PDB クエリの検索結果 - 日本蛋白質構造データバンク

PDB: 2 件

PRMT5 complex bound to covalent PBM inhibitor BRD6711
分子名称:	2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-sulfamoylphenyl)acetamide, CHLORIDE ION, GLYCEROL, ...
著者	McMillan, B.J, McKinney, D.C.
登録日	2019-11-19
公開日	2020-11-25
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (1.88 Å)
主引用文献	Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J.Med.Chem., 64, 2021

CryoEM structure of PRMT5 bound to covalent PBM-site inhibitor BRD-6988
分子名称:	2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-{[2-(pyridin-2-yl)ethyl]sulfamoyl}phenyl)acetamide, Methylosome protein 50, Protein arginine N-methyltransferase 5
著者	McMillan, B.J, McKinney, D.C, Timm, D.E.
登録日	2021-03-10
公開日	2021-03-17
最終更新日	2021-08-25
実験手法	ELECTRON MICROSCOPY (2.39 Å)
主引用文献	Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J.Med.Chem., 64, 2021