9ETR
 
 | | Crystal structure of PARP1 catalytic domain bound to AZD9574 | | 分子名称: | 6-fluoranyl-5-[4-[(5-fluoranyl-2-methyl-3-oxidanylidene-4~{H}-quinoxalin-6-yl)methyl]piperazin-1-yl]-~{N}-methyl-pyridine-2-carboxamide, Poly [ADP-ribose] polymerase 1, processed C-terminus, ... | | 著者 | Schimpl, M. | | 登録日 | 2024-03-26 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-01-08 | | 実験手法 | X-RAY DIFFRACTION (1.822 Å) | | 主引用文献 | Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor.
J.Med.Chem., 67, 2024
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9ETQ
 | | Crystal structure of PARP1 catalytic domain bound to AZD5305 (SARUPARIB) | | 分子名称: | 5-[4-[(7-ethyl-6-oxidanylidene-5~{H}-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl]-~{N}-methyl-pyridine-2-carboxamide, Poly [ADP-ribose] polymerase 1, SULFATE ION | | 著者 | Schimpl, M. | | 登録日 | 2024-03-26 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-01-08 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor.
J.Med.Chem., 67, 2024
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