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PDB: 5 件

9BRE
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BU of 9bre by Molmil
Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL019-21
分子名称: (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[(4-{[(2S)-2-(furan-2-yl)-2-hydroxyacetyl]amino}-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5
著者Chen, Y, Tesmer, J.J.G.
登録日2024-05-11
公開日2025-02-19
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors.
Eur.J.Med.Chem., 282, 2025
9BRJ
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BU of 9brj by Molmil
Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL093-22
分子名称: (4S)-N-{5-[(Z)-(5-{[(1R)-1-(4-fluorophenyl)ethyl]carbamoyl}-2-oxo-2,7-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-yl}-2-methylimidazo[1,2-a]pyridine-3-carboxamide, G protein-coupled receptor kinase 5
著者Chen, Y, Tesmer, J.J.G.
登録日2024-05-11
公開日2025-02-19
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors.
Eur.J.Med.Chem., 282, 2025
9BRH
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BU of 9brh by Molmil
Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL056-21
分子名称: (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-({4-[(furan-3-carbonyl)amino]-3,5-dimethyl-1H-pyrrol-2-yl}methylidene)-2-oxo-3,7-dihydro-2H-indole-5-carboxamide, G protein-coupled receptor kinase 5
著者Chen, Y, Tesmer, J.J.G.
登録日2024-05-11
公開日2025-02-19
実験手法X-RAY DIFFRACTION (3.69 Å)
主引用文献Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors.
Eur.J.Med.Chem., 282, 2025
9BRI
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BU of 9bri by Molmil
Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL064-22
分子名称: (3Z)-3-[(3,5-dimethyl-4-{[(2S)-5-oxooxolane-2-carbonyl]amino}-1H-pyrrol-2-yl)methylidene]-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5
著者Chen, Y, Tesmer, J.J.G.
登録日2024-05-11
公開日2025-02-19
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors.
Eur.J.Med.Chem., 282, 2025
9BRG
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BU of 9brg by Molmil
Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL055-22
分子名称: (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-({4-[(furan-2-carbonyl)amino]-3,5-dimethyl-1H-pyrrol-2-yl}methylidene)-2-oxo-3,7-dihydro-2H-indole-5-carboxamide, G protein-coupled receptor kinase 5
著者Chen, Y, Tesmer, J.J.G.
登録日2024-05-11
公開日2025-02-19
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors.
Eur.J.Med.Chem., 282, 2025

239149

件を2025-07-23に公開中

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