8WD4
 
 | | EGFR(L858R/T790/C797S) in complex with compound 5j | | 分子名称: | CHLORIDE ION, Epidermal growth factor receptor, ~{N}-[3,3-bis(fluoranyl)propyl]-4-[[(2~{S})-butan-2-yl]amino]-6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]pyridine-3-carboxamide | | 著者 | Nishikawa, Y. | | 登録日 | 2023-09-14 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation.
Bioorg.Med.Chem.Lett., 98, 2023
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3WUQ
 | | Structure of the entire stalk region of the dynein motor domain | | 分子名称: | Cytoplasmic dynein 1 heavy chain 1 | | 著者 | Nishikawa, Y, Oyama, T, Kamiya, N, Kon, T, Toyoshima, Y.Y, Nakamura, H, Kurisu, G. | | 登録日 | 2014-05-01 | | 公開日 | 2014-08-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structure of the entire stalk region of the Dynein motor domain
J.Mol.Biol., 426, 2014
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3J6P
 | | Pseudo-atomic model of dynein microtubule binding domain-tubulin complex based on a cryoEM map | | 分子名称: | Dynein heavy chain, cytoplasmic, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Uchimura, S, Fujii, T, Takazaki, H, Ayukawa, R, Nishikawa, Y, Minoura, I, Hachikubo, Y, Kurisu, G, Sutoh, K, Kon, T, Namba, K, Muto, E. | | 登録日 | 2014-03-20 | | 公開日 | 2014-12-31 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | | 主引用文献 | A flipped ion pair at the dynein-microtubule interface is critical for dynein motility and ATPase activation
J.Cell Biol., 208, 2015
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5H47
 | | Crystal structure of AOL complexed with 2-MeSe-Fuc | | 分子名称: | Uncharacterized protein, methyl 6-deoxy-2-Se-methyl-2-seleno-alpha-L-galactopyranoside | | 著者 | Kato, R, Nishikawa, Y, Makyio, H. | | 登録日 | 2016-10-31 | | 公開日 | 2017-01-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Synthesis of seleno-fucose compounds and their application to the X-ray structural determination of carbohydrate-lectin complexes using single/multi-wavelength anomalous dispersion phasing
Bioorg. Med. Chem., 25, 2017
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5AYH
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5WSF
 | | Crystal structure of a cupin protein (tm1459) in osmium (Os)-substituted form II | | 分子名称: | OSMIUM ION, Uncharacterized protein tm1459 | | 著者 | Fujieda, N, Nakano, T, Taniguchi, Y, Ichihashi, H, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2016-12-06 | | 公開日 | 2017-05-31 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.11 Å) | | 主引用文献 | A Well-Defined Osmium-Cupin Complex: Hyperstable Artificial Osmium Peroxygenase
J. Am. Chem. Soc., 2017
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5WSD
 | | Crystal structure of a cupin protein (tm1459) in apo form | | 分子名称: | Uncharacterized protein tm1459 | | 著者 | Fujieda, N, Nakano, T, Taniguchi, Y, Ichihashi, H, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2016-12-06 | | 公開日 | 2017-05-31 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | A Well-Defined Osmium-Cupin Complex: Hyperstable Artificial Osmium Peroxygenase
J. Am. Chem. Soc., 2017
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5WSE
 | | Crystal structure of a cupin protein (tm1459) in osmium (Os) substituted form I | | 分子名称: | OSMIUM ION, Uncharacterized protein tm1459 | | 著者 | Fujieda, N, Nakano, T, Taniguchi, Y, Ichihashi, H, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2016-12-06 | | 公開日 | 2017-05-31 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | | 主引用文献 | A Well-Defined Osmium-Cupin Complex: Hyperstable Artificial Osmium Peroxygenase
J. Am. Chem. Soc., 2017
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6JUD
 | | Radiation damage in Aspergillus oryzae pro-tyrosinase oxygen-bound C92A/H103F mutant | | 分子名称: | COPPER (II) ION, PEROXIDE ION, Tyrosinase | | 著者 | Fujieda, N, Umakoshi, K, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-04-13 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Copper-Oxygen Dynamics in the Tyrosinase Mechanism.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6JU6
 | | Aspergillus oryzae active-tyrosinase copper-depleted C92A mutant | | 分子名称: | NITRATE ION, Tyrosinase | | 著者 | Fujieda, N, Umakoshi, K, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-04-13 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Copper-Oxygen Dynamics in the Tyrosinase Mechanism.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6JUC
 | | Aspergillus oryzae pro-tyrosinase oxygen-bound C92A/H103F mutant | | 分子名称: | COPPER (II) ION, PEROXIDE ION, Tyrosinase | | 著者 | Fujieda, N, Umakoshi, K, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-04-13 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Copper-Oxygen Dynamics in the Tyrosinase Mechanism.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6JU5
 | | Aspergillus oryzae pro-tyrosinase C92A/F513Y mutant | | 分子名称: | COPPER (II) ION, Tyrosinase | | 著者 | Fujieda, N, Umakoshi, K, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-04-13 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Copper-Oxygen Dynamics in the Tyrosinase Mechanism.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6JU8
 | | Aspergillus oryzae active-tyrosinase copper-bound C92A mutant | | 分子名称: | COPPER (II) ION, NITRATE ION, Tyrosinase | | 著者 | Fujieda, N, Umakoshi, K, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-04-13 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | | 主引用文献 | Copper-Oxygen Dynamics in the Tyrosinase Mechanism.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6JUB
 | | Radiation damage in Aspergillus oryzae pro-tyrosinase oxygen-bound C92A mutant | | 分子名称: | COPPER (II) ION, PEROXIDE ION, Tyrosinase | | 著者 | Fujieda, N, Umakoshi, K, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-04-13 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Copper-Oxygen Dynamics in the Tyrosinase Mechanism.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6JU9
 | | Aspergillus oryzae active-tyrosinase copper-bound C92A mutant complexed with L-tyrosine | | 分子名称: | 3,4-DIHYDROXYPHENYLALANINE, COPPER (II) ION, NITRATE ION, ... | | 著者 | Fujieda, N, Umakoshi, K, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-04-13 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Copper-Oxygen Dynamics in the Tyrosinase Mechanism.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6JU7
 | | Aspergillus oryzae active-tyrosinase copper-depleted C92A mutant complexed with L-tyrosine | | 分子名称: | NITRATE ION, TYROSINE, Tyrosinase | | 著者 | Fujieda, N, Umakoshi, K, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-04-13 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Copper-Oxygen Dynamics in the Tyrosinase Mechanism.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6JUA
 | | Aspergillus oryzae pro-tyrosinase oxygen-bound C92A mutant | | 分子名称: | COPPER (II) ION, PEROXIDE ION, Tyrosinase | | 著者 | Fujieda, N, Umakoshi, K, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-04-13 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Copper-Oxygen Dynamics in the Tyrosinase Mechanism.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6JU4
 | | Aspergillus oryzae pro-tyrosinase F513Y mutant | | 分子名称: | COPPER (II) ION, Tyrosinase | | 著者 | Fujieda, N, Umakoshi, K, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-04-13 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Copper-Oxygen Dynamics in the Tyrosinase Mechanism.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6L4P
 | | Crystal structure of the complex between the axonemal outer-arm dynein light chain-1 and microtubule binding domain of gamma heavy chain | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dynein light chain 1, axonemal, ... | | 著者 | Toda, A, Nishikawa, Y, Tanaka, H, Yagi, T, Kurisu, G. | | 登録日 | 2019-10-19 | | 公開日 | 2020-02-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.703 Å) | | 主引用文献 | The complex of outer-arm dynein light chain-1 and the microtubule-binding domain of the gamma heavy chain shows how axonemal dynein tunes ciliary beating.
J.Biol.Chem., 295, 2020
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6L2F
 | | Crystal structure of a cupin protein (tm1459, H54AH58A mutant) in copper (Cu) substituted form | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, COPPER (II) ION, ... | | 著者 | Fujieda, N, Ichihashi, H, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-10-03 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | | 主引用文献 | Cupin Variants as a Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6L2D
 | | Crystal structure of a cupin protein (tm1459) in copper (Cu) substituted form | | 分子名称: | COPPER (II) ION, Cupin_2 domain-containing protein | | 著者 | Fujieda, N, Ichihashi, H, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-10-03 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.198 Å) | | 主引用文献 | Cupin Variants as a Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6L2E
 | | Crystal structure of a cupin protein (tm1459, H52A mutant) in copper (Cu) substituted form | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, COPPER (II) ION, Cupin_2 domain-containing protein | | 著者 | Fujieda, N, Ichihashi, H, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-10-03 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.201 Å) | | 主引用文献 | Cupin Variants as a Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes.
Angew.Chem.Int.Ed.Engl., 59, 2020
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5YXM
 | | Crystal structure of Chlamydomonas Outer Arm Dynein Light Chain 1 | | 分子名称: | Dynein light chain 1, axonemal, PHOSPHATE ION | | 著者 | Toda, A, Tanaka, H, Nishikawa, Y, Yagi, T, Kurisu, G. | | 登録日 | 2017-12-06 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.545 Å) | | 主引用文献 | Structural atlas of dynein motors at atomic resolution.
Biophys Rev, 10, 2018
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