6B63
| IMPase (AF2372) with 25 mM Asp | 分子名称: | (2R)-2,3-dihydroxypropyl (2S)-2,3-dihydroxypropyl hydrogen phosphate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Fructose-1,6-bisphosphatase/inositol-1-monophosphatase, ... | 著者 | Goldstein, R.I, Roberts, M. | 登録日 | 2017-10-01 | 公開日 | 2018-10-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.696 Å) | 主引用文献 | Osmolyte binding capacity of a dual action IMPase/FBPase (AF2372) To Be Published
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6B64
| IMPase (AF2372) with 25 mM Asp | 分子名称: | ASPARTIC ACID, Fructose-1,6-bisphosphatase/inositol-1-monophosphatase, MAGNESIUM ION, ... | 著者 | Goldstein, R.I, Roberts, M. | 登録日 | 2017-10-01 | 公開日 | 2018-10-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Osmolyte binding capacity of a dual action IMPase/FBPase (AF2372) To Be Published
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6B66
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1G0H
| CRYSTAL STRUCTURE OF MJ0109 GENE PRODUCT INOSITOL MONOPHOSPHATASE-FRUCTOSE 1,6 BISPHOSPHATASE | 分子名称: | CALCIUM ION, D-MYO-INOSITOL-1-PHOSPHATE, INOSITOL MONOPHOSPHATASE | 著者 | Johnson, K.A, Chen, L, Yang, H, Roberts, M.F, Stec, B. | 登録日 | 2000-10-06 | 公開日 | 2001-03-14 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure and catalytic mechanism of the MJ0109 gene product: a bifunctional enzyme with inositol monophosphatase and fructose 1,6-bisphosphatase activities. Biochemistry, 40, 2001
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6B2C
| Macrophage Migration Inhibitory Factor in Complex with a Naphthyridinone Inhibitor (4b) | 分子名称: | Macrophage migration inhibitory factor, SULFATE ION, {2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-8-oxo-1,7-naphthyridin-7(8H)-yl}acetic acid | 著者 | Krimmer, S.G, Robertson, M.J, Jorgensen, W.L. | 登録日 | 2017-09-19 | 公開日 | 2018-01-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett, 8, 2017
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6B65
| IMPase (AF2372) R92Q/K164E | 分子名称: | DI(HYDROXYETHYL)ETHER, Fructose-1,6-bisphosphatase/inositol-1-monophosphatase, ISOPROPYL ALCOHOL, ... | 著者 | Goldstein, R.I, Roberts, M. | 登録日 | 2017-10-01 | 公開日 | 2018-10-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.702 Å) | 主引用文献 | Osmolyte binding capacity of a dual action IMPase/FBPase (AF2372) To Be Published
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6B1C
| Macrophage Migration Inhibitory Factor in complex with a Naphthyridinone Inhibitor (4a) | 分子名称: | 2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-7-methyl-1,7-naphthyridin-8(7H)-one, Macrophage migration inhibitory factor, SULFATE ION | 著者 | Krimmer, S.G, Robertson, M.J, Jorgensen, W.L. | 登録日 | 2017-09-18 | 公開日 | 2018-01-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.163 Å) | 主引用文献 | Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett, 8, 2017
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4RV3
| Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ACETATE ION | 著者 | He, T, Gershenson, A, Eyles, S.J, Gao, J, Roberts, M.F. | 登録日 | 2014-11-24 | 公開日 | 2015-07-01 | 最終更新日 | 2018-08-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fluorinated Aromatic Amino Acids Distinguish Cation-pi Interactions from Membrane Insertion. J.Biol.Chem., 290, 2015
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2XUZ
| Crystal structure of the triscatecholate siderophore binding protein FeuA from Bacillus subtilis complexed with Ferri-Enterobactin | 分子名称: | DI(HYDROXYETHYL)ETHER, FE (III) ION, IRON-UPTAKE SYSTEM-BINDING PROTEIN, ... | 著者 | Peuckert, F, Miethke, M, Schwoerer, C.J, Albrecht, A.G, Oberthuer, M, Marahiel, M.A. | 登録日 | 2010-10-22 | 公開日 | 2011-08-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Siderophore Binding Protein Feua Shows Limited Promiscuity Toward Exogenous Triscatecholates Chem.Biol., 18, 2011
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2XV1
| Crystal structure of the triscatecholate siderophore binding protein FeuA from Bacillus subtilis complexed with Ferric MECAM | 分子名称: | DI(HYDROXYETHYL)ETHER, FE (III) ION, IRON-UPTAKE SYSTEM-BINDING PROTEIN, ... | 著者 | Peuckert, F, Miethke, M, Schwoerer, C.J, Albrecht, A.G, Oberthuer, M, Marahiel, M.A. | 登録日 | 2010-10-22 | 公開日 | 2011-08-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | The Siderophore Binding Protein Feua Shows Limited Promiscuity Toward Exogenous Triscatecholates Chem.Biol., 18, 2011
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4AXH
| Structure and mechanism of the first inverting alkylsulfatase specific for secondary alkylsulfatases | 分子名称: | SEC-ALKYLSULFATASE, SULFATE ION, ZINC ION | 著者 | Knaus, T, Schober, M, Faber, K, Macheroux, P, Wagner, U.G. | 登録日 | 2012-06-13 | 公開日 | 2012-12-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure and Mechanism of an Inverting Alkylsulfatase from Pseudomonas Sp. Dsm6611 Specific for Secondary Alkylsulfates. FEBS J., 279, 2012
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3QW2
| L-myo-inositol 1-phosphate synthase from Archaeoglobus mutant N255A | 分子名称: | GLYCEROL, Myo-inositol-1-phosphate synthase (Ino1), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Neelon, K, Roberts, M.F, Stec, B. | 登録日 | 2011-02-26 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Crystal structure of a trapped catalytic intermediate suggests that forced atomic proximity drives the catalysis of mIPS. Biophys.J., 101, 2011
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2YHE
| Structure determination of the stereoselective inverting sec- alkylsulfatase Pisa1 from Pseudomonas sp. | 分子名称: | SEC-ALKYL SULFATASE, SULFATE ION, ZINC ION | 著者 | Kepplinger, B, Faber, K, Macheroux, P, Schober, M, Knaus, T, Wagner, U.G. | 登録日 | 2011-04-29 | 公開日 | 2012-05-16 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure and Mechanism of an Inverting Alkylsulfatase from Pseudomonas Sp. Dsm6611 Specific for Secondary Alkylsulfates. FEBS J., 279, 2012
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3QVS
| L-myo-inositol 1-phosphate synthase from Archaeoglobus fulgidus wild type | 分子名称: | GLYCEROL, Myo-inositol-1-phosphate synthase (Ino1), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Neelon, K, Roberts, M.F, Stec, B. | 登録日 | 2011-02-25 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of a trapped catalytic intermediate suggests that forced atomic proximity drives the catalysis of mIPS. Biophys.J., 101, 2011
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2QFL
| Structure of SuhB: Inositol monophosphatase and extragenic suppressor from E. coli | 分子名称: | ACETATE ION, ETHYL ACETATE, Inositol-1-monophosphatase | 著者 | Wang, Y, Stieglitz, K.A, Bubunenko, M, Court, D, Stec, B, Roberts, M.F. | 登録日 | 2007-06-27 | 公開日 | 2007-07-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The structure of the R184A mutant of the inositol monophosphatase encoded by suhB and implications for its functional interactions in Escherichia coli. J.Biol.Chem., 282, 2007
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2JUY
| NMR ensemble of Neopetrosiamide A | 分子名称: | Neopetrosiamide A | 著者 | Austin, P, Williams, D.E, Heller, M, McIntosh, L.P, Andersen, R.J, Roberge, M, Roskelley, C.D. | 登録日 | 2007-09-05 | 公開日 | 2008-08-26 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR ensemble of Neopetrosiamide A To be Published
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3QVW
| L-myo-inositol 1-phosphate synthase from Archaeoglobus fulgidus mutant K278A | 分子名称: | GLYCEROL, Myo-inositol-1-phosphate synthase (Ino1), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Neelon, K, Roberts, M.F, Stec, B. | 登録日 | 2011-02-26 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of a trapped catalytic intermediate suggests that forced atomic proximity drives the catalysis of mIPS. Biophys.J., 101, 2011
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1U1I
| Myo-inositol phosphate synthase mIPS from A. fulgidus | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PHOSPHATE ION, POTASSIUM ION, ... | 著者 | Stieglitz, K.A, Yang, H, Roberts, M.F, Stec, B. | 登録日 | 2004-07-15 | 公開日 | 2004-08-10 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Reaching for Mechanistic Consensus Across Life Kingdoms: Structure and Insights into Catalysis of the myo-Inositol-1-phosphate Synthase (mIPS) from Archaeoglobus fulgidus Biochemistry, 44, 2005
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1U1U
| A. thaliana cobalamine independent methionine synthase | 分子名称: | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, SULFATE ION, ZINC ION | 著者 | Ferrer, J.-L, Ravanel, S, Robert, M, Dumas, R. | 登録日 | 2004-07-16 | 公開日 | 2004-09-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate J.Biol.Chem., 279, 2004
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1LBY
| Crystal Structure of a complex (P32 crystal form) of dual activity FBPase/IMPase (AF2372) from Archaeoglobus fulgidus with 3 Manganese ions, Fructose-6-Phosphate, and Phosphate ion | 分子名称: | 6-O-phosphono-beta-D-fructofuranose, MANGANESE (II) ION, PHOSPHATE ION, ... | 著者 | Stieglitz, K.A, Johnson, K.A, Yang, H, Roberts, M.F, Seaton, B.A, Head, J.F, Stec, B. | 登録日 | 2002-04-04 | 公開日 | 2002-05-22 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop. J.Biol.Chem., 277, 2002
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4F2T
| Modulation of S.aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding. | 分子名称: | 1-phosphatidylinositol phosphodiesterase, ACETATE ION | 著者 | Cheng, J, Goldstein, R, Stec, B, Gershenson, A, Roberts, M.F. | 登録日 | 2012-05-08 | 公開日 | 2012-12-12 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity. J.Biol.Chem., 287, 2012
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4F2B
| Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase | 著者 | Cheng, J, Goldstein, R, Stec, B, Gershenson, A, Roberts, M.F. | 登録日 | 2012-05-07 | 公開日 | 2012-12-12 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity. J.Biol.Chem., 287, 2012
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3V16
| An intramolecular pi-cation latch in phosphatidylinositol-specific phospholipase C from S.aureus controls substrate access to the active site | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, CHLORIDE ION | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Roberts, M.F. | 登録日 | 2011-12-09 | 公開日 | 2012-04-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure of the S. aureus PI-Specific Phospholipase C Reveals Modulation of Active Site Access by a Titratable PI-Cation Latched Loop Biochemistry, 51, 2012
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3QVT
| L-myo-inositol 1-phosphate synthase from Archaeoglobus fulgidus wild-type with the intermediate 5-keto 1-phospho glucose | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, Myo-inositol-1-phosphate synthase (Ino1), ... | 著者 | Neelon, K, Roberts, M.F, Stec, B. | 登録日 | 2011-02-25 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of a trapped catalytic intermediate suggests that forced atomic proximity drives the catalysis of mIPS. Biophys.J., 101, 2011
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3QVX
| L-myo-inositol 1-phosphate synthase from Archaeoglobus fulgidus mutant K367A | 分子名称: | GLYCEROL, Myo-inositol-1-phosphate synthase (Ino1), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Neelon, K, Roberts, M.F, Stec, B. | 登録日 | 2011-02-26 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of a trapped catalytic intermediate suggests that forced atomic proximity drives the catalysis of mIPS. Biophys.J., 101, 2011
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