9J9D
 
 | | Crystal structure of ALK5 kinase domain in complex with inhibitor HM-279 | | Descriptor: | 1,2-ETHANEDIOL, 2-((1-(but-2-yn-1-yl)-1H-pyrazol-4-yl)(cyclopropylmethyl)amino)-5-(4-(dimethylcarbamoyl)-1H-pyrrol-2-yl)thiazole-4-carboxamide, TGF-beta receptor type-1 | | Authors: | Arai, M, Hanada, M, Taniguchi, H, Ohmoto, H, Naka, K, Sawa, M. | | Deposit date: | 2024-08-22 | | Release date: | 2025-04-02 | | Last modified: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (1.337 Å) | | Cite: | Discovery of HM-279, a Potent Inhibitor of ALK5 for Improving Therapeutic Efficacy of Cancer Immunotherapy.
J.Med.Chem., 68, 2025
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