PDB クエリの検索結果 - 日本蛋白質構造データバンク

PDB: 3 件

Crystal structure of human KRAS G12C covalently bound with Taiho WO2020/085493A1 compound 6
分子名称:	2-{[(5-tert-butyl-6-chloro-1H-indazol-3-yl)amino]methyl}-4-chloro-1-methyl-N-(1-propanoylazetidin-3-yl)-1H-imidazole-5-carboxamide, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ...
著者	Mohr, C.
登録日	2022-07-11
公開日	2022-08-17
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.23 Å)
主引用文献	Modeling receptor flexibility in the structure-based design of KRAS G12C inhibitors. J.Comput.Aided Mol.Des., 36, 2022

Crystal structure of human KRAS G12C covalently bound with Araxes WO2020/028706A1 compound I-1
分子名称:	(4P)-4-(5-methyl-1H-indazol-4-yl)-6-(2-propanoyl-2,6-diazaspiro[3.4]octan-6-yl)-2-(pyrrolidin-1-yl)pyrimidine-5-carbonitrile, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
著者	Mohr, C.
登録日	2022-07-11
公開日	2022-08-17
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Modeling receptor flexibility in the structure-based design of KRAS G12C inhibitors. J.Comput.Aided Mol.Des., 36, 2022

Crystal structure of human KRAS G12C covalently bound with AstraZeneca WO2020/178282A1 compound 76
分子名称:	1-[(5S,9P,12aR)-9-(2-chloro-6-hydroxyphenyl)-8-ethynyl-10-fluoro-3,4,12,12a-tetrahydro-6H-pyrazino[2,1-c][1,4]benzoxazepin-2(1H)-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ...
著者	Mohr, C.
登録日	2022-07-11
公開日	2022-08-17
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.81 Å)
主引用文献	Modeling receptor flexibility in the structure-based design of KRAS G12C inhibitors. J.Comput.Aided Mol.Des., 36, 2022