2WW6
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![BU of 2ww6 by Molmil](/molmil-images/mine/2ww6) | foldon containing D-amino acids in turn positions | 分子名称: | FIBRITIN, TETRAETHYLENE GLYCOL | 著者 | Eckhardt, B, Grosse, W, Essen, L.-O, Geyer, A. | 登録日 | 2009-10-22 | 公開日 | 2010-09-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (0.98 Å) | 主引用文献 | Structural Characterization of a Beta-Turn Mimic within a Protein-Protein Interface. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WW7
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6OJ7
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3KPE
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![BU of 3kpe by Molmil](/molmil-images/mine/3kpe) | Solution structure of the respiratory syncytial virus (RSV)six-helix bundle complexed with TMC353121, a small-moleucule inhibitor of RSV | 分子名称: | 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol, Fusion glycoprotein F0, TETRAETHYLENE GLYCOL | 著者 | Roymans, D, De Bondt, H, Arnoult, E, Cummings, M.D, Van Vlijmen, H, Andries, K. | 登録日 | 2009-11-16 | 公開日 | 2009-12-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein. Proc.Natl.Acad.Sci.USA, 107, 2010
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3O41
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![BU of 3o41 by Molmil](/molmil-images/mine/3o41) | Crystal Structure of 101F Fab Bound to 15-mer Peptide Epitope | 分子名称: | Fusion glycoprotein F1, Mouse monoclonal antibody 101F Fab heavy chain, Mouse monoclonal antibody 101F Fab light chain, ... | 著者 | McLellan, J.S, Chen, M, Chang, J.S, Yang, Y, Kim, A, Graham, B.S, Kwong, P.D. | 登録日 | 2010-07-26 | 公開日 | 2010-10-13 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F. J.Virol., 84, 2010
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6VKE
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![BU of 6vke by Molmil](/molmil-images/mine/6vke) | Crystal Structure of Inhibitor JNJ-40012665 in Complex with Prefusion RSV F Glycoprotein | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 4-(5-chloro-2-{[1-(3,4-dimethoxyphenyl)-2-oxo-1,2-dihydro-3H-imidazo[4,5-c]pyridin-3-yl]methyl}-1H-indol-1-yl)butanenitrile, CHLORIDE ION, ... | 著者 | McLellan, J.S. | 登録日 | 2020-01-20 | 公開日 | 2020-05-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus. J.Med.Chem., 63, 2020
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7LVW
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![BU of 7lvw by Molmil](/molmil-images/mine/7lvw) | Structure of RSV F in Complex with VHH Cl184 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, F-VHH-Cl184, ... | 著者 | Hsieh, C.-L, McLellan, J.S. | 登録日 | 2021-02-26 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A vulnerable, membrane-proximal site in human respiratory syncytial virus F revealed by a prefusion-specific single-domain antibody. J.Virol., 95, 2021
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6NTX
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8DG9
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8PHI
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![BU of 8phi by Molmil](/molmil-images/mine/8phi) | Crystal structure of prefusion-stabilized RSV F Variant DS-Cav1 in complex with Lonafarnib | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, CALCIUM ION, ... | 著者 | Rajak, M, Krey, T. | 登録日 | 2023-06-19 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.289 Å) | 主引用文献 | Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor. Nat Commun, 15, 2024
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5EA4
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![BU of 5ea4 by Molmil](/molmil-images/mine/5ea4) | Crystal Structure of Inhibitor JNJ-49153390 in Complex with Prefusion RSV F Glycoprotein | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 3-[[5-bromanyl-1-(3-methylsulfonylpropyl)benzimidazol-2-yl]methyl]-1-cyclopropyl-imidazo[4,5-c]pyridin-2-one, Fusion glycoprotein F0, ... | 著者 | Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P. | 登録日 | 2015-10-15 | 公開日 | 2015-12-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat.Chem.Biol., 12, 2016
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5C69
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4MMS
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![BU of 4mms by Molmil](/molmil-images/mine/4mms) | Crystal Structure of Prefusion-stabilized RSV F Variant Cav1 at pH 5.5 | 分子名称: | Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2, SULFATE ION | 著者 | Mclellan, J.S, Joyce, M.G, Stewart-Jones, G.B.E, Sastry, M, Yang, Y, Graham, B.S, Kwong, P.D. | 登録日 | 2013-09-09 | 公開日 | 2013-11-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.397 Å) | 主引用文献 | Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus. Science, 342, 2013
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5C6B
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8E15
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![BU of 8e15 by Molmil](/molmil-images/mine/8e15) | A computationally stabilized hMPV F protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, F1 protein with Fibritin peptide, F2 protein, ... | 著者 | Huang, J, Gonzalez, K, Mousa, J, Strauch, E. | 登録日 | 2022-08-09 | 公開日 | 2023-04-12 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | A general computational design strategy for stabilizing viral class I fusion proteins. Nat Commun, 15, 2024
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8DZW
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![BU of 8dzw by Molmil](/molmil-images/mine/8dzw) | RSV F trimer bound to RSV-199 Fab | 分子名称: | RSV fusion protein, RSV-199 Heavy chain protein, RSV-199 Light chain protein | 著者 | Wen, X, Jardetzky, T.S. | 登録日 | 2022-08-08 | 公開日 | 2023-08-16 | 最終更新日 | 2023-08-23 | 実験手法 | ELECTRON MICROSCOPY (2.46 Å) | 主引用文献 | Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode. Cell Host Microbe, 31, 2023
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6VKD
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![BU of 6vkd by Molmil](/molmil-images/mine/6vkd) | Crystal Structure of Inhibitor JNJ-36689282 in Complex with Prefusion RSV F Glycoprotein | 分子名称: | 1-cyclopropyl-3-({1-[3-(methylsulfonyl)propyl]-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, CHLORIDE ION, Prefusion RSV F (DS-Cav1), ... | 著者 | McLellan, J.S. | 登録日 | 2020-01-20 | 公開日 | 2020-05-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus. J.Med.Chem., 63, 2020
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5KWW
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![BU of 5kww by Molmil](/molmil-images/mine/5kww) | Crystal Structure of Inhibitor JNJ-53718678 In Complex with Prefusion RSV F Glycoprotein | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[[5-chloranyl-1-(3-methylsulfonylpropyl)indol-2-yl]methyl]-1-[2,2,2-tris(fluoranyl)ethyl]imidazo[4,5-c]pyridin-2-one, ... | 著者 | McLellan, J.S, Battles, M.B, Arnoult, E, Roymans, D, Langedijk, J.P. | 登録日 | 2016-07-19 | 公開日 | 2017-08-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor. Nat Commun, 8, 2017
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5K6F
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![BU of 5k6f by Molmil](/molmil-images/mine/5k6f) | Crystal structure of prefusion-stabilized RSV F single-chain 9-19 DS-Cav1 variant. | 分子名称: | Fusion glycoprotein F0 | 著者 | Joyce, M.G, Zhang, B, Lai, Y.T, Mascola, J.R, Kwong, P.D. | 登録日 | 2016-05-24 | 公開日 | 2016-08-10 | 最終更新日 | 2016-09-21 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV. Nat.Struct.Mol.Biol., 23, 2016
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5EA8
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![BU of 5ea8 by Molmil](/molmil-images/mine/5ea8) | Crystal Structure of Prefusion RSV F Glycoprotein Fusion Inhibitor Resistance Mutant D489Y | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, D(-)-TARTARIC ACID, Fusion glycoprotein F0, ... | 著者 | Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P. | 登録日 | 2015-10-15 | 公開日 | 2015-12-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat.Chem.Biol., 12, 2016
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6VKC
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![BU of 6vkc by Molmil](/molmil-images/mine/6vkc) | Crystal Structure of Inhibitor JNJ-36811054 in Complex with Prefusion RSV F Glycoprotein | 分子名称: | 3-{[5-chloro-1-(4,4,4-trifluorobutyl)-1H-imidazo[4,5-b]pyridin-2-yl]methyl}-1-cyclopropyl-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, CHLORIDE ION, D(-)-TARTARIC ACID, ... | 著者 | McLellan, J.S. | 登録日 | 2020-01-20 | 公開日 | 2020-05-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus. J.Med.Chem., 63, 2020
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6EAK
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5K6H
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4CCF
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5TDG
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