4AN3
 
 | | Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, MAGNESIUM ION, ... | | Authors: | Rice, K.D, Aay, N, Anand, N.K, Blazey, C.M, Bowles, O.J, Bussenius, J, Costanzo, S, Curtis, J.K, Defina, S.C, Dubenko, L, Engst, S, Joshi, A.A, Kennedy, A.R, Kim, A.I, Koltun, E.S, Lougheed, J.C, Manalo, J.C.L, Martini, J.F, Nuss, J.M, Peto, C.J, Tsang, T.H, Yu, P, Johnston, S. | | Deposit date: | 2012-03-15 | | Release date: | 2012-12-19 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Novel Carboxamide-Based Allosteric Mek Inhibitors: Discovery and Optimization Efforts Toward Xl518 (Gdc-0973)
Acs Med.Chem.Lett., 3, 2012
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4AN2
 | | Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. | | Descriptor: | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | Authors: | Rice, K.D, Aay, N, Anand, N.K, Blazey, C.M, Bowles, O.J, Bussenius, J, Costanzo, S, Curtis, J.K, Defina, S.C, Dubenko, L, Engst, S, Joshi, A.A, Kennedy, A.R, Kim, A.I, Koltun, E.S, Lougheed, J.C, Manalo, J.C.L, Martini, J.F, Nuss, J.M, Peto, C.J, Tsang, T.H, Yu, P, Johnston, S. | | Deposit date: | 2012-03-14 | | Release date: | 2012-12-19 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Novel Carboxamide-Based Allosteric Mek Inhibitors: Discovery and Optimization Efforts Toward Xl518 (Gdc-0973)
Acs Med.Chem.Lett., 3, 2012
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4ANB
 | | Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. | | Descriptor: | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | Authors: | Rice, K.D, Aay, N, Anand, N.K, Blazey, C.M, Bowles, O.J, Bussenius, J, Costanzo, S, Curtis, J.K, Defina, S.C, Dubenko, L, Engst, S, Joshi, A.A, Kennedy, A.R, Kim, A.I, Koltun, E.S, Lougheed, J.C, Manalo, J.C.L, Martini, J.F, Nuss, J.M, Peto, C.J, Tsang, T.H, Yu, P, Johnston, S. | | Deposit date: | 2012-03-16 | | Release date: | 2012-12-19 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Novel Carboxamide-Based Allosteric Mek Inhibitors: Discovery and Optimization Efforts Toward Xl518 (Gdc-0973)
Acs Med.Chem.Lett., 3, 2012
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4AN9
 | | Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. | | Descriptor: | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | Authors: | Rice, K.D, Aay, N, Anand, N.K, Blazey, C.M, Bowles, O.J, Bussenius, J, Costanzo, S, Curtis, J.K, Defina, S.C, Dubenko, L, Engst, S, Joshi, A.A, Kennedy, A.R, Kim, A.I, Koltun, E.S, Lougheed, J.C, Manalo, J.C.L, Martini, J.F, Nuss, J.M, Peto, C.J, Tsang, T.H, Yu, P, Johnston, S. | | Deposit date: | 2012-03-16 | | Release date: | 2012-12-19 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Novel Carboxamide-Based Allosteric Mek Inhibitors: Discovery and Optimization Efforts Toward Xl518 (Gdc-0973)
Acs Med.Chem.Lett., 3, 2012
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6AID
 | | Structural insights into the unique polylactate degrading mechanism of Thermobifida alba cutinase | | Descriptor: | CALCIUM ION, Esterase, LACTIC ACID, ... | | Authors: | Kitadokoro, K, Kakara, M, Matsui, S, Osokoshi, R, Thumarat, U, Kawai, F, Kamitani, S. | | Deposit date: | 2018-08-22 | | Release date: | 2019-02-27 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structural insights into the unique polylactate-degrading mechanism of Thermobifida alba cutinase.
Febs J., 286, 2019
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2YT5
 | | Solution structure of the PHD domain of Metal-response element-binding transcription factor 2 | | Descriptor: | Metal-response element-binding transcription factor 2, ZINC ION | | Authors: | Masuda, K, Muto, Y, Isono, K, Watanabe, S, Harada, T, Kigawa, T, Koseki, H, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-04-05 | | Release date: | 2008-04-15 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the PHD domain of Metal-response element-binding transcription factor 2
To be Published
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3AFG
 | | Crystal structure of ProN-Tk-SP from Thermococcus kodakaraensis | | Descriptor: | CALCIUM ION, Subtilisin-like serine protease | | Authors: | Foophow, T, Tanaka, S, Angkawidjaja, C, Koga, Y, Takano, K, Kanaya, S. | | Deposit date: | 2010-03-01 | | Release date: | 2010-08-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of a subtilisin homologue, Tk-SP, from Thermococcus kodakaraensis: requirement of a C-terminal beta-jelly roll domain for hyperstability.
J.Mol.Biol., 400, 2010
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1U9I
 | | Crystal Structure of Circadian Clock Protein KaiC with Phosphorylation Sites | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, KaiC, MAGNESIUM ION | | Authors: | Xu, Y, Mori, T, Pattanayek, R, Pattanayek, S, Egli, M, Johnson, C.H. | | Deposit date: | 2004-08-09 | | Release date: | 2005-04-19 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Identification of key phosphorylation sites in the circadian clock protein KaiC by crystallographic and mutagenetic analyses
PROC.NATL.ACAD.SCI.USA, 101, 2004
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2E9G
 | | Solution structure of the alpha adaptinC2 domain from human Adapter-related protein complex 1 gamma 2 subunit | | Descriptor: | AP-1 complex subunit gamma-2 | | Authors: | Tomizawa, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-01-25 | | Release date: | 2007-07-31 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the alpha adaptinC2 domain from human Adapter-related protein complex 1 gamma 2 subunit
To be Published
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2ECN
 | | Solution structure of the RING domain of the human RING finger protein 141 | | Descriptor: | RING finger protein 141, ZINC ION | | Authors: | Miyamoto, K, Tochio, N, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-02-13 | | Release date: | 2007-08-14 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the RING domain of the human RING finger protein 141
To be Published
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2EE3
 | | Solution structures of the fn3 domain of human collagen alpha-1(XX) chain | | Descriptor: | Collagen alpha-1(XX) chain | | Authors: | Sato, M, Tochio, N, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-02-15 | | Release date: | 2007-08-21 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structures of the fn3 domain of human collagen alpha-1(XX) chain
To be Published
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3AM2
 | | Clostridium perfringens enterotoxin | | Descriptor: | GLYCEROL, Heat-labile enterotoxin B chain, UNKNOWN ATOM OR ION | | Authors: | Kitadokoro, K, Nishimura, K, Kamitani, S, Kimura, J, Fukui, A, Abe, H, Horiguchi, Y. | | Deposit date: | 2010-08-12 | | Release date: | 2011-04-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Crystal Structure of Clostridium perfringens Enterotoxin Displays Features of {beta}-Pore-forming Toxins
J.Biol.Chem., 286, 2011
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2DZI
 | | 2DZI/Solution Structure of the N-terminal Ubiquitin-like Domain in Human Ubiquitin-like Protein 4A (GDX) | | Descriptor: | Ubiquitin-like protein 4A | | Authors: | Zhao, C, Sato, M, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-09-29 | | Release date: | 2007-03-29 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | 2DZI/Solution Structure of the N-terminal Ubiquitin-like Domain in Human Ubiquitin-like Protein 4A (GDX)
To be Published
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2EKX
 | | Solution structure of the human BMX SH2 domain | | Descriptor: | Cytoplasmic tyrosine-protein kinase BMX | | Authors: | Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-26 | | Release date: | 2007-10-02 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the human BMX SH2 domain
To be Published
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2ECJ
 | | Solution structure of the RING domain of the human tripartite motif-containing protein 39 | | Descriptor: | Tripartite motif-containing protein 39, ZINC ION | | Authors: | Miyamoto, K, Sato, M, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-02-13 | | Release date: | 2007-08-14 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the RING domain of the human tripartite motif-containing protein 39
To be Published
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2EE1
 | | Solution structures of the Chromo domain of human chromodomain helicase-DNA-binding protein 4 | | Descriptor: | Chromodomain helicase-DNA-binding protein 4 | | Authors: | Sato, M, Tochio, N, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-02-15 | | Release date: | 2007-08-21 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structures of the Chromo domain of human chromodomain helicase-DNA-binding protein 4
To be Published
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2E8O
 | | Solution structure of the N-terminal SAM-domain of the SAM domain and HD domain containing protein 1 (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) | | Descriptor: | SAM domain and HD domain-containing protein 1 | | Authors: | Goroncy, A.K, Tochio, N, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-01-22 | | Release date: | 2007-07-24 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the N-terminal SAM-domain of the SAM domain and HD domain containing protein 1 (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5)
To be Published
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2DZK
 | | Structure of the UBX domain in Mouse UBX Domain-Containing Protein 2 | | Descriptor: | UBX domain-containing protein 2 | | Authors: | Zhao, C, Yoneyama, M, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-09-29 | | Release date: | 2007-03-29 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structure of the UBX domain in Mouse UBX Domain-Containing Protein 2
To be Published
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2E6I
 | | Solution structure of the BTK motif of tyrosine-protein kinase ITK from human | | Descriptor: | Tyrosine-protein kinase ITK/TSK, ZINC ION | | Authors: | Li, H, Tochio, N, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-12-27 | | Release date: | 2007-07-03 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the BTK motif of tyrosine-protein kinase ITK from human
To be Published
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2E9K
 | | Solution structure of the CH domain from human MICAL-2 | | Descriptor: | Protein MICAL-2 | | Authors: | Tomizawa, T, Tochio, N, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-01-25 | | Release date: | 2007-07-31 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the CH domain from human MICAL-2
To be Published
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2ECL
 | | Solution Structure of the RING domain of the human RING-box protein 2 | | Descriptor: | RING-box protein 2, ZINC ION | | Authors: | Miyamoto, K, Tomizawa, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-02-13 | | Release date: | 2007-08-14 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of the RING domain of the human RING-box protein 2
To be Published
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2EEE
 | | Solution structure of the A1pp domain from human protein C6orf130 | | Descriptor: | Uncharacterized protein C6orf130 | | Authors: | Tomizawa, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-02-15 | | Release date: | 2007-08-21 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the A1pp domain from human protein C6orf130
To be Published
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2ECM
 | | Solution structure of the RING domain of the RING finger and CHY zinc finger domain-containing protein 1 from Mus musculus | | Descriptor: | RING finger and CHY zinc finger domain-containing protein 1, ZINC ION | | Authors: | Miyamoto, K, Yoneyama, M, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-02-13 | | Release date: | 2007-08-14 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the RING domain of the RING finger and CHY zinc finger domain-containing protein 1 from Mus musculus
To be Published
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2EEA
 | | Solution structure of the 17th filamin domain from human Filamin-B | | Descriptor: | Filamin-B | | Authors: | Tomizawa, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-02-15 | | Release date: | 2007-08-21 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the 17th filamin domain from human Filamin-B
To be Published
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2EL8
 | | Solution structure of the human STAP2 SH2 domain | | Descriptor: | Signal-transducing adaptor protein 2 | | Authors: | Kasai, T, Miyamoto, K, Tochio, N, Tomizawa, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-26 | | Release date: | 2007-10-02 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the human STAP2 SH2 domain
To be Published
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