIANTS OF T4 LYSOZYME
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者Baldwin, E, Xu, J, Hajiseyedjavadi, O, Matthews, B.W.
登録日1995-11-06
公開日1996-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme.
J.Mol.Biol., 259, 1996
3GUK
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T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--Toluene binding
分子名称: ACETATE ION, CALCIUM ION, CHLORIDE ION, ...
著者Liu, L, Matthews, B.W.
登録日2009-03-30
公開日2009-08-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Use of stabilizing mutations to engineer a charged group within a ligand-binding hydrophobic cavity in T4 lysozyme.
Biochemistry, 48, 2009
1CV5
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BU of 1cv5 by Molmil
T4 LYSOZYME MUTANT L133M
分子名称: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME
著者Gassner, N.C, Baase, W.A, Lindstrom, J, Lu, J, Matthews, B.W.
登録日1999-08-22
公開日1999-11-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
3CDO
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Bacteriophage T4 lysozyme mutant R96V in wildtype background at low temperature
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, HEXANE-1,6-DIOL, Lysozyme, ...
著者Mooers, B.H.M.
登録日2008-02-27
公開日2009-02-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme.
Protein Sci., 18, 2009
1D2W
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N-TERMINAL DOMAIN CORE METHIONINE MUTATION
分子名称: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME
著者Gassner, N.C, Matthews, B.W.
登録日1999-09-28
公開日1999-10-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Use of differentially substituted selenomethionine proteins in X-ray structure determination.
Acta Crystallogr.,Sect.D, 55, 1999
1CUP
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METHIONINE CORE MUTANT OF T4 LYSOZYME
分子名称: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME
著者Gassner, N.C, Baase, W.A, Lindstrom, J.D, Lu, J, Matthews, B.W.
登録日1999-08-20
公開日1999-11-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1KW7
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METHIONINE CORE MUTANT OF T4 LYSOZYME
分子名称: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME
著者Gassner, N.C, Baase, W.A, Mooers, B.H, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.W.
登録日2002-01-28
公開日2003-06-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability
BIOPHYS.CHEM., 100, 2003
210L
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PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
分子名称: 2-HYDROXYETHYL DISULFIDE, T4 LYSOZYME
著者Vetter, I.R, Baase, W.A, Heinz, D.W, Xiong, J.-P, Snow, S, Matthews, B.W.
登録日1996-09-23
公開日1996-12-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme.
Protein Sci., 5, 1996
214L
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PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
分子名称: T4 LYSOZYME
著者Vetter, I.R, Baase, W.A, Heinz, D.W, Xiong, J.-P, Snow, S, Matthews, B.W.
登録日1996-09-23
公開日1996-12-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme.
Protein Sci., 5, 1996
148L
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A COVALENT ENZYME-SUBSTRATE INTERMEDIATE WITH SACCHARIDE DISTORTION IN A MUTANT T4 LYSOZYME
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-N-acetyl-alpha-muramic acid, BETA-MERCAPTOETHANOL, SUBSTRATE CLEAVED FROM CELL WALL OF ESCHERICHIA COLI, ...
著者Kuroki, R, Weaver, L.H, Matthews, B.W.
登録日1993-10-27
公開日1994-04-30
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A covalent enzyme-substrate intermediate with saccharide distortion in a mutant T4 lysozyme.
Science, 262, 1993
172L
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PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
分子名称: BETA-MERCAPTOETHANOL, T4 LYSOZYME
著者Weaver, L.H, Zhang, X.-J, Matthews, B.W.
登録日1995-03-24
公開日1995-07-10
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Protein flexibility and adaptability seen in 25 crystal forms of T4 lysozyme.
J.Mol.Biol., 250, 1995
1OWZ
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T4 Lysozyme Cavity Mutant L99A/M102Q Bound With 4-FluoroPhenEthyl Alcohol
分子名称: 4-FLUOROPHENETHYL ALCOHOL, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
著者Wei, B.Q, Baase, W.A, Weaver, L.H, Matthews, B.W, Shoichet, B.K.
登録日2003-03-31
公開日2004-04-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Testing a Flexible-receptor Docking Algorithm in a Model Binding Site
J.Mol.Biol., 337, 2004
1OWY
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T4 Lysozyme Cavity Mutant L99A/M102Q Bound With 2-Propyl-Aniline
分子名称: 2-PROPYL-ANILINE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
著者Wei, B.Q, Baase, W.A, Weaver, L.H, Matthews, B.W, Shoichet, B.K.
登録日2003-03-31
公開日2004-04-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Testing a Flexible-receptor Docking Algorithm in a Model Binding Site
J.Mol.Biol., 337, 2004

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