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PDB: 2 results

1T84
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BU of 1t84 by Molmil
Solution structure of the Wiskott-Aldrich Syndrome Protein (WASP) autoinhibited core domain complexed with (S)-wiskostatin, a small molecule inhibitor
Descriptor: (2S)-1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL, Wiskott-Aldrich syndrome protein
Authors:Peterson, J.R, Bickford, L.C, Morgan, D, Kim, A.S, Ouerfelli, O, Kirschner, M.W, Rosen, M.K.
Deposit date:2004-05-11
Release date:2004-07-13
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.
Nat.Struct.Mol.Biol., 11, 2004
4IBM
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BU of 4ibm by Molmil
Crystal structure of insulin receptor kinase domain in complex with an inhibitor Irfin-1
Descriptor: 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3H-pyrazolo[3,4-c]pyridazin-3-one, Insulin receptor
Authors:Wu, J, Anastassiadis, T, Duong-Ly, K.C, Peterson, J.R.
Deposit date:2012-12-08
Release date:2013-08-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor.
J.Biol.Chem., 288, 2013

226707

数据于2024-10-30公开中

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