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PDB: 184 件
6JT3
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Crystal Structure of BACE1 in complex with N-{3-[(4R,5R,6R)-2-amino-5-fluoro-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide
分子名称: Beta-secretase 1, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Tadano, G, Komano, K, Yoshida, S, Suzuki, S, Nakahara, K, Fuchino, K, Fujimoto, K, Matsuoka, E, Yamamoto, T, Asada, N, Ito, H, Sakaguchi, G, Kanegawa, N, Kido, Y, Ando, S, Fukushima, T, Teisman, A, Urmaliya, V, Dhuyvetter, D, Borghys, H, Bergh, A.V.D, Austin, N, Gijsen, H.J.M, Yamano, Y, Iso, Y, Kusakabe, K.I.
登録日2019-04-08
公開日2019-10-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of an Extremely Potent Thiazine-Based beta-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose.
J.Med.Chem., 62, 2019
6JT4
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Crystal Structure of BACE1 in complex with N-{3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide
分子名称: Beta-secretase 1, GLYCEROL, IODIDE ION, ...
著者Anan, K, Iso, Y, Oguma, T, Nakahara, K, Suzuki, S, Yamamoto, T, Matsuoka, E, Ito, H, Sakaguchi, G, Ando, S, Morimoto, K, Kanegawa, N, Kido, Y, Kawachi, T, Fukushima, T, Teisman, A, Urmaliya, V, Dhuyvetter, D, Borghys, H, Austin, N, Bergh, A.V.D, Verboven, P, Bischoff, F, Gijsen, H.J.M, Yamano, Y, Kusakabe, K.I.
登録日2019-04-08
公開日2020-01-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Trifluoromethyl Dihydrothiazine-Based beta-Secretase (BACE1) Inhibitors with Robust Central beta-Amyloid Reduction and Minimal Covalent Binding Burden.
Chemmedchem, 14, 2019
1WS8
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BU of 1ws8 by Molmil
Crystal Structure of Mavicyanin from Cucurbita pepo medullosa (Zucchini)
分子名称: COPPER (II) ION, GLYCEROL, mavicyanin
著者Xie, Y, Inoue, T, Miyamoto, Y, Matsumura, H, Kunishige, K, Yamaguchi, K, Nojini, M, Suzuki, S, Kai, Y.
登録日2004-11-02
公開日2004-11-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural reorganization of the copper binding site involving Thr15 of mavicyanin from Cucurbita pepo medullosa (zucchini) upon reduction.
J.Biochem.(Tokyo), 137, 2005
1WS7
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Crystal Structure of Mavicyanin from Cucurbita pepo medullosa (Zucchini)
分子名称: COPPER (I) ION, Mavicyanin
著者Xie, Y, Inoue, T, Miyamoto, Y, Matsumura, H, Kataoka, K, Yamaguchi, K, Nojini, M, Suzuki, S, Kai, Y.
登録日2004-11-02
公開日2004-11-23
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural reorganization of the copper binding site involving Thr15 of mavicyanin from Cucurbita pepo medullosa (zucchini) upon reduction.
J.Biochem.(Tokyo), 137, 2005
2DO3
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BU of 2do3 by Molmil
Solution structure of the third KOW motif of transcription elongation factor SPT5
分子名称: Transcription elongation factor SPT5
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2006-04-27
公開日2006-10-27
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the third KOW motif of transcription elongation factor SPT5
To be Published
2EPP
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BU of 2epp by Molmil
Solution structure of the first C2H2 type zinc finger domain of Zinc finger protein 278
分子名称: POZ-, AT hook-, and zinc finger-containing protein 1, ...
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2008-02-12
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the first C2H2 type zinc finger domain of Zinc finger protein 278
To be Published
2EQY
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Solution structure of the ARID domain of Jarid1b protein
分子名称: Jumonji, AT rich interactive domain 1B
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the ARID domain of Jarid1b protein
To be Published
2E70
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Solution structure of the fifth KOW motif of human transcription elongation factor SPT5
分子名称: Transcription elongation factor SPT5
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-01-05
公開日2007-07-10
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the fifth KOW motif of human transcription elongation factor SPT5
To be Published
2E71
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Solution structure of the second FF domain of human transcription factor CA150
分子名称: Transcription elongation regulator 1
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-01-05
公開日2007-07-10
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the second FF domain of human transcription factor CA150
To be Published
2EQX
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BU of 2eqx by Molmil
Solution structure of the BACK domain of Kelch repeat and BTB domain-containing protein 4
分子名称: Kelch repeat and BTB domain-containing protein 4
著者Imai, M, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the BACK domain of Kelch repeat and BTB domain-containing protein 4
To be Published
2E6Z
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BU of 2e6z by Molmil
Solution structure of the second KOW motif of human transcription elongation factor SPT5
分子名称: Transcription elongation factor SPT5
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-01-05
公開日2007-07-10
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the second KOW motif of human transcription elongation factor SPT5
To be Published
2EPW
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BU of 2epw by Molmil
Solution structure of the 24th C2H2 type zinc finger domain of Zinc finger protein 268
分子名称: ZINC ION, Zinc finger protein 268
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the 24th C2H2 type zinc finger domain of Zinc finger protein 268
To be Published
2EPQ
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Solution structure of the third zinc finger domain of Zinc finger protein 278
分子名称: POZ-, AT hook-, and zinc finger-containing protein 1, ...
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2008-02-12
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the third zinc finger domain of Zinc finger protein 278
To be Published
2EQ4
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BU of 2eq4 by Molmil
Solution structure of the 11th C2H2 type zinc finger domain of Zinc finger protein 224
分子名称: ZINC ION, Zinc finger protein 224
著者Masuda, K, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the 11th C2H2 type zinc finger domain of Zinc finger protein 224
To be Published
2EPY
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BU of 2epy by Molmil
Solution structure of the 10th C2H2 type zinc finger domain of Zinc finger protein 268
分子名称: ZINC ION, Zinc finger protein 268
著者Imai, M, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the 10th C2H2 type zinc finger domain of Zinc finger protein 268
To be Published
2EQW
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Solution structure of the 6th C2H2 type zinc finger domain of Zinc finger protein 484
分子名称: ZINC ION, Zinc finger protein 484
著者Imai, M, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the 6th C2H2 type zinc finger domain of Zinc finger protein 484
To be Published
2EPS
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Solution structure of the 4th zinc finger domain of Zinc finger protein 278
分子名称: POZ-, AT hook-, and zinc finger-containing protein 1, ...
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the 4th zinc finger domain of Zinc finger protein 278
To be Published
2EQU
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Solution structure of the tudor domain of PHD finger protein 20-like 1
分子名称: PHD finger protein 20-like 1
著者Futami, K, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the tudor domain of PHD finger protein 20-like 1
To be Published
2EPZ
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BU of 2epz by Molmil
Solution structure of the 4th C2H2 type zinc finger domain of Zinc finger protein 28 homolog
分子名称: ZINC ION, Zinc finger protein 28 homolog
著者Futami, K, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the 4th C2H2 type zinc finger domain of Zinc finger protein 28 homolog
To be Published
2EPV
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BU of 2epv by Molmil
Solution structure of the 20th C2H2 type zinc finger domain of Zinc finger protein 268
分子名称: ZINC ION, Zinc finger protein 268
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the 20th C2H2 type zinc finger domain of Zinc finger protein 268
To be Published
2EQ1
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Solution structure of the 9th C2H2 type zinc finger domain of Zinc finger protein 347
分子名称: ZINC ION, Zinc finger protein 347
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the 9th C2H2 type zinc finger domain of Zinc finger protein 347
To be Published
2EPU
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Solution structure of the secound C2H2 type zinc finger domain of Zinc finger protein 32
分子名称: ZINC ION, Zinc finger protein 32
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the secound C2H2 type zinc finger domain of Zinc finger protein 32
To be Published
2EQ2
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Solution structure of the 16th C2H2 type zinc finger domain of Zinc finger protein 347
分子名称: ZINC ION, Zinc finger protein 347
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the 16th C2H2 type zinc finger domain of Zinc finger protein 347
To be Published
2EQ0
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Solution structure of the 8th C2H2 type zinc finger domain of Zinc finger protein 347
分子名称: ZINC ION, Zinc finger protein 347
著者Masuda, K, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the 8th C2H2 type zinc finger domain of Zinc finger protein 347
To be Published
2EPX
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Solution structure of the third C2H2 type zinc finger domain of Zinc finger protein 28 homolog
分子名称: ZINC ION, Zinc finger protein 28 homolog
著者Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-30
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the third C2H2 type zinc finger domain of Zinc finger protein 28 homolog
To be Published

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件を2024-07-24に公開中

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