1KS0
 
 | | The First Fibronectin Type II Module from Human Matrix Metalloproteinase 2 | | Descriptor: | Matrix Metalloproteinase 2 | | Authors: | Gehrmann, M, Briknarova, K, Banyai, L, Patthy, L, Llinas, M. | | Deposit date: | 2002-01-10 | | Release date: | 2002-02-20 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | The col-1 module of human matrix metalloproteinase-2 (MMP-2): structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains.
Biol.Chem., 383, 2002
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5APX
 | | Sequence MATKDDIAN inserted between GCN4 adaptors - Structure T9(6) | | Descriptor: | GENERAL CONTROL PROTEIN GCN4, PHOSPHATE ION | | Authors: | Hartmann, M.D, Mendler, C.T, Lupas, A.N, Hernandez Alvarez, B. | | Deposit date: | 2015-09-17 | | Release date: | 2016-01-27 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | alpha / beta coiled coils.
Elife, 5, 2016
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5APS
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5APU
 | | Sequence IANKEDKAD inserted between GCN4 adaptors - Structure A9b black | | Descriptor: | GENERAL CONTROL PROTEIN GCN4, UREA | | Authors: | Hartmann, M.D, Mendler, C.T, Lupas, A.N, Hernandez Alvarez, B. | | Deposit date: | 2015-09-17 | | Release date: | 2016-01-27 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | alpha / beta coiled coils.
Elife, 5, 2016
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5APY
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5MTX
 | | Dibenzooxepinone inhibitor 12b in complex with p38 MAPK | | Descriptor: | 3-[(3-benzamido-4-fluoranyl-phenyl)amino]-~{N}-(2-morpholin-4-ylethyl)-11-oxidanylidene-6~{H}-benzo[c][1]benzoxepine-9-carboxamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | | Authors: | Buehrmann, M, Rauh, D. | | Deposit date: | 2017-01-11 | | Release date: | 2017-09-06 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Design, Synthesis, and Biological Evaluation of Novel Type I(1)/2 p38 alpha MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine.
J. Med. Chem., 60, 2017
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5N6P
 | | AMPA receptor NTD mutant | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2 | | Authors: | Rossmann, M, Krieger, J.M. | | Deposit date: | 2017-02-15 | | Release date: | 2018-03-07 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Allosteric communication pathways in glutamate receptor N-terminal domains
To Be Published
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5MTY
 | | Dibenzosuberone inhibitor 8e in complex with p38 MAPK | | Descriptor: | Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, ~{N}-[2,4-bis(fluoranyl)-5-[[14-(2-hydroxyethylcarbamoyl)-2-oxidanylidene-6-tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaenyl]amino]phenyl]thiophene-2-carboxamide | | Authors: | Buehrmann, M, Rauh, D. | | Deposit date: | 2017-01-11 | | Release date: | 2017-09-06 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Design, Synthesis, and Biological Evaluation of Novel Type I(1)/2 p38 alpha MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine.
J. Med. Chem., 60, 2017
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6ODF
 | | EEEV glycoproteins bound with heparan sulfate | | Descriptor: | 2-O-sulfo-beta-L-galactopyranuronic acid-(1-4)-[(2R,3R,4R,5R,6R)-2,4,5-trihydroxy-6-(sulfooxy)tetrahydro-2H-pyran-3-yl]sulfamic acid, E1, E2 | | Authors: | Rossmann, M.G, Chen, C.L. | | Deposit date: | 2019-03-26 | | Release date: | 2020-04-01 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | Cryo-EM structure of eastern equine encephalitis virus in complex with heparan sulfate analogues.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5APZ
 | | Thermosinus carboxydivorans Nor1 Tcar0761 residues 68-101 and 191-211 fused to GCN4 adaptors | | Descriptor: | GENERAL CONTROL PROTEIN GCN4, NOR1 TCAR0761 | | Authors: | Hartmann, M.D, Deiss, S, Lupas, A.N, Hernandez Alvarez, B. | | Deposit date: | 2015-09-17 | | Release date: | 2016-01-27 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | alpha / beta coiled coils.
Elife, 5, 2016
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5APP
 | | Actinobacillus actinomycetemcomitans OMP100 residues 133-198 fused to GCN4 adaptors | | Descriptor: | CHLORIDE ION, General control protein GCN4,GENERAL CONTROL PROTEIN GCN4, OUTER MEMBRANE PROTEIN 100,General control protein GCN4 | | Authors: | Hartmann, M.D, Ridderbusch, O, Lupas, A.N, Hernandez Alvarez, B. | | Deposit date: | 2015-09-17 | | Release date: | 2016-01-27 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | alpha / beta coiled coils.
Elife, 5, 2016
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5APT
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1HYP
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5APQ
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5ML5
 | | Human p38alpha MAPK in complex with imidazolyl pyridine inhibitor 11b | | Descriptor: | 3-(2,5-dimethoxyphenyl)-~{N}-[4-[4-(4-fluorophenyl)-2-methylsulfanyl-1~{H}-imidazol-5-yl]pyridin-2-yl]propanamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | | Authors: | Buehrmann, M, Rauh, D. | | Deposit date: | 2016-12-06 | | Release date: | 2017-04-05 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1 delta and Their Structural Relation to p38 alpha MAPK.
Molecules, 22, 2017
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3HQ7
 | | CcpA from G. sulfurreducens, G94K/K97Q/R100I variant | | Descriptor: | CALCIUM ION, Cytochrome c551 peroxidase, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Hoffmann, M, Seidel, J, Einsle, O. | | Deposit date: | 2009-06-05 | | Release date: | 2009-09-22 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | CcpA from Geobacter sulfurreducens is a basic di-heme cytochrome c peroxidase.
J.Mol.Biol., 393, 2009
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3HQ8
 | | CcpA from G. sulfurreducens S134P/V135K variant | | Descriptor: | CALCIUM ION, Cytochrome c551 peroxidase, IMIDAZOLE, ... | | Authors: | Hoffmann, M, Seidel, J, Einsle, O. | | Deposit date: | 2009-06-05 | | Release date: | 2009-09-22 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | CcpA from Geobacter sulfurreducens is a basic di-heme cytochrome c peroxidase.
J.Mol.Biol., 393, 2009
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2WPQ
 | | Salmonella enterica SadA 479-519 fused to GCN4 adaptors (SadAK3, in- register fusion) | | Descriptor: | CHLORIDE ION, NITRATE ION, TRIMERIC AUTOTRANSPORTER ADHESIN FRAGMENT | | Authors: | Hartmann, M.D, Hernandez Alvarez, B, Albrecht, R, Zeth, K, Lupas, A.N. | | Deposit date: | 2009-08-09 | | Release date: | 2009-11-03 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | A Coiled-Coil Motif that Sequesters Ions to the Hydrophobic Core.
Proc.Natl.Acad.Sci.USA, 106, 2009
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2B7X
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5LOS
 | | Piriformospora indica PIIN_05872 | | Descriptor: | PIIN_05872, SULFATE ION, ZINC ION | | Authors: | Hartmann, M.D, Albrecht, R, Martin, J, Lupas, A.N. | | Deposit date: | 2016-08-09 | | Release date: | 2018-05-02 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A secreted fungal histidine- and alanine-rich protein regulates metal ion homeostasis and oxidative stress.
New Phytol., 227, 2020
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2WQ2
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6NN3
 | | Structure of parvovirus B19 decorated with Fab molecules from a human antibody | | Descriptor: | Fab monoclonal antibody 860-55D, heavy chain, light chain, ... | | Authors: | Rossmann, M.G, Sun, Y, Klose, T, Liu, Y. | | Deposit date: | 2019-01-14 | | Release date: | 2019-02-13 | | Last modified: | 2020-03-04 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Structure of Parvovirus B19 Decorated by Fabs from a Human Antibody.
J. Virol., 93, 2019
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3GFH
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7OVM
 | | Protein kinase MKK7 in complex with cyclobutyl-substituted indazole | | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 7, ~{N}-[(1-cyclobutyl-1,2,3-triazol-4-yl)methyl]-3-(1~{H}-indazol-3-yl)-5-(propanoylamino)benzamide | | Authors: | Buehrmann, M, Wiese, J.N, Mueller, M.P, Rauh, D. | | Deposit date: | 2021-06-15 | | Release date: | 2022-07-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.
J.Med.Chem., 65, 2022
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7OVN
 | | Protein kinase MKK7 in complex with tolyl-substituted indazole | | Descriptor: | 3-(1~{H}-indazol-3-yl)-~{N}-[[1-(2-methylphenyl)-1,2,3-triazol-4-yl]methyl]-5-(propanoylamino)benzamide, Dual specificity mitogen-activated protein kinase kinase 7 | | Authors: | Buehrmann, M, Wiese, J.N, Mueller, M.P, Rauh, D. | | Deposit date: | 2021-06-15 | | Release date: | 2022-07-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.
J.Med.Chem., 65, 2022
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