3I15
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3i15 by Molmil](/molmil-images/mine/3i15) | |
4NQ5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4nq5 by Molmil](/molmil-images/mine/4nq5) | Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 7 complexed with compound CS319 | Descriptor: | (3R,5R,7aS)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, Beta-lactamase 2, POTASSIUM ION, ... | Authors: | Gonzalez, J.M, Gonzalez, M.M, Vila, A.J. | Deposit date: | 2013-11-23 | Release date: | 2014-11-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Inhibition of metallo-lactamases with bicyclic compounds TO BE PUBLISHED
|
|
4NQ4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4nq4 by Molmil](/molmil-images/mine/4nq4) | |
2BG2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2bg2 by Molmil](/molmil-images/mine/2bg2) | Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH4.5 using 20mM ZnSO4 in the buffer. 1mM DTT and 1mM TCEP- HCl were used as reducing agents. Cys221 is reduced. | Descriptor: | BETA-LACTAMASE II, CHLORIDE ION, GLYCEROL, ... | Authors: | Davies, A.M, Rasia, R.M, Vila, A.J, Sutton, B.J, Fabiane, S.M. | Deposit date: | 2004-12-16 | Release date: | 2005-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Effect of Ph on the Active Site of an Arg121Cys Mutant of the Metallo-Beta-Lactamase from Bacillus Cereus: Implications for the Enzyme Mechanism. Biochemistry, 44, 2005
|
|
2BFZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2bfz by Molmil](/molmil-images/mine/2bfz) | Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH4.5 using 20mM ZnSO4 in buffer. 1mM DTT was used as a reducing agent. Cys221 is oxidized. | Descriptor: | AZIDE ION, BETA-LACTAMASE II, GLYCEROL, ... | Authors: | Davies, A.M, Rasia, R.M, Vila, A.J, Sutton, B.J, Fabiane, S.M. | Deposit date: | 2004-12-16 | Release date: | 2005-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Effect of Ph on the Active Site of an Arg121Cys Mutant of the Metallo-Beta-Lactamase from Bacillus Cereus: Implications for the Enzyme Mechanism Biochemistry, 44, 2005
|
|
2BG8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2bg8 by Molmil](/molmil-images/mine/2bg8) | Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH4.5 using 20 Micromolar ZnSO4 in the buffer. 1mM DTT and 1mM TCEP-HCl were used as reducing agents. | Descriptor: | BETA-LACTAMASE II, GLYCEROL, SULFATE ION, ... | Authors: | Davies, A.M, Rasia, R.M, Vila, A.J, Sutton, B.J, Fabiane, S.M. | Deposit date: | 2004-12-17 | Release date: | 2005-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Effect of Ph on the Active Site of an Arg121Cys Mutant of the Metallo-Beta-Lactamase from Bacillus Cereus: Implications for the Enzyme Mechanism Biochemistry, 44, 2005
|
|
2BG7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2bg7 by Molmil](/molmil-images/mine/2bg7) | Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH4.5 using 20 Micromolar ZnSO4 in the buffer. 1mM DTT was used as a reducing agent. Cys221 is oxidized. | Descriptor: | BETA-LACTAMASE II, GLYCEROL, SULFATE ION, ... | Authors: | Davies, A.M, Rasia, R.M, Vila, A.J, Sutton, B.J, Fabiane, S.M. | Deposit date: | 2004-12-17 | Release date: | 2005-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Effect of Ph on the Active Site of an Arg121Cys Mutant of the Metallo-Beta-Lactamase from Bacillus Cereus: Implications for the Enzyme Mechanism Biochemistry, 44, 2005
|
|
2BFK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2bfk by Molmil](/molmil-images/mine/2bfk) | Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH7 using 20mM ZnSO4 in buffer. 1mM DTT was used as a reducing agent | Descriptor: | AZIDE ION, BETA-LACTAMASE II, GLYCEROL, ... | Authors: | Davies, A.M, Rasia, R.M, Vila, A.J, Sutton, B.J, Fabiane, S.M. | Deposit date: | 2004-12-07 | Release date: | 2005-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Effect of Ph on the Active Site of an Arg121Cys Mutant of the Metallo-Beta-Lactamase from Bacillus Cereus: Implications for the Enzyme Mechanism Biochemistry, 44, 2005
|
|
2BG6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2bg6 by Molmil](/molmil-images/mine/2bg6) | Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH5 using 20 Micromolar ZnSO4 in the buffer. 1mM DTT was used as a reducing agent. Cys221 is oxidized. | Descriptor: | AZIDE ION, BETA-LACTAMASE II, GLYCEROL, ... | Authors: | Davies, A.M, Rasia, R.M, Vila, A.J, Sutton, B.J, Fabiane, S.M. | Deposit date: | 2004-12-17 | Release date: | 2005-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Effect of Ph on the Active Site of an Arg121Cys Mutant of the Metallo-Beta-Lactamase from Bacillus Cereus: Implications for the Enzyme Mechanism Biochemistry, 44, 2005
|
|
2BFL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2bfl by Molmil](/molmil-images/mine/2bfl) | Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH5 using 20mM ZnSO4 in buffer. 1mM DTT was used as a reducing agent. | Descriptor: | AZIDE ION, GLYCEROL, Metallo-beta-lactamase type 2, ... | Authors: | Davies, A.M, Rasia, R.M, Vila, A.J, Sutton, B.J, Fabiane, S.M. | Deposit date: | 2004-12-08 | Release date: | 2005-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Effect of Ph on the Active Site of an Arg121Cys Mutant of the Metallo-Beta-Lactamase from Bacillus Cereus: Implications for the Enzyme Mechanism Biochemistry, 44, 2005
|
|
2NYP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2nyp by Molmil](/molmil-images/mine/2nyp) | |
2NZE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2nze by Molmil](/molmil-images/mine/2nze) | Structure of beta-lactamase II from Bacillus cereus. R121H, C221S double mutant. Space group P3121. | Descriptor: | ACETIC ACID, Beta-lactamase II, GLYCEROL, ... | Authors: | Medrano Martin, F.J, Vila, A.J, Gonzalez, J.M. | Deposit date: | 2006-11-23 | Release date: | 2007-05-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Zn2 position in metallo-beta-lactamases is critical for activity: a study on chimeric metal sites on a conserved protein scaffold. J.Mol.Biol., 373, 2007
|
|
2BGA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2bga by Molmil](/molmil-images/mine/2bga) | Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH7 using 20 Micromolar ZnSO4 in the buffer. 1mM DTT was used as a reducing agent. Cys221 is oxidized. | Descriptor: | AZIDE ION, BETA-LACTAMASE II, GLYCEROL, ... | Authors: | Davies, A.M, Rasia, R.M, Vila, A.J, Sutton, B.J, Fabiane, S.M. | Deposit date: | 2004-12-17 | Release date: | 2005-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Effect of Ph on the Active Site of an Arg121Cys Mutant of the Metallo-Beta-Lactamase from Bacillus Cereus: Implications for the Enzyme Mechanism Biochemistry, 44, 2005
|
|
5W8W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5w8w by Molmil](/molmil-images/mine/5w8w) | Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 7 - new refinement | Descriptor: | Metallo-beta-lactamase type 2, SULFATE ION, UNKNOWN ATOM OR ION, ... | Authors: | Gonzalez, J.M, Shabalin, I.G, Raczynska, J.E, Jaskolski, M, Minor, W, Wlodawer, A, Gonzalez, M.M, Vila, A.J. | Deposit date: | 2017-06-22 | Release date: | 2017-07-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | A close look onto structural models and primary ligands of metallo-beta-lactamases. Drug Resist. Updat., 40, 2018
|
|
2QED
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2qed by Molmil](/molmil-images/mine/2qed) | Crystal structure of Salmonella thyphimurium LT2 glyoxalase II | Descriptor: | 1,2-ETHANEDIOL, FE (III) ION, Hydroxyacylglutathione hydrolase | Authors: | Leite, N.R, Campos Bermudez, V.A, Krogh, R, Oliva, G, Soncini, F.C, Vila, A.J. | Deposit date: | 2007-06-25 | Release date: | 2007-10-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Biochemical and Structural Characterization of Salmonella typhimurium Glyoxalase II: New Insights into Metal Ion Selectivity Biochemistry, 46, 2007
|
|
2NXA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2nxa by Molmil](/molmil-images/mine/2nxa) | |
2NZF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2nzf by Molmil](/molmil-images/mine/2nzf) | |
2K6Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2k6z by Molmil](/molmil-images/mine/2k6z) | Solution structures of copper loaded form PCuA (trans conformation of the peptide bond involving the nitrogen of P14) | Descriptor: | COPPER (I) ION, Putative uncharacterized protein TTHA1943 | Authors: | Abriata, L.A, Banci, L, Bertini, I, Ciofi-Baffoni, S, Gkazonis, P.A, Spyroulias, G.A, Vila, A.J, Wang, S. | Deposit date: | 2008-07-28 | Release date: | 2008-09-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Mechanism of Cu(A) assembly. Nat.Chem.Biol., 4, 2008
|
|
2K70
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2k70 by Molmil](/molmil-images/mine/2k70) | Solution structures of copper loaded form PCuA (cis conformation of the peptide bond involving the nitrogen of P14) | Descriptor: | COPPER (I) ION, Putative uncharacterized protein TTHA1943 | Authors: | Abriata, L.A, Banci, L, Bertini, I, Ciofi-Baffoni, S, Gkazonis, P.A, Spyroulias, G.A, Vila, A.J, Wang, S. | Deposit date: | 2008-07-29 | Release date: | 2008-09-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Mechanism of Cu(A) assembly. Nat.Chem.Biol., 4, 2008
|
|
2K6W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2k6w by Molmil](/molmil-images/mine/2k6w) | Solution structures of apo PCuA (trans conformation of the peptide bond involving the nitrogen of P14) | Descriptor: | Putative uncharacterized protein TTHA1943 | Authors: | Abriata, L.A, Banci, L, Bertini, I, Ciofi-Baffoni, S, Gkazonis, P, Spyroulias, G.A, Vila, A.J, Wang, S. | Deposit date: | 2008-07-28 | Release date: | 2008-09-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Mechanism of Cu(A) assembly. Nat.Chem.Biol., 4, 2008
|
|
2K6V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2k6v by Molmil](/molmil-images/mine/2k6v) | Solution structures of apo Sco1 protein from Thermus Thermophilus | Descriptor: | Putative cytochrome c oxidase assembly protein | Authors: | Abriata, L.A, Banci, L, Bertini, I, Ciofi-Baffoni, S, Gkazonis, P, Spyroulias, G.A, Vila, A.J, Wang, S. | Deposit date: | 2008-07-28 | Release date: | 2008-09-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Mechanism of Cu(A) assembly. Nat.Chem.Biol., 4, 2008
|
|
2K6Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2k6y by Molmil](/molmil-images/mine/2k6y) | Solution structures of apo form PCuA (cis conformation of the peptide bond involving the nitrogen of P14) | Descriptor: | Putative uncharacterized protein TTHA1943 | Authors: | Abriata, L.A, Banci, L, Bertini, I, Ciofi-Baffoni, S, Gkazonis, P, Spyroulias, G.A, Vila, A.J, Wang, S. | Deposit date: | 2008-07-28 | Release date: | 2008-09-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Mechanism of Cu(A) assembly. Nat.Chem.Biol., 4, 2008
|
|
2LLN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2lln by Molmil](/molmil-images/mine/2lln) | |