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PDB: 49 件
2H5C
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BU of 2h5c by Molmil
0.82A resolution crystal structure of alpha-lytic protease at pH 5
分子名称: ALPHA-LYTIC PROTEASE, GLYCEROL, SULFATE ION
著者Fuhrmann, C.N, Daugherty, M.D, Agard, D.A.
登録日2006-05-25
公開日2006-09-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (0.82 Å)
主引用文献Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis
J.Am.Chem.Soc., 128, 2006
1SSX
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BU of 1ssx by Molmil
0.83A resolution crystal structure of alpha-lytic protease at pH 8
分子名称: Alpha-lytic protease, GLYCEROL, SULFATE ION
著者Fuhrmann, C.N, Agard, D.A.
登録日2004-03-24
公開日2004-05-04
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (0.83 Å)
主引用文献The 0.83A Resolution Crystal Structure of alpha-Lytic Protease Reveals the Detailed Structure of the Active Site and Identifies a Source of Conformational Strain.
J.Mol.Biol., 338, 2004
2H5D
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BU of 2h5d by Molmil
0.9A resolution crystal structure of alpha-lytic protease complexed with a transition state analogue, MeOSuc-Ala-Ala-Pro-Val boronic acid
分子名称: ALPHA-LYTIC PROTEASE, GLYCEROL, MEOSUC-ALA-ALA-PRO-ALA BORONIC ACID INHIBITOR, ...
著者Fuhrmann, C.N, Agard, D.A.
登録日2006-05-25
公開日2006-09-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (0.9 Å)
主引用文献Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis
J.Am.Chem.Soc., 128, 2006
3M7U
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BU of 3m7u by Molmil
Crystal Structure of Alpha-Lytic Protease SB1+2 R64A/E182Q Mutant
分子名称: Alpha-lytic protease, SELF-PROTEOLYSIS PRODUCT (RESIDUES 184-187), SULFATE ION
著者Agard, D.A, Erciyas Bailey, F.P, Waddling, C.A.
登録日2010-03-17
公開日2011-02-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Quantifying protein unfolding cooperativity with acid sensitive probes: Interdomain salt bridge contributions to unfolding cooperativity are combined efficiently in alpha-Lytic Protease
To be Published
3URD
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BU of 3urd by Molmil
T181A mutant of alpha-Lytic Protease
分子名称: Alpha-lytic protease, GLYCEROL, SULFATE ION
著者Kelch, B.A, Agard, D.A.
登録日2011-11-22
公開日2012-05-23
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (1.08 Å)
主引用文献Functional modulation of a protein folding landscape via side-chain distortion.
Proc.Natl.Acad.Sci.USA, 109, 2012
3URC
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BU of 3urc by Molmil
T181G mutant of alpha-Lytic Protease
分子名称: Alpha-lytic protease, GLYCEROL, SULFATE ION
著者Kelch, B.A, Agard, D.A.
登録日2011-11-22
公開日2012-05-23
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Functional modulation of a protein folding landscape via side-chain distortion.
Proc.Natl.Acad.Sci.USA, 109, 2012
1QQ4
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BU of 1qq4 by Molmil
CRYSTAL STRUCTURE OF AN ALPHA-LYTIC PROTEASE MUTANT WITH ACCELERATED FOLDING KINETICS, R102H/G134S
分子名称: ALPHA-LYTIC PROTEASE, GLYCEROL, SULFATE ION
著者Derman, A.I, Mau, T, Agard, D.A.
登録日1999-06-10
公開日1999-06-15
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献A Genetic Screen That Targets Specifically the Folding Transition State of Alpha-Lytic Protease
To be Published, 1999
1QRW
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BU of 1qrw by Molmil
CRYSTAL STRUCTURE OF AN ALPHA-LYTIC PROTEASE MUTANT WITH ACCELERATED FOLDING KINETICS, R102H/G134S, PH 8
分子名称: ALHPA-LYTIC PROTEASE, GLYCEROL, SULFATE ION
著者Derman, A.I, Mau, T, Agard, D.A.
登録日1999-06-16
公開日1999-06-18
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献A Genetic Screen That Targets Specifically the Folding Transition State of Alpha-Lytic Protease
To be Published, 1999
3QGJ
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BU of 3qgj by Molmil
1.3A Structure of alpha-Lytic Protease Bound to Ac-AlaAlaPro-Alanal
分子名称: 1,2-ETHANEDIOL, Ac-AlaAlaPro-Alanal peptide, Alpha-lytic protease, ...
著者Everill, P, Meinke, G, Bohm, A, Bachovchin, W.
登録日2011-01-24
公開日2012-02-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Substrate Binding Defines Ser195 Position in the Catalytic Triad of Serine Proteases, Not His57 protonation
To be Published
3URE
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BU of 3ure by Molmil
Repack mutant (T181I, W199L, Q210I) of alpha-Lytic Protease
分子名称: Alpha-lytic protease, SULFATE ION
著者Kelch, B.A, Agard, D.A.
登録日2011-11-22
公開日2012-05-23
最終更新日2012-07-18
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Functional modulation of a protein folding landscape via side-chain distortion.
Proc.Natl.Acad.Sci.USA, 109, 2012
1TAL
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BU of 1tal by Molmil
ALPHA-LYTIC PROTEASE AT 120 K (SINGLE STRUCTURE MODEL)
分子名称: ALPHA-LYTIC PROTEASE, SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE
著者Rader, S.D, Agard, D.A.
登録日1996-10-30
公開日1997-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution.
Protein Sci., 6, 1997
2ULL
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BU of 2ull by Molmil
MULTIPLE CONFORMATION STRUCTURE OF ALPHA-LYTIC PROTEASE AT 120 K
分子名称: ALPHA-LYTIC PROTEASE, SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE
著者Rader, S.D, Agard, D.A.
登録日1996-11-26
公開日1997-07-07
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution.
Protein Sci., 6, 1997
3M7T
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BU of 3m7t by Molmil
Crystal Structure of Alpha-Lytic Protease SB2+3 E8A/R105S Mutant
分子名称: Alpha-lytic protease, GLYCEROL, SULFATE ION
著者Agard, D.A, Erciyas Bailey, F.P, Waddling, C.A.
登録日2010-03-17
公開日2011-02-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Quantifying protein unfolding cooperativity with acid sensitive probes: Interdomain salt bridge contributions to unfolding cooperativity are combined efficiently in alpha-Lytic Protease
To be Published
1QRX
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BU of 1qrx by Molmil
CRYSTAL STRUCTURE OF WILD-TYPE ALPHA-LYTIC PROTEASE AT 1.6 A, PH 5.14
分子名称: ALPHA-LYTIC PROTEASE, GLYCEROL, SULFATE ION
著者Derman, A.I, Mau, T, Agard, D.A.
登録日1999-06-16
公開日1999-06-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A Genetic Screen That Targets Specifically the Folding Transition State of Alpha-Lytic Protease
To be Published, 1999
2ALP
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BU of 2alp by Molmil
REFINED STRUCTURE OF ALPHA-LYTIC PROTEASE AT 1.7 ANGSTROMS RESOLUTION. ANALYSIS OF HYDROGEN BONDING AND SOLVENT STRUCTURE
分子名称: ALPHA-LYTIC PROTEASE, SULFATE ION
著者Fujinaga, M, Delbaere, L.T.J, Brayer, G.D, James, M.N.G.
登録日1985-03-07
公開日1985-07-17
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Refined structure of alpha-lytic protease at 1.7 A resolution. Analysis of hydrogen bonding and solvent structure.
J.Mol.Biol., 184, 1985
3PRO
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BU of 3pro by Molmil
ALPHA-LYTIC PROTEASE COMPLEXED WITH C-TERMINAL TRUNCATED PRO REGION
分子名称: 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, ALPHA-LYTIC PROTEASE
著者Sauter, N.K, Mau, T, Rader, S.D, Agard, D.A.
登録日1998-08-26
公開日1999-04-27
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of alpha-lytic protease complexed with its pro region.
Nat.Struct.Biol., 5, 1998
1P12
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BU of 1p12 by Molmil
CRYSTAL STRUCTURES OF ALPHA-LYTIC PROTEASE COMPLEXES WITH IRREVERSIBLY BOUND PHOSPHONATE ESTERS
分子名称: ALPHA-LYTIC PROTEASE, PHOSPHONATE ESTER INHIBITOR, SULFATE ION
著者Bone, R, Agard, D.A.
登録日1990-10-26
公開日1993-01-15
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of alpha-lytic protease complexes with irreversibly bound phosphonate esters.
Biochemistry, 30, 1991
1P11
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BU of 1p11 by Molmil
CRYSTAL STRUCTURES OF ALPHA-LYTIC PROTEASE COMPLEXES WITH IRREVERSIBLY BOUND PHOSPHONATE ESTERS
分子名称: ALPHA-LYTIC PROTEASE, PHOSPHONATE ESTER INHIBITOR A, PHOSPHONATE ESTER INHIBITOR B(TRANSITION STATE), ...
著者Bone, R, Agard, D.A.
登録日1990-10-26
公開日1993-01-15
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Crystal structures of alpha-lytic protease complexes with irreversibly bound phosphonate esters.
Biochemistry, 30, 1991
1P01
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BU of 1p01 by Molmil
Serine protease mechanism. structure of an inhibitory complex oF ALPHA-LYTIC Protease and a tightly bound peptide boronic acid
分子名称: ALPHA-LYTIC PROTEASE, N-(tert-butoxycarbonyl)-L-alanyl-N-[(1R)-1-(dihydroxyboranyl)-2-methylpropyl]-L-prolinamide, SULFATE ION
著者Bone, R, Agard, D.A.
登録日1989-04-24
公開日1990-04-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Serine protease mechanism: structure of an inhibitory complex of alpha-lytic protease and a tightly bound peptide boronic acid.
Biochemistry, 26, 1987
1P02
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BU of 1p02 by Molmil
STRUCTURE ANALYSIS OF SPECIFICITY. ALPHA-LYTIC PROTEASE COMPLEXES WITH ANALOGUES OF REACTION INTERMEDIATES
分子名称: ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID INHIBITOR, SULFATE ION
著者Bone, R, Agard, D.A.
登録日1989-04-24
公開日1990-04-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates.
Biochemistry, 28, 1989
1GBJ
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BU of 1gbj by Molmil
ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA
分子名称: ALPHA-LYTIC PROTEASE, SULFATE ION
著者Mace, J.E, Agard, D.A.
登録日1995-09-06
公開日1996-01-29
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity.
J.Mol.Biol., 254, 1995
7LPR
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BU of 7lpr by Molmil
STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
分子名称: ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID INHIBITOR, SULFATE ION
著者Fujishige, A, Bone, R, Agard, D.A.
登録日1991-08-05
公開日1993-01-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural basis for broad specificity in alpha-lytic protease mutants.
Biochemistry, 30, 1991
1P05
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BU of 1p05 by Molmil
STRUCTURE ANALYSIS OF SPECIFICITY. ALPHA-LYTIC PROTEASE COMPLEXES WITH ANALOGUES OF REACTION INTERMEDIATES
分子名称: ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-NORLEUCINE BORONIC ACID INHIBITOR, SULFATE ION
著者Bone, R, Agard, D.A.
登録日1989-04-24
公開日1990-04-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates.
Biochemistry, 28, 1989
1BOQ
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BU of 1boq by Molmil
PRO REGION C-TERMINUS: PROTEASE ACTIVE SITE INTERACTIONS ARE CRITICAL IN CATALYZING THE FOLDING OF ALPHA-LYTIC PROTEASE
分子名称: PROTEIN (ALPHA-LYTIC PROTEASE), SULFATE ION
著者Peters, R.J, Shiau, A.K, Sohl, J.L, Anderson, D.E, Tang, G, Silen, J.L, Agard, D.A.
登録日1998-08-05
公開日1998-08-12
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Pro region C-terminus:protease active site interactions are critical in catalyzing the folding of alpha-lytic protease.
Biochemistry, 37, 1998
6LPR
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BU of 6lpr by Molmil
STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
分子名称: ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-NORLEUCINE BORONIC ACID INHIBITOR, SULFATE ION
著者Bone, R, Agard, D.A.
登録日1991-08-05
公開日1993-01-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for broad specificity in alpha-lytic protease mutants.
Biochemistry, 30, 1991

 

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