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PDB: 8 件
1VZO
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BU of 1vzo by Molmil
The structure of the N-terminal kinase domain of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein
分子名称: BETA-MERCAPTOETHANOL, RIBOSOMAL PROTEIN S6 KINASE ALPHA 5, SULFATE ION
著者Smith, K.J, Carter, P.S, Bridges, A, Horrocks, P, Lewis, C, Pettman, G, Clarke, A, Brown, M, Hughes, J, Wilkinson, M, Bax, B, Reith, A.
登録日2004-05-21
公開日2004-06-11
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Structure of Msk1 Reveals a Novel Autoinhibitory Conformation for a Dual Kinase Protein
Structure, 12, 2004
3KN6
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BU of 3kn6 by Molmil
Crystal structure of the C-terminal kinase domain of MSK1
分子名称: Ribosomal protein S6 kinase alpha-5
著者D'Angelo, I, Malakhova, M, Dong, Z.
登録日2009-11-12
公開日2010-04-21
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.
J.Mol.Biol., 399, 2010
3KN5
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BU of 3kn5 by Molmil
Crystal structure of the C-terminal kinase domain of msk1 in complex with AMP-PNP
分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-5
著者D'Angelo, I, Malakhova, M, Dong, Z.
登録日2009-11-12
公開日2010-04-21
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.
J.Mol.Biol., 399, 2010
7UP6
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BU of 7up6 by Molmil
Crystal structure of C-terminal domain of MSK1 in complex with in covalently bound literature RSK2 inhibitor pyrrolopyrimidine cyanoacrylamide compound 25 (co-crystal)
分子名称: (E)-3-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-cyanoacrylamide bound form, OXAMIC ACID, Ribosomal protein S6 kinase alpha-5
著者Yano, J.K, Abendroth, J, Hall, A.
登録日2022-04-14
公開日2022-08-31
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1.
Acs Med.Chem.Lett., 13, 2022
7UP5
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BU of 7up5 by Molmil
Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound pyrrolopyrimidine compound 23 (co-crystal)
分子名称: (2M)-6-chloro-2-(5H-pyrrolo[3,2-d]pyrimidin-5-yl)pyridine-3-carbonitrile, IODIDE ION, Ribosomal protein S6 kinase alpha-5
著者Yano, J.K, Edwards, T.E, Hall, A.
登録日2022-04-14
公開日2022-07-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1.
Acs Med.Chem.Lett., 13, 2022
7UP7
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BU of 7up7 by Molmil
Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound with literature RSK2 inhibitor indazole cyanoacrylamide compound 26 (soak)
分子名称: (2S)-2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]propanamide, Ribosomal protein S6 kinase alpha-5
著者Yano, J.K, Abendroth, J, Hall, A.
登録日2022-04-14
公開日2022-07-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1.
Acs Med.Chem.Lett., 13, 2022
7UP8
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BU of 7up8 by Molmil
Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound pyrrolopyrimidine compound 27 (co-crystal)
分子名称: (5M)-5-(5-bromo-2-chloropyrimidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine, Ribosomal protein S6 kinase alpha-5
著者Yano, J.K, Abendroth, J, Hall, A.
登録日2022-04-14
公開日2022-07-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1.
Acs Med.Chem.Lett., 13, 2022
7UP4
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BU of 7up4 by Molmil
Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound pyrrolopyrimidine compound 20 (co-crystal)
分子名称: (5M)-5-(2,5-dichloropyrimidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine, Ribosomal protein S6 kinase alpha-5
著者Yano, J.K, Abendroth, J, Hall, A.
登録日2022-04-14
公開日2022-07-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1.
Acs Med.Chem.Lett., 13, 2022

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件を2024-07-10に公開中

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