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PDB: 2 results

9DLW
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BU of 9dlw by Molmil
Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-41114
Descriptor: DDB1- and CUL4-associated factor 1, N-{(1P)-5'-({(32E)-33-[(3P)-4-{[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]carbamoyl}-3-(4-chloro-2-fluorophenyl)-1H-pyrrol-2-yl]-31-oxo-3,6,9,12,15,18,21,24,27-nonaoxa-30-azatritriacont-32-en-1-yl}carbamoyl)-2'-fluoro-4-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, WD repeat-containing protein 5
Authors:Mabanglo, M.F, Mamai, A, Wilson, B.J, Hoffer, L, Al-awar, R, Vedadi, M.
Deposit date:2024-09-11
Release date:2024-11-06
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Crystal structures of DCAF1-PROTAC-WDR5 complexes provide insight into DCAF1 substrate specificity
To Be Published
9B9W
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BU of 9b9w by Molmil
Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-40792
Descriptor: (4P)-N-[(1R)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-5-[(25E)-1-{(1P)-6-fluoro-3'-[4-fluoro-2-(trifluoromethyl)benzamido]-4'-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-1,24-dioxo-5,8,11,14,17,20-hexaoxa-2,23-diazahexacos-25-en-26-yl]-1H-pyrrole-3-carboxamide, DDB1- and CUL4-associated factor 1, WD repeat-containing protein 5
Authors:Mabanglo, M.F, Wilson, B.J, Mamai, A, Hoffer, L, Al-awar, R, Vedadi, M.
Deposit date:2024-04-03
Release date:2024-11-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structures of DCAF1-PROTAC-WDR5 complexes provide insight into DCAF1 substrate specificity
To Be Published

227561

數據於2024-11-20公開中

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