5KJY
| Co-crystal structure of PKA RI alpha CNB-B mutant (G316R/A336T) with cAMP | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase type I-alpha regulatory subunit | 著者 | Lorenz, R, Moon, E, Kim, J.J, Huang, G.Y, Kim, C, Herberg, F.W. | 登録日 | 2016-06-20 | 公開日 | 2017-06-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity. Biochem. J., 474, 2017
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8U4L
| Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | 著者 | Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N. | 登録日 | 2023-09-10 | 公開日 | 2024-03-13 | 最終更新日 | 2024-09-25 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation. Elife, 12, 2024
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8U4K
| Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Betacellulin, ... | 著者 | Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N. | 登録日 | 2023-09-10 | 公開日 | 2024-03-13 | 最終更新日 | 2024-09-25 | 実験手法 | ELECTRON MICROSCOPY (4.27 Å) | 主引用文献 | Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation. Elife, 12, 2024
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6M8H
| Crystal Structure of the R208Q mutant of G(i) subunit alpha-1 | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION | 著者 | Mascarenhas, R, Goossens, J, Leverson, B, Kothawala, S, Ballicora, M, Olsen, K, de freitas, D, Liu, D. | 登録日 | 2018-08-21 | 公開日 | 2019-08-21 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | FUNCTIONAL CONSEQUENCES OF ONCOGENIC MUTATIONS IN THE SWITCH II REGION OF Galphai1 and Galphas PROTEINS To Be Published
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7AB5
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7AB3
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7AB4
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5KJZ
| Co-crystal structure of PKA RI alpha CNB-B mutant (G316R/A336T) with cGMP | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL, cAMP-dependent protein kinase type I-alpha regulatory subunit | 著者 | Lorenz, R, Moon, E, Kim, J.J, Huang, G.Y, Kim, C, Herberg, F.W. | 登録日 | 2016-06-20 | 公開日 | 2017-06-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.347 Å) | 主引用文献 | Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity. Biochem. J., 474, 2017
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8FMI
| Crystal structure of human KRAS at 1.12 A | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION | 著者 | Brenner, R, Landgraf, A, Gonzalez-Gutierrez, G, Bum-Erdene, K, Meroueh, S.O. | 登録日 | 2022-12-23 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling. Biochemistry, 62, 2023
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8FMK
| Crystal structure of human KRAS with extended switch I loop | 分子名称: | CHLORIDE ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Brenner, R, Landgraf, A, Gonzalez-Gutierrez, G, Bum-Erdene, K, Meroueh, S.O. | 登録日 | 2022-12-23 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling. Biochemistry, 62, 2023
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6B6G
| Crystal Structure of GABA Aminotransferase bound to (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, an Potent Inactivatorfor the Treatment of Addiction | 分子名称: | (3R,4E)-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]cyclopent-1-ene-1,3-dicarboxylic acid, 4-aminobutyrate aminotransferase, mitochondrial, ... | 著者 | Mascarenhas, R, Juncosa, J.I, Takaya, K, Le, L.V, Moschitto, M.J, Silverman, R.B, Liu, D. | 登録日 | 2017-10-02 | 公開日 | 2018-02-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent gamma-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. J. Am. Chem. Soc., 140, 2018
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8T9O
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7L5F
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4ZDP
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4ZDO
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3QSU
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8QAI
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8QAH
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8QKD
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8QAG
| X-ray crystal structure of a de novo designed single-chain parallel coiled-coil alpha-helical barrel with 6 inner helices, sc-CC-6-95 | 分子名称: | DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL, sc-CC-6-95 | 著者 | Petrenas, R, Albanese, K.I, Woolfson, D.N. | 登録日 | 2023-08-22 | 公開日 | 2024-07-03 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Rationally seeded computational protein design of ɑ-helical barrels. Nat.Chem.Biol., 20, 2024
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8T9P
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4WYP
| The crystal structure of the A109G mutant of RNase A in complex with 5'AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, Ribonuclease pancreatic | 著者 | French, R.L, Gagne, D, Doucet, N, Simonovic, M. | 登録日 | 2014-11-17 | 公開日 | 2015-11-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.502 Å) | 主引用文献 | Perturbation of the Conformational Dynamics of an Active-Site Loop Alters Enzyme Activity. Structure, 23, 2015
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4WYN
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4WYZ
| The crystal structure of the A109G mutant of RNase A in complex with 3'UMP | 分子名称: | 3'-URIDINEMONOPHOSPHATE, Ribonuclease pancreatic | 著者 | French, R.L, Gagne, D, Doucet, N, Simonovic, M. | 登録日 | 2014-11-18 | 公開日 | 2015-11-18 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (1.449 Å) | 主引用文献 | Perturbation of the Conformational Dynamics of an Active-Site Loop Alters Enzyme Activity. Structure, 23, 2015
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4ZO2
| AidC, a Dizinc Quorum-Quenching Lactonase | 分子名称: | Acylhomoserine lactonase, ZINC ION | 著者 | Mascarenhas, R, Thomas, P.W, Wu, C.-X, Nocek, B.P, Hoang, Q, Fast, W, Liu, D. | 登録日 | 2015-05-05 | 公開日 | 2015-07-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | 主引用文献 | Structural and Biochemical Characterization of AidC, a Quorum-Quenching Lactonase with Atypical Selectivity. Biochemistry, 54, 2015
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