8JF4
| The crystal structure of human AURKA kinase domain in complex with AURKA-compound 9 | Descriptor: | 2-[4-[4-[bis(oxidanylidene)-$l^5-sulfanyl]oxyphenyl]carbonylpiperazin-1-yl]-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-N-prop-2-ynyl-pyrimidine-4-carboxamide, Aurora kinase A | Authors: | Zhu, C.J. | Deposit date: | 2023-05-17 | Release date: | 2024-02-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.89288354 Å) | Cite: | Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development. Angew.Chem.Int.Ed.Engl., 63, 2024
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8JMX
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7PYK
| CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA (NusA elongation complex in more-swiveled conformation) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-10 | Release date: | 2022-03-23 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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7Q0J
| RNA polymerase elongation complex in more-swiveled conformation | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-15 | Release date: | 2022-03-23 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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7PY0
| CryoEM structure of E.coli RNA polymerase elongation complex bound to NusG (NusG-EC in more-swiveled conformation) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-08 | Release date: | 2022-03-23 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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7PY7
| CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA and NusG (NusA and NusG elongation complex in more-swiveled conformation) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-09 | Release date: | 2022-03-23 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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7PY8
| CryoEM structure of E.coli RNA polymerase elongation complex bound to NusG (NusG-EC in less-swiveled conformation) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-09 | Release date: | 2022-03-23 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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7PY5
| CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA and NusG (the consensus NusA-NusG-EC) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-09 | Release date: | 2022-03-23 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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7PY3
| CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA (the consensus NusA-EC) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-08 | Release date: | 2022-03-23 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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7Q0K
| RNA polymerase elongation complex in less-swiveled conformation | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-15 | Release date: | 2022-03-23 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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7PY6
| CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA and NusG (NusA and NusG elongation complex in less-swiveled conformation) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-09 | Release date: | 2022-03-23 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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7PY1
| CryoEM structure of E.coli RNA polymerase elongation complex bound to NusG (the consensus NusG-EC) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-08 | Release date: | 2022-03-23 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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7PYJ
| CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA (NusA elongation complex in less-swiveled conformation) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-10 | Release date: | 2022-03-23 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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4RXO
| The structure of GTP-bound SAMHD1 | Descriptor: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, ... | Authors: | Zhu, C.F, Wei, W, Peng, X, Dong, Y.H, Gong, Y, Yu, X.F. | Deposit date: | 2014-12-11 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D, 71, 2015
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4RXS
| The structure of GTP-dTTP-bound SAMHD1 | Descriptor: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Zhu, C.F, Wei, W, Peng, X, Dong, Y.H, Gong, Y, Yu, X.F. | Deposit date: | 2014-12-11 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D, 71, 2015
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4RXR
| The structure of GTP-dCTP-bound SAMHD1 | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhu, C.F, Wei, W, Peng, X, Dong, Y.H, Gong, Y, Yu, X.F. | Deposit date: | 2014-12-11 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.117 Å) | Cite: | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D, 71, 2015
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4RXQ
| The structure of GTP-dUTP-bound SAMHD1 | Descriptor: | DEOXYURIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhu, C.F, Wei, W, Peng, X, Dong, Y.H, Gong, Y, Yu, X.F. | Deposit date: | 2014-12-11 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D, 71, 2015
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4RXP
| The structure of GTP-dATP-bound SAMHD1 | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhu, C.F, Wei, W, Peng, X, Dong, Y.H, Gong, Y, Yu, X.F. | Deposit date: | 2014-12-11 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D, 71, 2015
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8JG8
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6CFE
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5ITX
| Crystal Structure of Human NEIL1(P2G R242K) bound to duplex DNA containing Thymine Glycol | Descriptor: | DNA (26-MER), Endonuclease 8-like 1 | Authors: | Zhu, C, Lu, L, Zhang, J, Yue, Z, Song, J, Zong, S, Liu, M, Stovicek, O, Gao, Y, Yi, C. | Deposit date: | 2016-03-17 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair Proc.Natl.Acad.Sci.USA, 113, 2016
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4NID
| Crystal structure of AlkB protein with cofactors bound to dsDNA containing m6A | Descriptor: | 2-OXOGLUTARIC ACID, 5'-D(*AP*AP*CP*GP*GP*TP*AP*TP*TP*AP*CP*CP*T)-3', 5'-D(*TP*AP*GP*GP*TP*AP*AP*(6MA)P*AP*CP*CP*GP*T)-3', ... | Authors: | Zhu, C.X, Yi, C.Q. | Deposit date: | 2013-11-06 | Release date: | 2014-04-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Switching Demethylation Activities between AlkB Family RNA/DNA Demethylases through Exchange of Active-Site Residues. Angew.Chem.Int.Ed.Engl., 53, 2014
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5ITU
| Crystal Structure of Human NEIL1(242K) bound to duplex DNA containing THF | Descriptor: | DNA (5'-D(*CP*GP*TP*CP*CP*AP*CP*GP*TP*CP*TP*AP*C)-3'), DNA (5'-D(*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*G)-3'), Endonuclease 8-like 1 | Authors: | Zhu, C, Lu, L, Zhang, J, Yue, Z, Song, J, Zong, S, Liu, M, Stovicek, O, Gao, Y, Yi, C. | Deposit date: | 2016-03-17 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair Proc.Natl.Acad.Sci.USA, 113, 2016
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5ITT
| Crystal Structure of Human NEIL1 bound to duplex DNA containing THF | Descriptor: | DNA (26-MER), Endonuclease 8-like 1, GLYCEROL | Authors: | Zhu, C, Lu, L, Zhang, J, Yue, Z, Song, J, Zong, S, Liu, M, Stovicek, O, Gao, Y, Yi, C. | Deposit date: | 2016-03-17 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair Proc.Natl.Acad.Sci.USA, 113, 2016
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5ITR
| Crystal Structure of Human NEIL1(P2G) bound to duplex DNA containing THF | Descriptor: | DNA (26-MER), Endonuclease 8-like 1 | Authors: | Zhu, C, Lu, L, Zhang, J, Yue, Z, Song, J, Zong, S, Liu, M, Stovicek, O, Gao, Y, Yi, C. | Deposit date: | 2016-03-17 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair Proc.Natl.Acad.Sci.USA, 113, 2016
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