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PDB: 59 件

6NRH
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BU of 6nrh by Molmil
Crystal Structure of human PARP-1 ART domain bound inhibitor UTT63
分子名称: 3-hydroxy-2-({4-[4-(pyrimidin-2-yl)piperazine-1-carbonyl]phenyl}methyl)-1-benzofuran-7-carboxamide, DIMETHYL SULFOXIDE, Poly [ADP-ribose] polymerase 1, ...
著者Langelier, M.F, Pascal, J.M.
登録日2019-01-23
公開日2019-08-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.
J.Med.Chem., 62, 2019
1OBT
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BU of 1obt by Molmil
STRUCTURE OF RICIN A CHAIN MUTANT, COMPLEX WITH AMP
分子名称: ADENOSINE MONOPHOSPHATE, RICIN A CHAIN
著者Day, P.J, Ernst, S.R, Frankel, A.E, Monzingo, A.F, Pascal, J.M, Svinth, M, Robertus, J.D.
登録日1996-06-22
公開日1997-06-16
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure and activity of an active site substitution of ricin A chain.
Biochemistry, 35, 1996
1OBS
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BU of 1obs by Molmil
STRUCTURE OF RICIN A CHAIN MUTANT
分子名称: RICIN A CHAIN
著者Day, P.J, Ernst, S.R, Frankel, A.E, Monzingo, A.F, Pascal, J.M, Svinth, M, Robertus, J.D.
登録日1996-06-25
公開日1997-06-16
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure and activity of an active site substitution of ricin A chain.
Biochemistry, 35, 1996
6VKQ
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BU of 6vkq by Molmil
Crystal Structure of human PARP-1 CAT domain bound to inhibitor EB-47
分子名称: 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Poly [ADP-ribose] polymerase 1, SULFATE ION
著者Steffen, J.D, Pascal, J.M.
登録日2020-01-21
公開日2020-06-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for allosteric PARP-1 retention on DNA breaks.
Science, 368, 2020
6VKK
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BU of 6vkk by Molmil
Crystal Structure of human PARP-1 CAT domain bound to inhibitor rucaparib
分子名称: GLYCEROL, Poly [ADP-ribose] polymerase 1, Rucaparib, ...
著者Steffen, J.D, Pascal, J.M.
登録日2020-01-21
公開日2020-06-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for allosteric PARP-1 retention on DNA breaks.
Science, 368, 2020
6VKO
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BU of 6vko by Molmil
Crystal Structure of human PARP-1 CAT domain bound to inhibitor UKTT15
分子名称: Poly [ADP-ribose] polymerase 1, SULFATE ION, methyl 2-{4-[4-(7-carbamoyl-1H-benzimidazol-2-yl)benzene-1-carbonyl]piperazin-1-yl}pyrimidine-5-carboxylate
著者Langelier, M.F, Pascal, J.M.
登録日2020-01-21
公開日2020-06-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for allosteric PARP-1 retention on DNA breaks.
Science, 368, 2020
7RPX
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BU of 7rpx by Molmil
Archaeal DNA ligase and heterotrimeric PCNA in complex with end-joined DNA
分子名称: DNA ligase, DNA polymerase sliding clamp 1, DNA polymerase sliding clamp 2, ...
著者Sverzhinsky, A, Pascal, J.M.
登録日2021-08-04
公開日2021-11-17
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase.
Structure, 30, 2022
7RPO
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BU of 7rpo by Molmil
Archaeal DNA ligase and heterotrimeric PCNA in complex with non-ligatable DNA
分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase, DNA polymerase sliding clamp 1, ...
著者Sverzhinsky, A, Pascal, J.M.
登録日2021-08-03
公開日2021-11-17
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (4.16 Å)
主引用文献Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase.
Structure, 30, 2022
7RPW
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BU of 7rpw by Molmil
Archaeal DNA ligase and heterotrimeric PCNA in complex with adenylated DNA
分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase, DNA polymerase sliding clamp 1, ...
著者Sverzhinsky, A, Pascal, J.M.
登録日2021-08-04
公開日2021-11-17
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.38 Å)
主引用文献Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase.
Structure, 30, 2022
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